Anti-inflammatory action of insulin via induction of Gadd45-β transcription by the mTOR signaling pathway

por Bortoff, Katherine D, Keeton, Adam B, Franklin, J Lee, Messina, Joseph L
Publicado 2010

The path to the clinic: a comprehensive review on direct KRAS(G12C) inhibitors

por Kwan, Albert K., Piazza, Gary A., Keeton, Adam B., Leite, Caio A.
Publicado 2022

Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers

por Mattox, Tyler E., Chen, Xi, Maxuitenko, Yulia Y., Keeton, Adam B., Piazza, Gary A.
Publicado 2019

Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins

por Almutairi, Maha S, Hassan, Eman S, Keeton, Adam B, Piazza, Gary A, Abdelhameed, Ali S, Attia, Mohamed I
Publicado 2019

β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG

por Lee, Kevin, Lindsey, Ashley S., Li, Nan, Gary, Bernard, Andrews, Joel, Keeton, Adam B., Piazza, Gary A.
Publicado 2015

New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity

por Al-Wabli, Reem I, Almomen, Aliyah A, Almutairi, Maha S, Keeton, Adam B, Piazza, Gary A, Attia, Mohamed I
Publicado 2020

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

por Attia, Mohamed I., Eldehna, Wagdy M., Afifi, Samar A., Keeton, Adam B., Piazza, Gary A., Abdel-Aziz, Hatem A.
Publicado 2017

Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion

por Whitt, Jason D., Keeton, Adam B., Gary, Bernard D., Sklar, Larry A., Sodani, Kamlesh, Chen, Zhe-Sheng, Piazza, Gary A.
Publicado 2016

Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents

por Eldehna, Wagdy M., Al-Wabli, Reem I., Almutairi, Maha S., Keeton, Adam B., Piazza, Gary A., Abdel-Aziz, Hatem A., Attia, Mohamed I.
Publicado 2018

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

por Abdel-Aziz, Hatem A, Eldehna, Wagdy M, Keeton, Adam B, Piazza, Gary A, Kadi, Adnan A, Attwa, Mohamed W, Abdelhameed, Ali S, Attia, Mohamed I
Publicado 2017

NSAIDs: Old Drugs Reveal New Anticancer Targets

por Piazza, Gary A., Keeton, Adam B., Tinsley, Heather N., Whitt, Jason D., Gary, Bernard D., Mathew, Bini, Singh, Raj, Grizzle, William E., Reynolds, Robert C.
Publicado 2010

Enhancing anticancer activity of checkpoint immunotherapy by targeting RAS

por Ward, Antonio B., Keeton, Adam B., Chen, Xi, Mattox, Tyler E., Coley, Alex B., Maxuitenko, Yulia Y., Buchsbaum, Donald J., Randall, Troy D., Zhou, Gang, Piazza, Gary A.
Publicado 2020

Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

por Emmanouilidi, Aikaterini, Casari, Ilaria, Gokcen Akkaya, Begum, Maffucci, Tania, Furic, Luc, Guffanti, Federica, Broggini, Massimo, Chen, Xi, Maxuitenko, Yulia Y., Keeton, Adam B., Piazza, Gary A., Linton, Kenneth J., Falasca, Marco
Publicado 2020

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

por Li, Nan, Chen, Xi, Zhu, Bing, Ramírez-Alcántara, Verónica, Canzoneri, Joshua C., Lee, Kevin, Sigler, Sara, Gary, Bernard, Li, Yonghe, Zhang, Wei, Moyer, Mary P., Salter, E. Alan, Wierzbicki, Andrzej, Keeton, Adam B., Piazza, Gary A.
Publicado 2015

Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer

por Adamska, Aleksandra, Domenichini, Alice, Capone, Emily, Damiani, Verena, Akkaya, Begum Gokcen, Linton, Kenneth J., Di Sebastiano, Pierluigi, Chen, Xi, Keeton, Adam B., Ramirez-Alcantara, Veronica, Maxuitenko, Yulia, Piazza, Gary A., De Laurenzi, Vincenzo, Sala, Gianluca, Falasca, Marco
Publicado 2019

Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats

por Tinsley, Heather N., Mathew, Bini, Chen, Xi, Maxuitenko, Yulia Y., Li, Nan, Lowe, Whitney M., Whitt, Jason D., Zhang, Wei, Gary, Bernard D., Keeton, Adam B., Grizzle, William E., Grubbs, Clinton J., Reynolds, Robert C., Piazza, Gary A.
Publicado 2023

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule The...

por Chung, W. Joon, Goeckeler-Fried, Jennifer L., Havasi, Viktoria, Chiang, Annette, Rowe, Steven M., Plyler, Zackery E., Hong, Jeong S., Mazur, Marina, Piazza, Gary A., Keeton, Adam B., White, E. Lucile, Rasmussen, Lynn, Weissman, Allan M., Denny, R. Aldrin, Brodsky, Jeffrey L., Sorscher, Eric J.
Publicado 2016

Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling

por Zhu, Bing, Lindsey, Ashley, Li, Nan, Lee, Kevin, Ramirez-Alcantara, Veronica, Canzoneri, Joshua C., Fajardo, Alexandra, Madeira da Silva, Luciana, Thomas, Meagan, Piazza, John T., Yet, Larry, Eberhardt, Brian T., Gurpinar, Evrim, Otali, Dennis, Grizzle, William, Valiyaveettil, Jacob, Chen, Xi, Keeton, Adam B., Piazza, Gary A.
Publicado 2017

Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

por Borneman, Rebecca M., Gavin, Elaine, Musiyenko, Alla, Richter, Wito, Lee, Kevin J., Crossman, David K., Andrews, Joel F., Wilhite, Annelise M., McClellan, Steven, Aragon, Ileana, Ward, Antonio B., Chen, Xi, Keeton, Adam B., Berry, Kristy, Piazza, Gary A., Scalici, Jennifer M., da Silva, Luciana Madeira
Publicado 2022

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity

por Li, Nan, Lee, Kevin, Xi, Yaguang, Zhu, Bing, Gary, Bernard D., Ramírez-Alcántara, Verónica, Gurpinar, Evrim, Canzoneri, Joshua C., Fajardo, Alexandra, Sigler, Sara, Piazza, John T., Chen, Xi, Andrews, Joel, Thomas, Meagan, Lu, Wenyan, Li, Yonghe, Laan, Danuel J., Moyer, Mary P., Russo, Suzanne, Eberhardt, Brian T., Yet, Larry, Keeton, Adam B., Grizzle, William E., Piazza, Gary A.
Publicado 2014