Functional analysis of four LDLR 5′UTR and promoter variants in patients with familial hypercholesterolaemia

por Khamis, Amna, Palmen, Jutta, Lench, Nick, Taylor, Alison, Badmus, Ebele, Leigh, Sarah, Humphries, Steve E
Publicado 2015

Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect

por Khamis, Amna, Boutry, Raphael, Canouil, Mickaël, Mathew, Sumi, Lobbens, Stephane, Crouch, Hutokshi, Andrew, Toby, Abderrahmani, Amar, Tamanini, Filippo, Froguel, Philippe
Publicado 2020

Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function

por Hu, Ming, Kim, Innah, Morán, Ignasi, Peng, Weicong, Sun, Orien, Bonnefond, Amélie, Khamis, Amna, Bonas-Guarch, Silvia, Froguel, Philippe, Rutter, Guy A.
Publicado 2023

Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes

por Maina, Jared G., Balkhiyarova, Zhanna, Nouwen, Arie, Pupko, Igor, Ulrich, Anna, Boissel, Mathilde, Bonnefond, Amélie, Froguel, Philippe, Khamis, Amna, Prokopenko, Inga, Kaakinen, Marika
Publicado 2023

Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome

por Canouil, Mickaël, Khamis, Amna, Keikkala, Elina, Hummel, Sandra, Lobbens, Stephane, Bonnefond, Amélie, Delahaye, Fabien, Tzala, Evangelia, Mustaniemi, Sanna, Vääräsmäki, Marja, Jarvelin, Marjo-Riitta, Sebert, Sylvain, Kajantie, Eero, Froguel, Philippe, Andrew, Toby
Publicado 2021

The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward

por Ndiaye, Fatou K, Huyvaert, Marlène, Ortalli, Ana, Canouil, Mickaël, Lecoeur, Cécile, Verbanck, Marie, Lobbens, Stéphane, Khamis, Amna, Marselli, Lorella, Marchetti, Piero, Kerr-Conte, Julie, Pattou, François, Marre, Michel, Roussel, Ronan, Balkau, Beverley, Froguel, Philippe, Bonnefond, Amélie
Publicado 2019

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

por Khamis, Amna, Canouil, Mickaël, Siddiq, Afshan, Crouch, Hutokshi, Falchi, Mario, Bulow, Manon von, Ehehalt, Florian, Marselli, Lorella, Distler, Marius, Richter, Daniela, Weitz, Jürgen, Bokvist, Krister, Xenarios, Ioannis, Thorens, Bernard, Schulte, Anke M., Ibberson, Mark, Bonnefond, Amelie, Marchetti, Piero, Solimena, Michele, Froguel, Philippe
Publicado 2019

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion

por Hu, Ming, Cebola, Inês, Carrat, Gaelle, Jiang, Shuying, Nawaz, Sameena, Khamis, Amna, Canouil, Mickaël, Froguel, Philippe, Schulte, Anke, Solimena, Michele, Ibberson, Mark, Marchetti, Piero, Cardenas-Diaz, Fabian L., Gadue, Paul J., Hastoy, Benoit, Alemeida-Souza, Leonardo, McMahon, Harvey, Rutter, Guy A.
Publicado 2021

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion

por Hu, Ming, Cebola, Inês, Carrat, Gaelle, Jiang, Shuying, Nawaz, Sameena, Khamis, Amna, Canouil, Mickaël, Froguel, Philippe, Schulte, Anke, Solimena, Michele, Ibberson, Mark, Marchetti, Piero, Cardenas-Diaz, Fabian L., Gadue, Paul J., Hastoy, Benoit, Almeida-Souza, Leonardo, McMahon, Harvey, Rutter, Guy A.
Publicado 2021

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

por Tobi, Elmar W., Juvinao-Quintero, Diana L., Ronkainen, Justiina, Ott, Raffael, Alfano, Rossella, Canouil, Mickaël, Geurtsen, Madelon L., Khamis, Amna, Küpers, Leanne K., Lim, Ives Y., Perron, Patrice, Pesce, Giancarlo, Tuhkanen, Johanna, Starling, Anne P., Andrew, Toby, Binder, Elisabeth, Caiazzo, Robert, Chan, Jerry K.Y., Gaillard, Romy, Gluckman, Peter D., Keikkala, Elina, Karnani, Neerja, Mustaniemi, Sanna, Nawrot, Tim S., Pattou, François, Plusquin, Michelle, Raverdy, Violeta, Tan, Kok Hian, Tzala, Evangelia, Raikkonen, Katri, Winkler, Christiane, Ziegler, Anette-G., Annesi-Maesano, Isabella, Bouchard, Luigi, Chong, Yap Seng, Dabelea, Dana, Felix, Janine F., Heude, Barbara, Jaddoe, Vincent W.V., Lahti, Jari, Reimann, Brigitte, Vääräsmäki, Marja, Bonnefond, Amélie, Froguel, Philippe, Hummel, Sandra, Kajantie, Eero, Jarvelin, Marjo-Riita, Steegers-Theunissen, Regine P.M., Howe, Caitlin G., Hivert, Marie-France, Sebert, Sylvain
Publicado 2022

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

por Pervjakova, Natalia, Moen, Gunn-Helen, Borges, Maria-Carolina, Ferreira, Teresa, Cook, James P, Allard, Catherine, Beaumont, Robin N, Canouil, Mickaël, Hatem, Gad, Heiskala, Anni, Joensuu, Anni, Karhunen, Ville, Kwak, Soo Heon, Lin, Frederick T J, Liu, Jun, Rifas-Shiman, Sheryl, Tam, Claudia H, Tam, Wing Hung, Thorleifsson, Gudmar, Andrew, Toby, Auvinen, Juha, Bhowmik, Bishwajit, Bonnefond, Amélie, Delahaye, Fabien, Demirkan, Ayse, Froguel, Philippe, Haller-Kikkatalo, Kadri, Hardardottir, Hildur, Hummel, Sandra, Hussain, Akhtar, Kajantie, Eero, Keikkala, Elina, Khamis, Amna, Lahti, Jari, Lekva, Tove, Mustaniemi, Sanna, Sommer, Christine, Tagoma, Aili, Tzala, Evangelia, Uibo, Raivo, Vääräsmäki, Marja, Villa, Pia M, Birkeland, Kåre I, Bouchard, Luigi, Duijn, Cornelia M, Finer, Sarah, Groop, Leif, Hämäläinen, Esa, Hayes, Geoffrey M, Hitman, Graham A, Jang, Hak C, Järvelin, Marjo-Riitta, Jenum, Anne Karen, Laivuori, Hannele, Ma, Ronald C, Melander, Olle, Oken, Emily, Park, Kyong Soo, Perron, Patrice, Prasad, Rashmi B, Qvigstad, Elisabeth, Sebert, Sylvain, Stefansson, Kari, Steinthorsdottir, Valgerdur, Tuomi, Tiinamaija, Hivert, Marie-France, Franks, Paul W, McCarthy, Mark I, Lindgren, Cecilia M, Freathy, Rachel M, Lawlor, Deborah A, Morris, Andrew P, Mägi, Reedik
Publicado 2022