Unexpected new insights into DNA clamp loaders: Eukaryotic clamp loaders contain a second DNA site for recessed 5′ ends that facilitates repair and signals DNA damage

por Li, Huilin, O'Donnell, Mike, Kelch, Brian
Publicado 2022

Conformational dynamics control assembly of an extremely long bacteriophage tail tube

por Agnello, Emily, Pajak, Joshua, Liu, Xingchen, Kelch, Brian A.
Publicado 2023

A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA

por Liu, Xingchen, Gaubitz, Christl, Pajak, Joshua, Kelch, Brian A
Publicado 2022

Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure

por Stone, Nicholas P., Demo, Gabriel, Agnello, Emily, Kelch, Brian A.
Publicado 2019

Clamp loader ATPases and the evolution of DNA replication machinery

por Kelch, Brian A, Makino, Debora L, O'Donnell, Mike, Kuriyan, John
Publicado 2012

Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex

por Paul Solomon Devakumar, Lovely Jael, Gaubitz, Christl, Lundblad, Victoria, Kelch, Brian A, Kubota, Takashi
Publicado 2019

The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain

por Hilbert, Brendan J., Hayes, Janelle A., Stone, Nicholas P., Xu, Rui-Gang, Kelch, Brian A.
Publicado 2017

Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

por Gaubitz, Christl, Liu, Xingchen, Pajak, Joshua, Stone, Nicholas P, Hayes, Janelle A, Demo, Gabriel, Kelch, Brian A
Publicado 2022

A structural role for the PHP domain in E. coli DNA polymerase III

por Barros, Tiago, Guenther, Joel, Kelch, Brian, Anaya, Jordan, Prabhakar, Arjun, O’Donnell, Mike, Kuriyan, John, Lamers, Meindert H
Publicado 2013

Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor

por Pajak, Joshua, Dill, Erik, Reyes-Aldrete, Emilio, White, Mark A, Kelch, Brian A, Jardine, Paul J, Arya, Gaurav, Morais, Marc C
Publicado 2021

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

por Silvas, Tania V., Hou, Shurong, Myint, Wazo, Nalivaika, Ellen, Somasundaran, Mohan, Kelch, Brian A., Matsuo, Hiroshi, Kurt Yilmaz, Nese, Schiffer, Celia A.
Publicado 2018

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

por Kouno, Takahide, Silvas, Tania V., Hilbert, Brendan J., Shandilya, Shivender M. D., Bohn, Markus F., Kelch, Brian A., Royer, William E., Somasundaran, Mohan, Kurt Yilmaz, Nese, Matsuo, Hiroshi, Schiffer, Celia A.
Publicado 2017

CaMKII binds both substrates and activators at the active site

por Özden, Can, Sloutsky, Roman, Mitsugi, Tomohiro, Santos, Nicholas, Agnello, Emily, Gaubitz, Christl, Foster, Joshua, Lapinskas, Emily, Esposito, Edward A., Saneyoshi, Takeo, Kelch, Brian A., Garman, Scott C., Hayashi, Yasunori, Stratton, Margaret M.
Publicado 2022

A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder

por Magrino, Joseph, Munford, Veridiana, Martins, Davi Jardim, Homma, Thais K., Page, Brendan, Gaubitz, Christl, Freire, Bruna L., Lerario, Antonio M., Vilar, Juliana Brandstetter, Amorin, Antonio, Leão, Emília K.E., Kok, Fernando, Menck, Carlos FM., Jorge, Alexander AL., Kelch, Brian A.
Publicado 2023