Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins

por Khan, Naazneen, de Manuel, Marc, Peyregne, Stephane, Do, Raymond, Prufer, Kay, Marques-Bonet, Tomas, Varki, Nissi, Gagneux, Pascal, Varki, Ajit
Publicado 2020

Evolution of Human-Specific Alleles Protecting Cognitive Function of Grandmothers

por Saha, Sudeshna, Khan, Naazneen, Comi, Troy, Verhagen, Andrea, Sasmal, Aniruddha, Diaz, Sandra, Yu, Hai, Chen, Xi, Akey, Joshua M, Frank, Martin, Gagneux, Pascal, Varki, Ajit
Publicado 2022

Sialoglycan-binding patterns of bacterial AB(5) toxin B subunits correlate with host range and toxicity, indicating evolution independent of A subunits

por Khan, Naazneen, Sasmal, Aniruddha, Khedri, Zahra, Secrest, Patrick, Verhagen, Andrea, Srivastava, Saurabh, Varki, Nissi, Chen, Xi, Yu, Hai, Beddoe, Travis, Paton, Adrienne W., Paton, James C., Varki, Ajit
Publicado 2022

Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression

por Siddiqui, Shoib S, Vaill, Michael, Do, Raymond, Khan, Naazneen, Verhagen, Andrea L, Zhang, Wu, Lenz, Heinz‐Josef, Johnson‐Pais, Teresa L, Leach, Robin J, Fraser, Gary, Wang, Charles, Feng, Gen‐Sheng, Varki, Nissi, Varki, Ajit
Publicado 2020