Dynamic treatment effect (DTE) curves reveal the mode of action for standard and experimental cancer therapies

por Choudhury, Kingshuk Roy, Keir, Stephen T., Ashcraft, Kathleen A., Boss, Mary-Keara, Dewhirst, Mark W.
Publicado 2015

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors

por Yu, Xin, Dobrikov, Mikhail, Keir, Stephen T., Gromeier, Matthias, Pastan, Ira H., Reisfeld, Ralph, Bigner, Darell D., Chandramohan, Vidyalakshmi
Publicado 2019

Antitumor efficacy of D2C7-(scdsFv)-PE38KDEL, a novel immunotoxin targeting EGFRwt and EGFRvIII, by convection-enhanced delivery in orthotopic brain tumor mouse models

por Bao, Xuhui, Chandramohan, Vidyalakshmi, Keir, Stephen T, Pegram, Charles N, McLendon, Roger E, Kuan, Chien-Tsun, Pastan, Ira H, Bigner, Darell D
Publicado 2013

Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models

por Keir, Stephen T., Chandramohan, Vidyalakshmi, Hemphill, Carlee D., Grandal, Michael M., Melander, Maria Carlsen, Pedersen, Mikkel W., Horak, Ivan D., Kragh, Michael, Desjardins, Annick, Friedman, Henry S., Bigner, Darell D.
Publicado 2018

BSCI-20 STING EPIGENETIC SILENCING IN GLIOMAS CAN BE RESCUED BY METHYLTRANSFERASE INHIBITION: IMPLICATIONS FOR NOVEL THERAPEUTIC APPROACHES

por Low, Justin, Chandramohan, Vidya, Bowie, Michelle, Brown, Michael, Waitkus, Matthew, Briley, Aaron, Stevenson, Kevin, Fuller, Rebecca, Hostettler, Janell, Reitman, Zachary, Charbonneau, Casey, Keir, Stephen, Khasraw, Mustafa, Ashley, David
Publicado 2022

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation

por Guo, Changcun, Chen, Lee H., Huang, Yafen, Chang, Chun-Chi, Wang, Ping, Pirozzi, Christopher J., Qin, Xiaoxia, Bao, Xuhui, Greer, Paula K., McLendon, Roger E., Yan, Hai, Keir, Stephen T., Bigner, Darell D., He, Yiping
Publicado 2013

Repurposing Clemastine to Target Glioblastoma Cell Stemness

por Sun, Michael A., Yang, Rui, Liu, Heng, Wang, Wenzhe, Song, Xiao, Hu, Bo, Reynolds, Nathan, Roso, Kristen, Chen, Lee H., Greer, Paula K., Keir, Stephen T., McLendon, Roger E., Cheng, Shi-Yuan, Bigner, Darell D., Ashley, David M., Pirozzi, Christopher J., He, Yiping
Publicado 2023

Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer

por Carol, Hernan, Boehm, Ingrid, Reynolds, C. Patrick, Kang, Min H., Maris, John M., Morton, Christopher L., Gorlick, Richard, Kolb, E. Anders, Keir, Stephen T., Wu, Jianrong, Wozniak, Amy E., Yang, Yu, Manfredi, Mark, Ecsedy, Jeffrey, Wang, Jianmin, Neale, Geoffrey, Houghton, Peter J., Smith, Malcolm A., Lock, Richard B.
Publicado 2011

Exomic Sequencing of Four Rare Central Nervous System Tumor Types

por Bettegowda, Chetan, Agrawal, Nishant, Jiao, Yuchen, Wang, Yuxuan, Wood, Laura D., Rodriguez, Fausto J., Hruban, Ralph H., Gallia, Gary L., Binder, Zev A., Riggins, Callen J., Salmasi, Vafi, Riggins, Gregory J., Reitman, Zachary J., Rasheed, Ahmed, Keir, Stephen, Shinjo, Sueli, Marie, Suely, McLendon, Roger, Jallo, George, Vogelstein, Bert, Bigner, Darell, Yan, Hai, Kinzler, Kenneth W., Papadopoulos, Nickolas
Publicado 2013

