iMEGES: integrated mental-disorder GEnome score by deep neural network for prioritizing the susceptibility genes for mental disorders in personal genomes

por Khan, Atlas, Liu, Qian, Wang, Kai
Publicado 2018

BIGKnock: fine-mapping gene-based associations via knockoff analysis of biobank-scale data

por Ma, Shiyang, Wang, Chen, Khan, Atlas, Liu, Linxi, Dalgleish, James, Kiryluk, Krzysztof, He, Zihuai, Ionita-Laza, Iuliana
Publicado 2023

Polygenic risk affects the penetrance of monogenic kidney disease

por Khan, Atlas, Shang, Ning, Nestor, Jordan G., Weng, Chunhua, Hripcsak, George, Harris, Peter C., Gharavi, Ali G., Kiryluk, Krzysztof
Publicado 2023

Detection of human papillomavirus in cases of head and neck squamous cell carcinoma by RNA‐seq and VirTect

por Khan, Atlas, Liu, Qian, Chen, Xuelian, Stucky, Andres, Sedghizadeh, Parish P., Adelpour, Daniel, Zhang, Xi, Wang, Kai, Zhong, Jiang F.
Publicado 2019

Alternative splicing of OAS1 alters the risk for severe COVID-19

por Huffman, Jennifer, Butler-Laporte, Guillaume, Khan, Atlas, Drivas, Theodore G., Peloso, Gina M., Nakanishi, Tomoko, Verma, Anurag, Kiryluk, Krzysztof, Richards, J. Brent, Zeberg, Hugo
Publicado 2021

Quantitative disease risk scores from EHR with applications to clinical risk stratification and genetic studies

por Xu, Danqing, Wang, Chen, Khan, Atlas, Shang, Ning, He, Zihuai, Gordon, Adam, Kullo, Iftikhar J., Murphy, Shawn, Ni, Yizhao, Wei, Wei-Qi, Gharavi, Ali, Kiryluk, Krzysztof, Weng, Chunhua, Ionita-Laza, Iuliana
Publicado 2021

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

por Huffman, Jennifer E., Butler-Laporte, Guillaume, Khan, Atlas, Pairo-Castineira, Erola, Drivas, Theodore G., Peloso, Gina M., Nakanishi, Tomoko, Ganna, Andrea, Verma, Anurag, Baillie, J. Kenneth, Kiryluk, Krzysztof, Richards, J. Brent, Zeberg, Hugo
Publicado 2022

Cystatin C is associated with adverse COVID-19 outcomes in diverse populations

por Kleeman, Sam O., Cordioli, Mattia, Timmers, Paul R.H. J., Khan, Atlas, Tober-Lau, Pinkus, Kurth, Florian, Demichev, Vadim, Meyer, Hannah V., Wilson, James F., Ralser, Markus, Kiryluk, Krzysztof, Ganna, Andrea, Baillie, Kenneth, Janowitz, Tobias
Publicado 2022

A metadata framework for computational phenotypes

por Spotnitz, Matthew, Acharya, Nripendra, Cimino, James J, Murphy, Shawn, Namjou, Bahram, Crimmins, Nancy, Walunas, Theresa, Liu, Cong, Crosslin, David, Benoit, Barbara, Rosenthal, Elisabeth, Pacheco, Jennifer A, Ostropolets, Anna, Reyes Nieva, Harry, Patterson, Jason S, Richter, Lauren R, Callahan, Tiffany J, Elhussein, Ahmed, Pang, Chao, Kiryluk, Krzysztof, Nestor, Jordan, Khan, Atlas, Mohan, Sumit, Minty, Evan, Chung, Wendy, Wei, Wei-Qi, Natarajan, Karthik, Weng, Chunhua
Publicado 2023

Generalizability of Polygenic Risk Scores for Breast Cancer Among Women With European, African, and Latinx Ancestry

por Liu, Cong, Zeinomar, Nur, Chung, Wendy K., Kiryluk, Krzysztof, Gharavi, Ali G., Hripcsak, George, Crew, Katherine D., Shang, Ning, Khan, Atlas, Fasel, David, Manolio, Teri A., Jarvik, Gail P., Rowley, Robb, Justice, Ann E., Rahm, Alanna K., Fullerton, Stephanie M., Smoller, Jordan W., Larson, Eric B., Crane, Paul K., Dikilitas, Ozan, Wiesner, Georgia L., Bick, Alexander G., Terry, Mary Beth, Weng, Chunhua
Publicado 2021

