Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes

por Jennings, Martin D, Kershaw, Christopher J, Adomavicius, Tomas, Pavitt, Graham D
Publicado 2017

mRNA localization to Pbodies in yeast is biphasic with many mRNAs captured in a late Bfr1pdependent wave

por Simpson, Clare E., Lui, Jennifer, Kershaw, Christopher J., Sims, Paul F. G., Ashe, Mark P.
Publicado 2014

Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs

por Jennings, Martin D, Srivastava, Priya, Kershaw, Christopher J, Talavera, David, Grant, Christopher M, Pavitt, Graham D
Publicado 2023

GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity

por Kershaw, Christopher J., Jennings, Martin D., Cortopassi, Francesco, Guaita, Margherita, Al-Ghafli, Hawra, Pavitt, Graham D.
Publicado 2021

Overlapping regions of Caf20 mediate its interactions with the mRNA-5′cap-binding protein eIF4E and with ribosomes

por Nwokoye, Ebelechukwu C., AlNaseem, Eiman, Crawford, Robert A., Castelli, Lydia M., Jennings, Martin D., Kershaw, Christopher J., Pavitt, Graham D.
Publicado 2021

Paralogous translation factors target distinct mRNAs to differentially regulate tolerance to oxidative stress in yeast

por Cunningham, Joanne, Sfakianos, Aristeidis P, Kritsiligkou, Paraskevi, Kershaw, Christopher J, Whitmarsh, Alan J, Hubbard, Simon J, Ashe, Mark P, Grant, Chris M
Publicado 2023

Integrated multi-omics reveals common properties underlying stress granule and P-body formation

por Kershaw, Christopher J., Nelson, Michael G., Lui, Jennifer, Bates, Christian P., Jennings, Martin D., Hubbard, Simon J., Ashe, Mark P., Grant, Chris M.
Publicado 2021

eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control

por Jennings, Martin D., Kershaw, Christopher J., White, Christopher, Hoyle, Danielle, Richardson, Jonathan P., Costello, Joseph L., Donaldson, Ian J., Zhou, Yu, Pavitt, Graham D.
Publicado 2016

Puf3p induces translational repression of genes linked to oxidative stress

por Rowe, William, Kershaw, Christopher J., Castelli, Lydia M., Costello, Joseph L., Ashe, Mark P., Grant, Christopher M., Sims, Paul F. G., Pavitt, Graham D., Hubbard, Simon J.
Publicado 2014

Translation factor and RNA binding protein mRNA interactomes support broader RNA regulons for posttranscriptional control

por Kershaw, Christopher J., Nelson, Michael G., Castelli, Lydia M., Jennings, Martin D., Lui, Jennifer, Talavera, David, Grant, Chris M., Pavitt, Graham D., Hubbard, Simon J., Ashe, Mark P.
Publicado 2023

The Yeast La Related Protein Slf1p Is a Key Activator of Translation during the Oxidative Stress Response

por Kershaw, Christopher J., Costello, Joseph L., Castelli, Lydia M., Talavera, David, Rowe, William, Sims, Paul F. G., Ashe, Mark P., Hubbard, Simon J., Pavitt, Graham D., Grant, Chris M.
Publicado 2015

Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p

por Kershaw, Christopher J., Costello, Joseph L., Talavera, David, Rowe, William, Castelli, Lydia M., Sims, Paul F. G., Grant, Christopher M., Ashe, Mark P., Hubbard, Simon J., Pavitt, Graham D.
Publicado 2015

Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses

por Costello, Joseph L., Kershaw, Christopher J., Castelli, Lydia M., Talavera, David, Rowe, William, Sims, Paul F. G., Ashe, Mark P., Grant, Christopher M., Hubbard, Simon J., Pavitt, Graham D.
Publicado 2017

Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions

por Talavera, David, Kershaw, Christopher J., Costello, Joseph L., Castelli, Lydia M., Rowe, William, Sims, Paul F. G., Ashe, Mark P., Grant, Chris M., Pavitt, Graham D., Hubbard, Simon J.
Publicado 2018

Global mRNA selection mechanisms for translation initiation

por Costello, Joseph, Castelli, Lydia M, Rowe, William, Kershaw, Christopher J, Talavera, David, Mohammad-Qureshi, Sarah S, Sims, Paul F G, Grant, Christopher M, Pavitt, Graham D, Hubbard, Simon J, Ashe, Mark P
Publicado 2015

The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation

por Castelli, Lydia M., Talavera, David, Kershaw, Christopher J., Mohammad-Qureshi, Sarah S., Costello, Joseph L., Rowe, William, Sims, Paul F. G., Grant, Christopher M., Hubbard, Simon J., Ashe, Mark P., Pavitt, Graham D.
Publicado 2015

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

por Falletta, Paola, Sanchez-del-Campo, Luis, Chauhan, Jagat, Effern, Maike, Kenyon, Amy, Kershaw, Christopher J., Siddaway, Robert, Lisle, Richard, Freter, Rasmus, Daniels, Matthew J., Lu, Xin, Tüting, Thomas, Middleton, Mark, Buffa, Francesca M., Willis, Anne E., Pavitt, Graham, Ronai, Ze'ev A., Sauka-Spengler, Tatjana, Hölzel, Michael, Goding, Colin R.
Publicado 2017

Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts

por Jenkinson, Emma M., Rodero, Mathieu P., Kasher, Paul R., Uggenti, Carolina, Oojageer, Anthony, Goosey, Laurence C., Rose, Yohann, Kershaw, Christopher J., Urquhart, Jill E., Williams, Simon G., Bhaskar, Sanjeev S., O’Sullivan, James, Baerlocher, Gabriela M., Haubitz, Monika, Aubert, Geraldine, Barañano, Kristin W., Barnicoat, Angela J., Battini, Roberta, Berger, Andrea, Blair, Edward M., Brunstrom-Hernandez, Janice E., Buckard, Johannes A., Cassiman, David M., Caumes, Rosaline, Cordelli, Duccio M., De Waele, Liesbeth M., Fay, Alexander J., Ferreira, Patrick, Fletcher, Nicholas A., Fryer, Alan E., Goel, Himanshu, Hemingway, Cheryl A., Henneke, Marco, Hughes, Imelda, Jefferson, Rosalind J., Kumar, Ram, Lagae, Lieven, Landrieu, Pierre G., Lourenço, Charles M., Malpas, Timothy J., Mehta, Sarju G., Metz, Imke, Naidu, Sakkubai, Õunap, Katrin, Panzer, Axel, Prabhakar, Prab, Quaghebeur, Geraldine, Schiffmann, Raphael, Sherr, Elliott H., Sinnathuray, Kanaga R., Soh, Calvin, Stewart, Helen S., Stone, John, Van Esch, Hilde, Van Mol, Christine E.G., Vanderver, Adeline, Wakeling, Emma L., Whitney, Andrea, Pavitt, Graham D., Griffiths-Jones, Sam, Rice, Gillian I., Revy, Patrick, van der Knaap, Marjo S., Livingston, John H., O’Keefe, Raymond T., Crow, Yanick J.
Publicado 2016