Glucose inhibits glucagon secretion by decreasing [Ca(2+)](c) and by reducing the efficacy of Ca(2+) on exocytosis via somatostatin-dependent and independent mechanisms

por Singh, Bilal, Khattab, Firas, Gilon, Patrick
Publicado 2022

K(ATP) channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca(2+)](c) rise and an indirect inhibition mediated by somat...

por Singh, Bilal, Khattab, Firas, Chae, Heeyoung, Desmet, Lieven, Herrera, Pedro L., Gilon, Patrick
Publicado 2021

Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion

por Li, Min, Zhang, Ruifan, Ge, Qian, Yue, Lingzhi, Ma, Dan, Khattab, Firas, Xie, Wenhua, Cui, Yewei, Gilon, Patrick, Zhao, Xueya, Li, Xi, Cheng, Rui
Publicado 2023

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

por Chae, Heeyoung, Augustin, Robert, Gatineau, Eva, Mayoux, Eric, Bensellam, Mohammed, Antoine, Nancy, Khattab, Firas, Lai, Bao-Khanh, Brusa, Davide, Stierstorfer, Birgit, Klein, Holger, Singh, Bilal, Ruiz, Lucie, Pieper, Michael, Mark, Michael, Herrera, Pedro L., Gribble, Fiona M., Reimann, Frank, Wojtusciszyn, Anne, Broca, Christophe, Rita, Nano, Piemonti, Lorenzo, Gilon, Patrick
Publicado 2020