Antibody targeted CpG for the immunotherapy of solid tumors

por Epstein, Alan L, Jang, Julie, Hu, Peisheng, Khawli, Leslie A
Publicado 2015

Principles of N-Linked Glycosylation Variations of IgG-Based Therapeutics: Pharmacokinetic and Functional Considerations

por Boune, Souad, Hu, Peisheng, Epstein, Alan L., Khawli, Leslie A.
Publicado 2020

Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development

por Tibbitts, Jay, Canter, David, Graff, Ryan, Smith, Alison, Khawli, Leslie A.
Publicado 2015

Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development

por Lu, Yanmei, Khawli, Leslie A., Purushothama, Shobha, Theil, Frank-Peter, Partridge, Michael A.
Publicado 2016

Brain Disposition of Antibody-Based Therapeutics: Dogma, Approaches and Perspectives

por Kouhi, Aida, Pachipulusu, Vyshnavi, Kapenstein, Talya, Hu, Peisheng, Epstein, Alan L., Khawli, Leslie A.
Publicado 2021

Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins

por Smith, Alison, Manoli, Hugh, Jaw, Stacey, Frutoz, Kimberley, Epstein, Alan L., Khawli, Leslie A., Theil, Frank-Peter
Publicado 2016

Lym-1 Chimeric Antigen Receptor T Cells Exhibit Potent Anti-Tumor Effects against B-Cell Lymphoma

por Zheng, Long, Hu, Peisheng, Wolfe, Brandon, Gonsalves, Caryn, Ren, Luqing, Khawli, Leslie A., Kaslow, Harvey R., Epstein, Alan L.
Publicado 2017

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow

por Boswell, C. Andrew, Ferl, Gregory Z., Mundo, Eduardo E., Bumbaca, Daniela, Schweiger, Michelle G., Theil, Frank-Peter, Fielder, Paul J., Khawli, Leslie A.
Publicado 2011

Spatio-temporal biodistribution of (89)Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model

por Sta Maria, Naomi S., Khawli, Leslie A., Pachipulusu, Vyshnavi, Lin, Sharon W., Zheng, Long, Cohrs, Daniel, Liu, Xiaodan, Hu, Peisheng, Epstein, Alan L., Jacobs, Russell E.
Publicado 2021

Quantitative cumulative biodistribution of antibodies in mice: Effect of modulating binding affinity to the neonatal Fc receptor

por Yip, Victor, Palma, Enzo, Tesar, Devin B, Mundo, Eduardo E, Bumbaca, Daniela, Torres, Elizabeth K, Reyes, Noe A, Shen, Ben Q, Fielder, Paul J, Prabhu, Saileta, Khawli, Leslie A, Boswell, C Andrew
Publicado 2014

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

por Kamath, Amrita V, Yip, Victor, Gupta, Priyanka, Boswell, C Andrew, Bumbaca, Daniela, Haughney, Peter, Castro, Joni, Tsai, Siao Ping, Pacheco, Glenn, Ross, Sarajane, Yan, Minhong, Damico-Beyer, Lisa A, Khawli, Leslie, Shen, Ben-Quan
Publicado 2014

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer

por Boswell, C. Andrew, Yadav, Daniela Bumbaca, Mundo, Eduardo E., Yu, Shang-Fan, Lacap, Jennifer Arca, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ferl, Gregory Z., Zhang, Crystal, Ho, Jason, Ulufatu, Sheila, Khawli, Leslie A., Lin, Kedan
Publicado 2019