Sinapic Acid Attenuates the Neuroinflammatory Response by Targeting AKT and MAPK in LPS-Activated Microglial Models

por Huang, Tianqi, Zhao, Dong, Lee, Sangbin, Keum, Gyochang, Yang, Hyun Ok
Publicado 2023

Sulfur(vi) fluoride exchange as a key reaction for synthesizing biaryl sulfate core derivatives as potent hepatitis C virus NS5A inhibitors and their structure–activity relationshi...

por You, Youngsu, Kim, Hee Sun, Park, Jung Woo, Keum, Gyochang, Jang, Sung Key, Kim, B. Moon
Publicado 2018

Discovery of 3-((3-amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T3...

por El-Damasy, Ashraf K., Kim, Hyun Ji, Park, Jung Woo, Nam, Yunju, Hur, Wooyoung, Bang, Eun-Kyoung, Keum, Gyochang
Publicado 2023

Identification of New N-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors

por El-Damasy, Ashraf K., Park, Jong Eun, Kim, Hyun Ji, Lee, Jinhyuk, Bang, Eun-Kyoung, Kim, Hoon, Keum, Gyochang
Publicado 2023

Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII

por El-Damasy, Ashraf K., Kim, Hyun Ji, Nocentini, Alessio, Seo, Seon Hee, Eldehna, Wagdy M., Bang, Eun-Kyoung, Supuran, Claudiu T., Keum, Gyochang
Publicado 2023

Design and Synthesis of New 4-(3,4,5-Trimethoxyphenyl)Thiazole–Pyrimidine Derivatives as Potential Antiproliferative Agents

por El-Damasy, Ashraf K., Jin, Heewon, Sabry, Mohamed A., Kim, Hyun Ji, Alanazi, Mohammed M., Seo, Seon Hee, Bang, Eun-Kyoung, Keum, Gyochang
Publicado 2023

Discovery of New Quinolone-Based Diarylamides as Potent B-RAF(V600E)/C-RAF Kinase Inhibitors Endowed with Promising In Vitro Anticancer Activity

por Kim, Hyun Ji, Park, Jung Woo, Seo, Sangjae, Cho, Kwang-Hwi, Alanazi, Mohammed M., Bang, Eun-Kyoung, Keum, Gyochang, El-Damasy, Ashraf K.
Publicado 2023

Overcoming the imatinib-resistant BCR-ABL mutants with new ureidobenzothiazole chemotypes endowed with potent and broad-spectrum anticancer activity

por El-Damasy, Ashraf K., Jin, Heewon, Park, Jung Woo, Kim, Hyun Ji, Khojah, Hanan, Seo, Seon Hee, Lee, Ju-Hyeon, Bang, Eun-Kyoung, Keum, Gyochang
Publicado 2023

Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90

por Shin, Sang Chul, El-Damasy, Ashraf K., Lee, Ju Hyeon, Seo, Seon Hee, Kim, Ji Hyun, Seo, Young Ho, Lee, Yuri, Yu, Ji Hoon, Bang, Eun Kyoung, Kim, Eunice EunKyeong, Keum, Gyochang
Publicado 2020

Analyzing immune responses to varied mRNA and protein vaccine sequences

por Park, Hyeong-Jun, Bang, Yoo-Jin, Kwon, Sung Pil, Kwak, Woori, Park, Sang-In, Roh, Gahyun, Bae, Seo-Hyeon, Kim, Jae-Yong, Kwak, Hye Won, Kim, Yongkwan, Yoo, Soyeon, Kim, Daegeun, Keum, Gyochang, Bang, Eun-Kyoung, Hong, So-Hee, Nam, Jae-Hwan
Publicado 2023