The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis

por Morris, Rhiannon, Butler, Liesl, Perkins, Andrew, Kershaw, Nadia J., Babon, Jeffrey J.
Publicado 2021

Independent Interactions of Phosphorylated β-Catenin with E-Cadherin at Cell-Cell Contacts and APC at Cell Protrusions

por Faux, Maree C., Coates, Janine L., Kershaw, Nadia J., Layton, Meredith J., Burgess, Antony W.
Publicado 2010

Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases

por Muniz, João R.C., Guo, Kunde, Kershaw, Nadia J., Ayinampudi, Vikram, von Delft, Frank, Babon, Jeffrey J., Bullock, Alex N.
Publicado 2013

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

por Liau, Nicholas P. D., Laktyushin, Artem, Morris, Rhiannon, Sandow, Jarrod J., Nicola, Nicos A., Kershaw, Nadia J., Babon, Jeffrey J.
Publicado 2019

Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK

por Morris, Rhiannon, Zhang, Yaoyuan, Ellyard, Julia I., Vinuesa, Carola G., Murphy, James M., Laktyushin, Artem, Kershaw, Nadia J., Babon, Jeffrey J.
Publicado 2021

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine

por Li, Kunlun, Meza Guzman, Lizeth G., Whitehead, Lachlan, Leong, Evelyn, Kueh, Andrew, Alexander, Warren S., Kershaw, Nadia J., Babon, Jeffrey J., Doggett, Karen, Nicholson, Sandra E.
Publicado 2022

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

por Kershaw, Nadia J., Murphy, James M., Liau, Nicholas P.D., Varghese, Leila N., Laktyushin, Artem, Whitlock, Eden L., Lucet, Isabelle S., Nicola, Nicos A., Babon, Jeffrey J.
Publicado 2013

The molecular basis of JAK/STAT inhibition by SOCS1

por Liau, Nicholas P. D., Laktyushin, Artem, Lucet, Isabelle S., Murphy, James M., Yao, Shenggen, Whitlock, Eden, Callaghan, Kimberley, Nicola, Nicos A., Kershaw, Nadia J., Babon, Jeffrey J.
Publicado 2018

Structure guided studies of the interaction between PTP1B and JAK

por Morris, Rhiannon, Keating, Narelle, Tan, Cyrus, Chen, Hao, Laktyushin, Artem, Saiyed, Tamanna, Liau, Nicholas P. D., Nicola, Nicos A., Tiganis, Tony, Kershaw, Nadia J., Babon, Jeffrey J.
Publicado 2023

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

por Liang, Shuwei, Tran, Eric, Du, Xin, Dong, Jiajun, Sudholz, Harrison, Chen, Hao, Qu, Zihan, Huntington, Nicholas D., Babon, Jeffrey J., Kershaw, Nadia J., Zhang, Zhong-Yin, Baell, Jonathan B., Wiede, Florian, Tiganis, Tony
Publicado 2023

Diversity in the intrinsic apoptosis pathway of nematodes

por Young, Neil D., Harris, Tiffany J., Evangelista, Marco, Tran, Sharon, Wouters, Merridee A., Soares da Costa, Tatiana P., Kershaw, Nadia J., Gasser, Robin B., Smith, Brian J., Lee, Erinna F., Fairlie, W. Douglas
Publicado 2020

Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

por Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J., Nicholson, Sandra E.
Publicado 2023

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

por Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J., Nicholson, Sandra E.
Publicado 2021

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

por Pfeffer, Inga, Brewitz, Lennart, Krojer, Tobias, Jensen, Sacha A., Kochan, Grazyna T., Kershaw, Nadia J., Hewitson, Kirsty S., McNeill, Luke A., Kramer, Holger, Münzel, Martin, Hopkinson, Richard J., Oppermann, Udo, Handford, Penny A., McDonough, Michael A., Schofield, Christopher J.
Publicado 2019

Correction to: S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer

por Low, Ronnie Ren Jie, Fung, Ka Yee, Gao, Hugh, Preaudet, Adele, Dagley, Laura F., Yousef, Jumana, Lee, Belinda, Emery-Corbin, Samantha J., Nguyen, Paul M., Larsen, Rune H., Kershaw, Nadia J., Burgess, Antony W., Gibbs, Peter, Hollande, Frédéric, Griffin, Michael D. W., Grimmond, Sean M., Putoczki, Tracy L.
Publicado 2023

S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer

por Low, Ronnie Ren Jie, Fung, Ka Yee, Gao, Hugh, Preaudet, Adele, Dagley, Laura F., Yousef, Jumana, Lee, Belinda, Emery-Corbin, Samantha J., Nguyen, Paul M., Larsen, Rune H., Kershaw, Nadia J., Burgess, Antony W., Gibbs, Peter, Hollande, Frédéric, Griffin, Michael D. W., Grimmond, Sean M., Putoczki, Tracy L.
Publicado 2023

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

por Ramiscal, Roybel R, Parish, Ian A, Lee-Young, Robert S, Babon, Jeffrey J, Blagih, Julianna, Pratama, Alvin, Martin, Jaime, Hawley, Naomi, Cappello, Jean Y, Nieto, Pablo F, Ellyard, Julia I, Kershaw, Nadia J, Sweet, Rebecca A, Goodnow, Christopher C, Jones, Russell G, Febbraio, Mark A, Vinuesa, Carola G, Athanasopoulos, Vicki
Publicado 2015

Ribosomal Oxygenases are Structurally Conserved from Prokaryotes to Humans

por Chowdhury, Rasheduzzaman, Sekirnik, Rok, Brissett, Nigel C., Krojer, Tobias, Ho, Chia-hua, Ng, Stanley S., Clifton, Ian J., Ge, Wei, Kershaw, Nadia J., Fox, Gavin C., Muniz, Joao R. C., Vollmar, Melanie, Phillips, Claire, Pilka, Ewa S., Kavanagh, Kathryn L., von Delft, Frank, Oppermann, Udo, McDonough, Michael A., Doherty, Aiden J., Schofield, Christopher J.
Publicado 2014

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

por Srivastava, Monika, Duan, Guowen, Kershaw, Nadia J., Athanasopoulos, Vicki, Yeo, Janet H. C., Ose, Toyoyuki, Hu, Desheng, Brown, Simon H. J., Jergic, Slobodan, Patel, Hardip R., Pratama, Alvin, Richards, Sashika, Verma, Anil, Jones, E. Yvonne, Heissmeyer, Vigo, Preiss, Thomas, Dixon, Nicholas E., Chong, Mark M. W., Babon, Jeffrey J., Vinuesa, Carola G.
Publicado 2015

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

por Grohmann, Christoph, Walker, Francesca, Devlin, Mark, Luo, Meng-Xiao, Chüeh, Anderly C., Doherty, Judy, Vaillant, François, Ho, Gwo-Yaw, Wakefield, Matthew J., Weeden, Clare E., Kamili, Alvin, Murray, Jayne, Po’uha, Sela T., Weinstock, Janet, Kane, Serena R., Faux, Maree C., Broekhuizen, Esmee, Zheng, Ye, Shield-Artin, Kristy, Kershaw, Nadia J., Tan, Chin Wee, Witchard, Helen M., Ebert, Gregor, Charman, Susan A., Street, Ian, Kavallaris, Maria, Haber, Michelle, Fletcher, Jamie I., Asselin-Labat, Marie-Liesse, Scott, Clare L., Visvader, Jane E., Lindeman, Geoffrey J., Watson, Keith G., Burgess, Antony W., Lessene, Guillaume
Publicado 2021