Challenges and opportunities identifying therapeutic targets for chemotherapy-induced peripheral neuropathy resulting from oxidative DNA damage

por Kelley, Mark R., Fehrenbacher, Jill C.
Publicado 2017

Oxidative DNA Damage: A Role in Altering Neuronal Function

por Behrouzi, Adib, Kelley, Mark R., Fehrenbacher, Jill C.
Publicado 2022

Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy

por Hartman, Gabriella D., Lambert-Cheatham, Nathan A., Kelley, Mark R., Corson, Timothy W.
Publicado 2021

Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons

por Behrouzi, Adib, Xia, Hanyu, Thompson, Eric L., Kelley, Mark R., Fehrenbacher, Jill C.
Publicado 2022

APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease

por Sahakian, Lauren, Robinson, Ainsley M., Sahakian, Linda, Stavely, Rhian, Kelley, Mark R., Nurgali, Kulmira
Publicado 2023

Role of the DNA Base Excision Repair Protein, APE1 in Cisplatin, Oxaliplatin, or Carboplatin Induced Sensory Neuropathy

por Kelley, Mark R., Jiang, Yanlin, Guo, Chunlu, Reed, April, Meng, Hongdi, Vasko, Michael R.
Publicado 2014

Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase

por Kremer, Ted M, Rinne, Mikael L, Xu, Yi, Chen, Xian Ming, Kelley, Mark R
Publicado 2004

APE1/Ref-1 – One Target with Multiple Indications: Emerging Aspects and New Directions

por Mijit, Mahmut, Caston, Rachel, Gampala, Silpa, Fishel, Melissa L., Fehrenbacher, Jill, Kelley, Mark R.
Publicado 2021

Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease

por Muniyandi, Anbukkarasi, Hartman, Gabriella D., Song, Yang, Mijit, Mahmut, Kelley, Mark R., Corson, Timothy W.
Publicado 2023

Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-Α-Induced Activation of Il-8 Production in Liver Cancer Cell Lines

por Cesaratto, Laura, Codarin, Erika, Vascotto, Carlo, Leonardi, Antonio, Kelley, Mark R., Tiribelli, Claudio, Tell, Gianluca
Publicado 2013

Correction: Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-Α-Induced Activation of Il-8 Production in Liver Cancer Cell Lines

por Cesaratto, Laura, Codarin, Erika, Vascotto, Carlo, Leonardi, Antonio, Kelley, Mark R., Tiribelli, Claudio, Tell, Gianluca
Publicado 2013

APE1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell RNA sequencing

por Shah, Fenil, Goossens, Emery, Atallah, Nadia M., Grimard, Michelle, Kelley, Mark R., Fishel, Melissa L.
Publicado 2017

APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells

por McIlwain, David W., Fishel, Melissa L., Boos, Alexander, Kelley, Mark R., Jerde, Travis J.
Publicado 2017

Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic

por Shah, Fenil, Logsdon, Derek, Messmann, Richard A., Fehrenbacher, Jill C., Fishel, Melissa L., Kelley, Mark R.
Publicado 2017

APE1/Ref-1 as a Novel Target for Retinal Diseases

por Heisel, Curtis, Yousif, Jonah, Mijiti, Mahmut, Charizanis, Kostas, Brigell, Mitchel, Corson, Timothy W., Kelley, Mark R.
Publicado 2021

Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells

por Mijit, Mahmut, Liu, Sheng, Sishtla, Kamakshi, Hartman, Gabriella D., Wan, Jun, Corson, Timothy W., Kelley, Mark R.
Publicado 2023

Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP

por Pines, Alex, Perrone, Lorena, Bivi, Nicoletta, Romanello, Milena, Damante, Giuseppe, Gulisano, Massimo, Kelley, Mark R., Quadrifoglio, Franco, Tell, Gianluca
Publicado 2005

APX3330 Promotes Neurorestorative Effects after Stroke in Type One Diabetic Rats

por Yan, Tao, Venkat, Poornima, Chopp, Michael, Zacharek, Alex, Yu, Peng, Ning, Ruizhuo, Qiao, Xiaoxi, Kelley, Mark R., Chen, Jieli
Publicado 2018

APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival

por Cardoso, Angelo A., Jiang, Yanlin, Luo, Meihua, Reed, April M., Shahda, Safi, He, Ying, Maitra, Anirban, Kelley, Mark R., Fishel, Melissa L.
Publicado 2012

RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cell...

por Mijit, Mahmut, Wireman, Randall, Armstrong, Lee, Gampala, Silpa, Hassan, Zonera, Schneeweis, Christian, Schneider, Guenter, Zhang, Chi, Fishel, Melissa L., Kelley, Mark R.
Publicado 2022