Clinical consequences of a polygenic predisposition to benign lower white blood cell counts: Consequences of benign WBC count genetics

por Mosley, Jonathan D., Shelley, John P., Dickson, Alyson L., Zanussi, Jacy, Daniel, Laura L., Zheng, Neil S., Bastarache, Lisa, Wei, Wei-Qi, Shi, Mingjian, Jarvik, Gail P., Rosenthal, Elisabeth A., Khan, Atlas, Sherafati, Alborz, Kullo, Iftikhar J., Walunas, Theresa L., Glessner, Joe, Hakonarson, Hakon, Cox, Nancy J., Roden, Dan M., Frangakis, Stephan G., Vanderwerff, Brett, Stein, C. Michael, Van Driest, Sara L., Borinstein, Scott C., Shu, Xiao-Ou, Zawistowski, Matthew, Chung, Cecilia P., Kawai, Vivian K.
Publicado 2023

Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum

por Lee, David S.M., Cardone, Katie M., Zhang, David Y., Abramowitz, Sarah, DePaolo, John S., Aragam, Krishna G., Biddinger, Kiran, Conery, Mitchell, Dilitikas, Ozan, Hoffman-Andrews, Lily, Judy, Renae L., Khan, Atlas, Kulo, Iftikhar, Puckelwartz, Megan J., Reza, Nosheen, Satterfield, Benjamin A., Singhal, Pankhuri, Arany, Zoltan P., Cappola, Thomas P., Carruth, Eric, Day, Sharlene M., Do, Ron, Haggarty, Christopher M., Joseph, Jacob, McNally, Elizabeth, Nadkarni, Girish, Owens, Anjali T., Rader, Daniel J., Ritchie, Marylyn D., Sun, Yan, Voight, Benjamin F., Levin, Michael G., Damrauer, Scott M.
Publicado 2023

Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies

por Shang, Ning, Khan, Atlas, Polubriaginof, Fernanda, Zanoni, Francesca, Mehl, Karla, Fasel, David, Drawz, Paul E., Carrol, Robert J., Denny, Joshua C., Hathcock, Matthew A., Arruda-Olson, Adelaide M., Peissig, Peggy L., Dart, Richard A., Brilliant, Murray H., Larson, Eric B., Carrell, David S., Pendergrass, Sarah, Verma, Shefali Setia, Ritchie, Marylyn D., Benoit, Barbara, Gainer, Vivian S., Karlson, Elizabeth W., Gordon, Adam S., Jarvik, Gail P., Stanaway, Ian B., Crosslin, David R., Mohan, Sumit, Ionita-Laza, Iuliana, Tatonetti, Nicholas P., Gharavi, Ali G., Hripcsak, George, Weng, Chunhua, Kiryluk, Krzysztof
Publicado 2021

Failure to replicate the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19

por Povysil, Gundula, Butler-Laporte, Guillaume, Shang, Ning, Weng, Chen, Khan, Atlas, Alaamery, Manal, Nakanishi, Tomoko, Zhou, Sirui, Forgetta, Vincenzo, Eveleigh, Robert, Bourgey, Mathieu, Aziz, Naveed, Jones, Steven, Knoppers, Bartha, Scherer, Stephen, Strug, Lisa, Lepage, Pierre, Ragoussis, Jiannis, Bourque, Guillaume, Alghamdi, Jahad, Aljawini, Nora, Albes, Nour, Al-Afghani, Hani M., Alghamdi, Bader, Almutair, Mansour, Mahmoud, Ebrahim Sabri, Safie, Leen Abu, Bardisy, Hadeel El, Al Harthi, Fawz S., Alshareef, Abdulraheem, Suliman, Bandar Ali, Alqahtani, Saleh, AlMalik, Abdulaziz, Alrashed, May M., Massadeh, Salam, Mooser, Vincent, Lathrop, Mark, Arabi, Yaseen, Mbarek, Hamdi, Saad, Chadi, Al-Muftah, Wadha, Badji, Radja, Al Thani, Asma, Ismail, Said I., Gharavi, Ali G., Abedalthagafi, Malak S., Richards, J Brent, Goldstein, David B., Kiryluk, Krzysztof
Publicado 2020

