The Queuine Micronutrient: Charting a Course from Microbe to Man

por Fergus, Claire, Barnes, Dominic, Alqasem, Mashael A., Kelly, Vincent P.
Publicado 2015

The “speed gene” effect of myostatin arises in Thoroughbred horses due to a promoter proximal SINE insertion

por Rooney, Mary F., Hill, Emmeline W., Kelly, Vincent P., Porter, Richard K.
Publicado 2018

Disruption to tRNA Modification by Queuine Contributes to Inflammatory Bowel Disease

por Zhang, Jilei, Zhang, Yongguo, McGrenaghan, Callum J., Kelly, Vincent P., Xia, Yinglin, Sun, Jun
Publicado 2023

Queuine links translational control in eukaryotes to a micronutrient from bacteria

por Müller, Martin, Legrand, Carine, Tuorto, Francesca, Kelly, Vincent P, Atlasi, Yaser, Lyko, Frank, Ehrenhofer-Murray, Ann E
Publicado 2019

A non-toxic, reversibly released imaging probe for oral cancer that is derived from natural compounds

por Ghanim, Magda, Relitti, Nicola, McManus, Gavin, Butini, Stefania, Cappelli, Andrea, Campiani, Giuseppe, Mok, K. H., Kelly, Vincent P.
Publicado 2021

In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis

por Varghese, Sreeja, Cotter, Michelle, Chevot, Franciane, Fergus, Claire, Cunningham, Colm, Mills, Kingston H., Connon, Stephen J., Southern, John M., Kelly, Vincent P.
Publicado 2017

Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells

por Hayes, Patti, Fergus, Claire, Ghanim, Magda, Cirzi, Cansu, Burtnyak, Lyubomyr, McGrenaghan, Callum J., Tuorto, Francesca, Nolan, Derek P., Kelly, Vincent P.
Publicado 2020

Investigating the Impact of Delivery Routes for Exon Skipping Therapies in the CNS of DMD Mouse Models

por Saoudi, Amel, Fergus, Claire, Gileadi, Talia, Montanaro, Federica, Morgan, Jennifer E., Kelly, Vincent P., Tensorer, Thomas, Garcia, Luis, Vaillend, Cyrille, Muntoni, Francesco, Goyenvalle, Aurélie
Publicado 2023

5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice

por Saitoh, Shinichi, Okano, Satoshi, Nohara, Hidekazu, Nakano, Hiroshi, Shirasawa, Nobuyuki, Naito, Akira, Yamamoto, Masayuki, Kelly, Vincent P., Takahashi, Kiwamu, Tanaka, Tohru, Nakajima, Motowo, Nakajima, Osamu
Publicado 2018

The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity

por Fergus, Claire, Al-qasem, Mashael, Cotter, Michelle, McDonnell, Ciara M, Sorrentino, Emiliano, Chevot, Franciane, Hokamp, Karsten, Senge, Mathias O, Southern, John M, Connon, Stephen J, Kelly, Vincent P
Publicado 2021

Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5′-monophosphate as the biological substrate

por Hung, Shr-Hau, Elliott, Gregory I, Ramkumar, Thakku R, Burtnyak, Lyubomyr, McGrenaghan, Callum J, Alkuzweny, Sana, Quaiyum, Samia, Iwata-Reuyl, Dirk, Pan, Xiaobei, Green, Brian D, Kelly, Vincent P, de Crécy-Lagard, Valérie, Swairjo, Manal A
Publicado 2023

Malonylation of GAPDH is an inflammatory signal in macrophages

por Galván-Peña, Silvia, Carroll, Richard G., Newman, Carla, Hinchy, Elizabeth C., Palsson-McDermott, Eva, Robinson, Elektra K., Covarrubias, Sergio, Nadin, Alan, James, Andrew M., Haneklaus, Moritz, Carpenter, Susan, Kelly, Vincent P., Murphy, Michael P., Modis, Louise K., O’Neill, Luke A.
Publicado 2019