High Affinity Antigen Recognition of the Dual Specific Variants of Herceptin Is Entropy-Driven in Spite of Structural Plasticity

por Bostrom, Jenny, Haber, Lauric, Koenig, Patrick, Kelley, Robert F., Fuh, Germaine
Publicado 2011

Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics

por Shivva, Vittal, Boswell, C. Andrew, Rafidi, Hanine, Kelley, Robert F., Kamath, Amrita V., Crowell, Susan R.
Publicado 2021

Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity

por Shatz, Whitney, Chung, Shan, Li, Bing, Marshall, Brett, Tejada, Max, Phung, Wilson, Sandoval, Wendy, Kelley, Robert F, Scheer, Justin M
Publicado 2013

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

por Crowell, Susan R., Wang, Kathryn, Famili, Amin, Shatz, Whitney, Loyet, Kelly M., Chang, Vincent, Liu, Yanqiu, Prabhu, Saileta, Kamath, Amrita V., Kelley, Robert F.
Publicado 2019

Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms

por Hecht, Elizabeth Sara, Mehta, Shrenik, Wecksler, Aaron T., Aguilar, Ben, Swanson, Nathaniel, Phung, Wilson, Dubey Kelsoe, Ananya, Benner, W. Henry, Tesar, Devin, Kelley, Robert F., Sandoval, Wendy, Sreedhara, Alavattam
Publicado 2022

Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye

por Shatz, Whitney, Hass, Philip E., Peer, Nikhil, Paluch, Maciej T., Blanchette, Craig, Han, Guanghui, Sandoval, Wendy, Morando, Ashley, Loyet, Kelly M., Bantseev, Vladimir, Booler, Helen, Crowell, Susan, Kamath, Amrita, Scheer, Justin M., Kelley, Robert F.
Publicado 2019

Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye

por Tesar, Devin, Luoma, Jacob, Wyatt, Emily A., Shi, Catherine, Shatz, Whitney, Hass, Philip E., Mathieu, Mary, Yi, Li, Corn, Jacob E., Maass, Katie F., Wang, Kathryn, Dion, Michelle Z., Andersen, Nisana, Loyet, Kelly M., van Lookeren Campagne, Menno, Rajagopal, Karthikan, Dickmann, Leslie, Scheer, Justin M., Kelley, Robert F.
Publicado 2017