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

por Killela, Patrick J., Pirozzi, Christopher J., Healy, Patrick, Reitman, Zachary J., Lipp, Eric, Rasheed, B. Ahmed, Yang, Rui, Diplas, Bill H., Wang, Zhaohui, Greer, Paula K., Zhu, Huishan, Wang, Catherine Y., Carpenter, Austin B., Friedman, Henry, Friedman, Allan H., Keir, Stephen T., He, Jie, He, Yiping, McLendon, Roger E., Herndon II, James E., Yan, Hai, Bigner, Darell D.
Publicado 2014

The integrated landscape of driver genomic alterations in glioblastoma

por Frattini, Veronique, Trifonov, Vladimir, Chan, Joseph Minhow, Castano, Angelica, Lia, Marie, Abate, Francesco, Keir, Stephen T., Ji, Alan X., Zoppoli, Pietro, Niola, Francesco, Danussi, Carla, Dolgalev, Igor, Porrati, Paola, Pellegatta, Serena, Heguy, Adriana, Gupta, Gaurav, Pisapia, David J., Canoll, Peter, Bruce, Jeffrey N., McLendon, Roger E., Yan, Hai, Aldape, Ken, Finocchiaro, Gaetano, Mikkelsen, Tom, Privé, Gilbert G., Bigner, Darell D., Lasorella, Anna, Rabadan, Raul, Iavarone, Antonio
Publicado 2013

Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti...

por Marquardt, Viktoria, Theruvath, Johanna, Pauck, David, Picard, Daniel, Qin, Nan, Blümel, Lena, Maue, Mara, Bartl, Jasmin, Ahmadov, Ulvi, Langini, Maike, Meyer, Frauke-Dorothee, Cole, Allison, Cruz-Cruz, Joselyn, Graef, Claus M, Wölfl, Matthias, Milde, Till, Witt, Olaf, Erdreich-Epstein, Anat, Leprivier, Gabriel, Kahlert, Ulf, Stefanski, Anja, Stühler, Kai, Keir, Stephen T, Bigner, Darell D, Hauer, Julia, Beez, Thomas, Knobbe-Thomsen, Christiane B, Fischer, Ute, Felsberg, Jörg, Hansen, Finn K, Vibhakar, Rajeev, Venkatraman, Sujatha, Cheshier, Samuel H, Reifenberger, Guido, Borkhardt, Arndt, Kurz, Thomas, Remke, Marc, Mitra, Siddhartha
Publicado 2023

Therapeutic Targeting of Ependymoma as Informed by Oncogenic Enhancer Profiling

por Mack, Stephen C., Pajtler, Kristian W., Chavez, Lukas, Okonechnikov, Konstantin, Bertrand, Kelsey C., Wang, Xiuxing, Erkek, Serap, Federation, Alexander, Song, Anne, Lee, Christine, Wang, Xin, McDonald, Laura, Morrow, James J., Saiakhova, Alina, Sin-Chan, Patrick, Wu, Qiulian, Michaelraj, Antony, Miller, Tyler E., Hubert, Christopher G., Ryzhova, Marina, Garzia, Livia, Donovan, Laura, Dombrowski, Stephen, Factor, Daniel C., Luu, Betty, Valentim, Claudia L.L., Gimple, Ryan C., Morton, Andrew, Kim, Leo, Prager, Briana C., Lee, John J.Y., Wu, Xiaochong, Zuccaro, Jennifer, Thompson, Yuan, de Borja López Holgado, Francisco, Reimand, Juri, Ke, Susan Q., Tropper, Adam, Lai, Sisi, Vijayarajah, Senthuran, Doan, Sylvia, Mahadev, Vaidehi, Miñan, Ana Fernandez, Gröbner, Susanne N., Lienhard, Matthias, Zapatka, Marc, Huang, Zhiqin, Aldape, Kenneth D., Carcaboso, Angel M., Houghton, Peter J., Keir, Stephen T., Milde, Till, Witt, Hendrik, Li, Yan, Li, Chao-Jun, Bian, Xiu-Wu, Jones, David T.W., Scott, Ian, Singh, Sheila K., Huang, Annie, Dirks, Peter B., Bouffet, Eric, Bradner, James E., Ramaswamy, Vijay, Jabado, Nada, Rutka, James T., Northcott, Paul A., Lupien, Mathieu, Lichter, Peter, Korshunov, Andrey, Scacheri, Peter C., Pfister, Stefan M., Kool, Marcel, Taylor, Michael D., Rich, Jeremy N.
Publicado 2017