Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining

por Kefala Stavridi, Antonia, Appleby, Robert, Liang, Shikang, Blundell, Tom L., Chaplin, Amanda K.
Publicado 2020

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

por Chaplin, Amanda K., Hardwick, Steven W., Kefala Stavridi, Antonia, Buehl, Christopher J., Goff, Noah J., Ropars, Virginie, Liang, Shikang, De Oliveira, Taiana Maia, Chirgadze, Dimitri Y., Meek, Katheryn, Charbonnier, Jean-Baptiste, Blundell, Tom L.
Publicado 2021

PAXX binding to the NHEJ machinery explains functional redundancy with XLF

por Seif-El-Dahan, Murielle, Kefala-Stavridi, Antonia, Frit, Philippe, Hardwick, Steven W., Chirgadze, Dima Y., Maia De Oliviera, Taiana, Britton, Sébastien, Barboule, Nadia, Bossaert, Madeleine, Pandurangan, Arun Prasad, Meek, Katheryn, Blundell, Tom L., Ropars, Virginie, Calsou, Patrick, Charbonnier, Jean-Baptiste, Chaplin, Amanda K.
Publicado 2023

Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction

por Kefala Stavridi, Antonia, Gontier, Amandine, Morin, Vincent, Frit, Philippe, Ropars, Virginie, Barboule, Nadia, Racca, Carine, Jonchhe, Sagun, Morten, Michael J, Andreani, Jessica, Rak, Alexey, Legrand, Pierre, Bourand-Plantefol, Alexa, Hardwick, Steven W, Chirgadze, Dimitri Y, Davey, Paul, De Oliveira, Taiana Maia, Rothenberg, Eli, Britton, Sebastien, Calsou, Patrick, Blundell, Tom L, Varela, Paloma F, Chaplin, Amanda K, Charbonnier, Jean-Baptiste
Publicado 2023