Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood–brain barrier permeability

por Borsari, Chiara, Keles, Erhan, Treyer, Andrea, De Pascale, Martina, Hebeisen, Paul, Hamburger, Matthias, Wymann, Matthias P.
Publicado 2021

Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl–Pyrimidine Moiety

por Borsari, Chiara, Rageot, Denise, Beaufils, Florent, Bohnacker, Thomas, Keles, Erhan, Buslov, Ivan, Melone, Anna, Sele, Alexander M., Hebeisen, Paul, Fabbro, Doriano, Hillmann, Petra, Wymann, Matthias P.
Publicado 2019

Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα

por Borsari, Chiara, Keles, Erhan, McPhail, Jacob A., Schaefer, Alexander, Sriramaratnam, Rohitha, Goch, Wojciech, Schaefer, Thorsten, De Pascale, Martina, Bal, Wojciech, Gstaiger, Matthias, Burke, John E., Wymann, Matthias P.
Publicado 2022