Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5

por Upadhyay, Anup K., Cyr, Matthew, Longenecker, Kenton, Tripathi, Rakesh, Sun, Chaohong, Kempf, Dale J.
Publicado 2017

A mouse infection model and long-term lymphatic endothelium co-culture system to evaluate drugs against adult Brugia malayi

por Marriott, Amy E., Furlong Silva, Julio, Pionnier, Nicolas, Sjoberg, Hanna, Archer, John, Steven, Andrew, Kempf, Dale, Taylor, Mark J., Turner, Joseph D.
Publicado 2022

A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti-Wolbachia and antifilarial activity

por Alami, Negar, Carter, David C., Kwatra, Nisha V., Zhao, Weihan, Snodgrass, Linda, Porcalla, Ariel R., Klein, Cheri E., Cohen, Daniel E., Gallenberg, Loretta, Neenan, Melina, Carr, Robert A., Marsh, Kennan C., Kempf, Dale J.
Publicado 2023

Novel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening

por Kumar, Anuradha, Chettiar, Somsundaram, Brown, Brian S., Early, Julie, Ollinger, Juliane, Files, Megan, Bailey, Mai A., Korkegian, Aaron, Dennison, Devon, McNeil, Matthew, Metz, James, Osuma, Augustine, Curtin, Michael, Kunzer, Aaron, Freiberg, Gail, Bruncko, Milan, Kempf, Dale, Parish, Tanya
Publicado 2022

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

por Hübner, Marc P., Koschel, Marianne, Struever, Dominique, Nikolov, Venelin, Frohberger, Stefan J., Ehrens, Alexandra, Fendler, Martina, Johannes, Iliana, von Geldern, Thomas W., Marsh, Kennan, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., Pfarr, Kenneth, Kempf, Dale J., Hoerauf, Achim
Publicado 2019

ART Suppresses Plasma HIV-1 RNA to a Stable Set Point Predicted by Pretherapy Viremia

por Maldarelli, Frank, Palmer, Sarah, King, Martin S, Wiegand, Ann, Polis, Michael A, Mican, JoAnn, Kovacs, Joseph A, Davey, Richard T, Rock-Kress, Diane, Dewar, Robin, Liu, Shuying, Metcalf, Julia A, Rehm, Catherine, Brun, Scott C, Hanna, George J, Kempf, Dale J, Coffin, John M, Mellors, John W
Publicado 2007

In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir

por Ng, Teresa I., Tripathi, Rakesh, Reisch, Thomas, Lu, Liangjun, Middleton, Timothy, Hopkins, Todd A., Pithawalla, Ron, Irvin, Michelle, Dekhtyar, Tatyana, Krishnan, Preethi, Schnell, Gretja, Beyer, Jill, McDaniel, Keith F., Ma, Jun, Wang, Guoqiang, Jiang, Li-Juan, Or, Yat Sun, Kempf, Dale, Pilot-Matias, Tami, Collins, Christine
Publicado 2017

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

por von Geldern, Thomas W., Morton, Howard E., Clark, Rick F., Brown, Brian S., Johnston, Kelly L., Ford, Louise, Specht, Sabine, Carr, Robert A., Stolarik, Deanne F., Ma, Junli, Rieser, Matthew J., Struever, Dominique, Frohberger, Stefan J., Koschel, Marianne, Ehrens, Alexandra, Turner, Joseph D., Hübner, Marc P., Hoerauf, Achim, Taylor, Mark J., Ward, Stephen A., Marsh, Kennan, Kempf, Dale J.
Publicado 2019

Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis

por Hulverson, Matthew A., Choi, Ryan, Schaefer, Deborah A., Betzer, Dana P., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Lee, Sangun, Pranata, Andy, McLeod, Malcolm D., Marsh, Kennan C., Kempf, Dale J., LeRoy, Bruce E., Zafiratos, Mark T., Bielinski, Aimee L., Hackman, Robert C., Ojo, Kayode K., Arnold, Samuel L. M., Barrett, Lynn K., Tzipori, Saul, Riggs, Michael W., Fan, Erkang, Van Voorhis, Wesley C.
Publicado 2023

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

por Huang, Wenlin, Ojo, Kayode K., Zhang, Zhongsheng, Rivas, Kasey, Vidadala, Rama Subba Rao, Scheele, Suzanne, DeRocher, Amy E., Choi, Ryan, Hulverson, Matthew A., Barrett, Lynn K., Bruzual, Igor, Siddaramaiah, Latha Kallur, Kerchner, Keshia M., Kurnick, Matthew D., Freiberg, Gail M., Kempf, Dale, Hol, Wim G. J., Merritt, Ethan A., Neckermann, Georg, de Hostos, Eugenio L., Isoherranen, Nina, Maly, Dustin J., Parsons, Marilyn, Doggett, J. Stone, Van Voorhis, Wesley C., Fan, Erkang
Publicado 2015

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

por Ray, Peter C., Huggett, Margaret, Turner, Penelope A., Taylor, Malcolm, Cleghorn, Laura A. T., Early, Julie, Kumar, Anuradha, Bonnett, Shilah A., Flint, Lindsay, Joerss, Douglas, Johnson, James, Korkegian, Aaron, Mullen, Steven, Moure, Abraham L., Davis, Susan H., Murugesan, Dinakaran, Mathieson, Michael, Caldwell, Nicola, Engelhart, Curtis A., Schnappinger, Dirk, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Massoudi, Lisa, Robertson, Gregory T., Lenaerts, Anne J., Freiberg, Gail, Kempf, Dale J., Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Read, Kevin D., Green, Simon R., Wyatt, Paul G., Parish, Tanya
Publicado 2021