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality

por Nakanishi, Tomoko, Pigazzini, Sara, Degenhardt, Frauke, Cordioli, Mattia, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Nafría-Jiménez, Beatriz, Bouysran, Youssef, Niemi, Mari, Palom, Adriana, Ellinghaus, David, Khan, Atlas, Martínez-Bueno, Manuel, Rolker, Selina, Amitano, Sara, Tato, Luisa Roade, Fava, Francesca, Spinner, Christoph D., Prati, Daniele, Bernardo, David, Garcia, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Holter, Jan Cato, Banales, Jesus, Frithiof, Robert, Kiryluk, Krzysztof, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C, Romero-Gómez, Manuel, Bujanda, Luis, Hov, Johannes R., Migeotte, Isabelle, Renieri, Alessandra, Planas, Anna M., Ludwig, Kerstin U., Buti, Maria, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Franke, Andre, Karlsen, Tom H, Valenti, Luca, Zeberg, Hugo, Richards, J. Brent, Ganna, Andrea
Publicado 2021

Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure

por Levin, Michael G., Tsao, Noah L., Singhal, Pankhuri, Liu, Chang, Vy, Ha My T., Paranjpe, Ishan, Backman, Joshua D., Bellomo, Tiffany R., Bone, William P., Biddinger, Kiran J., Hui, Qin, Dikilitas, Ozan, Satterfield, Benjamin A., Yang, Yifan, Morley, Michael P., Bradford, Yuki, Burke, Megan, Reza, Nosheen, Charest, Brian, Judy, Renae L., Puckelwartz, Megan J., Hakonarson, Hakon, Khan, Atlas, Kottyan, Leah C., Kullo, Iftikhar, Luo, Yuan, McNally, Elizabeth M., Rasmussen-Torvik, Laura J., Day, Sharlene M., Do, Ron, Phillips, Lawrence S., Ellinor, Patrick T., Nadkarni, Girish N., Ritchie, Marylyn D., Arany, Zoltan, Cappola, Thomas P., Margulies, Kenneth B., Aragam, Krishna G., Haggerty, Christopher M., Joseph, Jacob, Sun, Yan V., Voight, Benjamin F., Damrauer, Scott M.
Publicado 2022

Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

por Ge, Tian, Irvin, Marguerite R., Patki, Amit, Srinivasasainagendra, Vinodh, Lin, Yen-Feng, Tiwari, Hemant K., Armstrong, Nicole D., Benoit, Barbara, Chen, Chia-Yen, Choi, Karmel W., Cimino, James J., Davis, Brittney H., Dikilitas, Ozan, Etheridge, Bethany, Feng, Yen-Chen Anne, Gainer, Vivian, Huang, Hailiang, Jarvik, Gail P., Kachulis, Christopher, Kenny, Eimear E., Khan, Atlas, Kiryluk, Krzysztof, Kottyan, Leah, Kullo, Iftikhar J., Lange, Christoph, Lennon, Niall, Leong, Aaron, Malolepsza, Edyta, Miles, Ayme D., Murphy, Shawn, Namjou, Bahram, Narayan, Renuka, O’Connor, Mark J., Pacheco, Jennifer A., Perez, Emma, Rasmussen-Torvik, Laura J., Rosenthal, Elisabeth A., Schaid, Daniel, Stamou, Maria, Udler, Miriam S., Wei, Wei-Qi, Weiss, Scott T., Ng, Maggie C. Y., Smoller, Jordan W., Lebo, Matthew S., Meigs, James B., Limdi, Nita A., Karlson, Elizabeth W.
Publicado 2022

Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

por Liu, Lili, Khan, Atlas, Sanchez-Rodriguez, Elena, Zanoni, Francesca, Li, Yifu, Steers, Nicholas, Balderes, Olivia, Zhang, Junying, Krithivasan, Priya, LeDesma, Robert A., Fischman, Clara, Hebbring, Scott J., Harley, John B., Moncrieffe, Halima, Kottyan, Leah C., Namjou-Khales, Bahram, Walunas, Theresa L., Knevel, Rachel, Raychaudhuri, Soumya, Karlson, Elizabeth W., Denny, Joshua C., Stanaway, Ian B., Crosslin, David, Rauen, Thomas, Floege, Jürgen, Eitner, Frank, Moldoveanu, Zina, Reily, Colin, Knoppova, Barbora, Hall, Stacy, Sheff, Justin T., Julian, Bruce A., Wyatt, Robert J., Suzuki, Hitoshi, Xie, Jingyuan, Chen, Nan, Zhou, Xujie, Zhang, Hong, Hammarström, Lennart, Viktorin, Alexander, Magnusson, Patrik K. E., Shang, Ning, Hripcsak, George, Weng, Chunhua, Rundek, Tatjana, Elkind, Mitchell S. V., Oelsner, Elizabeth C., Barr, R. Graham, Ionita-Laza, Iuliana, Novak, Jan, Gharavi, Ali G., Kiryluk, Krzysztof
Publicado 2022

Author Correction: Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

por Liu, Lili, Khan, Atlas, Sanchez-Rodriguez, Elena, Zanoni, Francesca, Li, Yifu, Steers, Nicholas, Balderes, Olivia, Zhang, Junying, Krithivasan, Priya, LeDesma, Robert A., Fischman, Clara, Hebbring, Scott J., Harley, John B., Moncrieffe, Halima, Kottyan, Leah C., Namjou-Khales, Bahram, Walunas, Theresa L., Knevel, Rachel, Raychaudhuri, Soumya, Karlson, Elizabeth W., Denny, Joshua C., Stanaway, Ian B., Crosslin, David, Rauen, Thomas, Floege, Jürgen, Eitner, Frank, Moldoveanu, Zina, Reily, Colin, Knoppova, Barbora, Hall, Stacy, Sheff, Justin T., Julian, Bruce A., Wyatt, Robert J., Suzuki, Hitoshi, Xie, Jingyuan, Chen, Nan, Zhou, Xujie, Zhang, Hong, Hammarström, Lennart, Viktorin, Alexander, Magnusson, Patrik K. E., Shang, Ning, Hripcsak, George, Weng, Chunhua, Rundek, Tatjana, Elkind, Mitchell S. V., Oelsner, Elizabeth C., Barr, R. Graham, Ionita-Laza, Iuliana, Novak, Jan, Gharavi, Ali G., Kiryluk, Krzysztof
Publicado 2023

Selection, optimization, and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse populations

por Lennon, Niall J, Kottyan, Leah C, Kachulis, Christopher, Abul-Husn, Noura, Arias, Josh, Belbin, Gillian, Below, Jennifer E, Berndt, Sonja, Chung, Wendy, Cimino, James J., Clayton, Ellen Wright, Connolly, John J., Crosslin, David, Dikilitas, Ozan, Velez Edwards, Digna R., Feng, QiPing, Fisher, Marissa, Freimuth, Robert, Ge, Tian, Glessner, Joseph T., Gordon, Adam, Guiducci, Candace, Hakonarson, Hakon, Harden, Maegan, Harr, Margaret, Hirschhorn, Joel, Hoggart, Clive, Hsu, Li, Irvin, Ryan, Jarvik, Gail P., Karlson, Elizabeth W., Khan, Atlas, Khera, Amit, Kiryluk, Krzysztof, Kullo, Iftikhar, Larkin, Katie, Limdi, Nita, Linder, Jodell E., Loos, Ruth, Luo, Yuan, Malolepsza, Edyta, Manolio, Teri, Martin, Lisa J., McCarthy, Li, Meigs, James B, Mersha, Tesfaye B., Mosley, Jonathan, Namjou, Bahram, Pai, Nihal, Pesce, Lorenzo L., Peters, Ulrike, Peterson, Josh, Prows, Cynthia A., Puckelwartz, Megan J., Rehm, Heidi, Roden, Dan, Rosenthal, Elisabeth A., Rowley, Robb, Sawicki, Konrad Teodor, Schaid, Dan, Schmidlen, Tara, Smit, Roelof, Smith, Johanna, Smoller, Jordan W., Thomas, Minta, Tiwari, Hemant, Toledo, Diana, Vaitinadin, Nataraja Sarma, Veenstra, David, Walunas, Theresa, Wang, Zhe, Wei, Wei-Qi, Weng, Chunhua, Wiesner, Georgia, Xianyong, Yin, Kenny, Eimear
Publicado 2023