MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation

por Godfrey, Laura, Kerry, Jon, Thorne, Ross, Repapi, Emmanouela, Davies, James O.J., Tapia, Marta, Ballabio, Erica, Hughes, Jim R., Geng, Huimin, Konopleva, Marina, Milne, Thomas A.
Publicado 2017

BET inhibition disrupts transcription but retains enhancer-promoter contact

por Crump, Nicholas T., Ballabio, Erica, Godfrey, Laura, Thorne, Ross, Repapi, Emmanouela, Kerry, Jon, Tapia, Marta, Hua, Peng, Lagerholm, Christoffer, Filippakopoulos, Panagis, Davies, James O. J., Milne, Thomas A.
Publicado 2021

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

por Wilkinson, Adam C., Ballabio, Erica, Geng, Huimin, North, Phillip, Tapia, Marta, Kerry, Jon, Biswas, Debabrata, Roeder, Robert G., Allis, C. David, Melnick, Ari, de Bruijn, Marella F.T.R., Milne, Thomas A.
Publicado 2013

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

por Kerry, Jon, Godfrey, Laura, Repapi, Emmanouela, Tapia, Marta, Blackledge, Neil P., Ma, Helen, Ballabio, Erica, O’Byrne, Sorcha, Ponthan, Frida, Heidenreich, Olaf, Roy, Anindita, Roberts, Irene, Konopleva, Marina, Klose, Robert J., Geng, Huimin, Milne, Thomas A.
Publicado 2017

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia

por Numata, Akihiko, Kwok, Hui Si, Kawasaki, Akira, Li, Jia, Zhou, Qi-Ling, Kerry, Jon, Benoukraf, Touati, Bararia, Deepak, Li, Feng, Ballabio, Erica, Tapia, Marta, Deshpande, Aniruddha J., Welner, Robert S., Delwel, Ruud, Yang, Henry, Milne, Thomas A., Taneja, Reshma, Tenen, Daniel G.
Publicado 2018

Dynamics of the 4D genome during in vivo lineage specification and differentiation

por Oudelaar, A. Marieke, Beagrie, Robert A., Gosden, Matthew, de Ornellas, Sara, Georgiades, Emily, Kerry, Jon, Hidalgo, Daniel, Carrelha, Joana, Shivalingam, Arun, El-Sagheer, Afaf H., Telenius, Jelena M., Brown, Tom, Buckle, Veronica J., Socolovsky, Merav, Higgs, Douglas R., Hughes, Jim R.
Publicado 2020

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

por Mettananda, Sachith, Fisher, Chris A., Hay, Deborah, Badat, Mohsin, Quek, Lynn, Clark, Kevin, Hublitz, Philip, Downes, Damien, Kerry, Jon, Gosden, Matthew, Telenius, Jelena, Sloane-Stanley, Jackie A., Faustino, Paula, Coelho, Andreia, Doondeea, Jessica, Usukhbayar, Batchimeg, Sopp, Paul, Sharpe, Jacqueline A., Hughes, Jim R., Vyas, Paresh, Gibbons, Richard J., Higgs, Douglas R.
Publicado 2017

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

por Downes, Damien J., Beagrie, Robert A., Gosden, Matthew E., Telenius, Jelena, Carpenter, Stephanie J., Nussbaum, Lea, De Ornellas, Sara, Sergeant, Martin, Eijsbouts, Chris Q., Schwessinger, Ron, Kerry, Jon, Roberts, Nigel, Shivalingam, Arun, El-Sagheer, Afaf, Oudelaar, A. Marieke, Brown, Tom, Buckle, Veronica J., Davies, James O. J., Hughes, Jim R.
Publicado 2021

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199

por Benito, Juliana M., Godfrey, Laura, Kojima, Kensuke, Hogdal, Leah, Wunderlich, Mark, Geng, Huimin, Marzo, Isabel, Harutyunyan, Karine G., Golfman, Leonard, North, Phillip, Kerry, Jon, Ballabio, Erica, Chonghaile, Triona Ní, Gonzalo, Oscar, Qiu, Yihua, Jeremias, Irmela, Debose, LaKiesha, O’Brien, Eric, Ma, Helen, Zhou, Ping, Jacamo, Rodrigo, Park, Eugene, Coombes, Kevin R., Zhang, Nianxiang, Thomas, Deborah A., O’Brien, Susan, Kantarjian, Hagop M., Leverson, Joel D., Kornblau, Steven M., Andreeff, Michael, Müschen, Markus, Zweidler-McKay, Patrick A., Mulloy, James C., Letai, Anthony, Milne, Thomas A., Konopleva, Marina
Publicado 2015