Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5

por Upadhyay, Anup K., Cyr, Matthew, Longenecker, Kenton, Tripathi, Rakesh, Sun, Chaohong, Kempf, Dale J.
Publicado 2017

A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti-Wolbachia and antifilarial activity

por Alami, Negar, Carter, David C., Kwatra, Nisha V., Zhao, Weihan, Snodgrass, Linda, Porcalla, Ariel R., Klein, Cheri E., Cohen, Daniel E., Gallenberg, Loretta, Neenan, Melina, Carr, Robert A., Marsh, Kennan C., Kempf, Dale J.
Publicado 2023

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

por Hübner, Marc P., Koschel, Marianne, Struever, Dominique, Nikolov, Venelin, Frohberger, Stefan J., Ehrens, Alexandra, Fendler, Martina, Johannes, Iliana, von Geldern, Thomas W., Marsh, Kennan, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., Pfarr, Kenneth, Kempf, Dale J., Hoerauf, Achim
Publicado 2019

ART Suppresses Plasma HIV-1 RNA to a Stable Set Point Predicted by Pretherapy Viremia

por Maldarelli, Frank, Palmer, Sarah, King, Martin S, Wiegand, Ann, Polis, Michael A, Mican, JoAnn, Kovacs, Joseph A, Davey, Richard T, Rock-Kress, Diane, Dewar, Robin, Liu, Shuying, Metcalf, Julia A, Rehm, Catherine, Brun, Scott C, Hanna, George J, Kempf, Dale J, Coffin, John M, Mellors, John W
Publicado 2007

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

por von Geldern, Thomas W., Morton, Howard E., Clark, Rick F., Brown, Brian S., Johnston, Kelly L., Ford, Louise, Specht, Sabine, Carr, Robert A., Stolarik, Deanne F., Ma, Junli, Rieser, Matthew J., Struever, Dominique, Frohberger, Stefan J., Koschel, Marianne, Ehrens, Alexandra, Turner, Joseph D., Hübner, Marc P., Hoerauf, Achim, Taylor, Mark J., Ward, Stephen A., Marsh, Kennan, Kempf, Dale J.
Publicado 2019

Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis

por Hulverson, Matthew A., Choi, Ryan, Schaefer, Deborah A., Betzer, Dana P., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Lee, Sangun, Pranata, Andy, McLeod, Malcolm D., Marsh, Kennan C., Kempf, Dale J., LeRoy, Bruce E., Zafiratos, Mark T., Bielinski, Aimee L., Hackman, Robert C., Ojo, Kayode K., Arnold, Samuel L. M., Barrett, Lynn K., Tzipori, Saul, Riggs, Michael W., Fan, Erkang, Van Voorhis, Wesley C.
Publicado 2023

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

por Ray, Peter C., Huggett, Margaret, Turner, Penelope A., Taylor, Malcolm, Cleghorn, Laura A. T., Early, Julie, Kumar, Anuradha, Bonnett, Shilah A., Flint, Lindsay, Joerss, Douglas, Johnson, James, Korkegian, Aaron, Mullen, Steven, Moure, Abraham L., Davis, Susan H., Murugesan, Dinakaran, Mathieson, Michael, Caldwell, Nicola, Engelhart, Curtis A., Schnappinger, Dirk, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Massoudi, Lisa, Robertson, Gregory T., Lenaerts, Anne J., Freiberg, Gail, Kempf, Dale J., Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Read, Kevin D., Green, Simon R., Wyatt, Paul G., Parish, Tanya
Publicado 2021