Predicting Risk of Hypertension Among Childhood Cancer Survivors: A Polygenic Score to the Rescue?

por Agrawal, Saaket, Khera, Amit V.
Publicado 2021

Single-cell transcriptomics: an emerging tool in the study of cardiometabolic disease

por Khera, Amit V, Mehta, Nehal N
Publicado 2014

Association of Acculturation and Cardiometabolic Disease Among Immigrants of South Asian Ancestry

por Kathiresan, Nikhil, Khera, Amit V., Patel, Aniruddh P.
Publicado 2023

The potential of polygenic scores to improve cost and efficiency of clinical trials

por Fahed, Akl C., Philippakis, Anthony A., Khera, Amit V.
Publicado 2022

Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease

por Emdin, Connor A., Klarin, Derek, Natarajan, Pradeep, Florez, Jose C., Kathiresan, Sekar, Khera, Amit V.
Publicado 2017

Race, socioeconomic deprivation, and hospitalization for COVID-19 in English participants of a national biobank

por Patel, Aniruddh P., Paranjpe, Manish D., Kathiresan, Nina P., Rivas, Manuel A., Khera, Amit V.
Publicado 2020

Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores

por Homburger, Julian R., Neben, Cynthia L., Mishne, Gilad, Zhou, Alicia Y., Kathiresan, Sekar, Khera, Amit V.
Publicado 2019

Genomic analysis of lean individuals with NAFLD identifies monogenic disorders in a prospective cohort study

por Zheng, Melanie, Huang, Daniel Q., Konkwo, Chigoziri, Agrawal, Saaket, Khera, Amit V., Loomba, Rohit, Vilarinho, Sílvia, Ajmera, Veeral
Publicado 2023

Polygenic risk for type 2 diabetes, lifestyle, metabolic health, and cardiovascular disease: a prospective UK Biobank study

por Yun, Jae-Seung, Jung, Sang-Hyuk, Shivakumar, Manu, Xiao, Brenda, Khera, Amit V., Won, Hong-Hee, Kim, Dokyoon
Publicado 2022

Silhouette images enable estimation of body fat distribution and associated cardiometabolic risk

por Klarqvist, Marcus D. R., Agrawal, Saaket, Diamant, Nathaniel, Ellinor, Patrick T., Philippakis, Anthony, Ng, Kenney, Batra, Puneet, Khera, Amit V.
Publicado 2022

Associations between polygenic risk of coronary artery disease and type 2 diabetes, lifestyle, and cardiovascular mortality: A prospective UK Biobank study

por Yun, Jae-Seung, Jung, Sang-Hyuk, Shivakumar, Manu, Xiao, Brenda, Khera, Amit V., Park, Woong-Yang, Won, Hong-Hee, Kim, Dokyoon
Publicado 2022

Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease

por Biddinger, Kiran J., Emdin, Connor A., Haas, Mary E., Wang, Minxian, Hindy, George, Ellinor, Patrick T., Kathiresan, Sekar, Khera, Amit V., Aragam, Krishna G.
Publicado 2022

Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies

por Kim, Min Seo, Kim, Won Jun, Khera, Amit V, Kim, Jong Yeob, Yon, Dong Keon, Lee, Seung Won, Shin, Jae Il, Won, Hong-Hee
Publicado 2021

Leveraging fine-mapping and multi-population training data to improve cross-population polygenic risk scores

por Weissbrod, Omer, Kanai, Masahiro, Shi, Huwenbo, Gazal, Steven, Peyrot, Wouter J., Khera, Amit V., Okada, Yukinori, Martin, Alicia R., Finucane, Hilary, Price, Alkes L.
Publicado 2022

Prediction performance and fairness heterogeneity in cardiovascular risk models

por Kartoun, Uri, Khurshid, Shaan, Kwon, Bum Chul, Patel, Aniruddh P., Batra, Puneet, Philippakis, Anthony, Khera, Amit V., Ellinor, Patrick T., Lubitz, Steven A., Ng, Kenney
Publicado 2022

Selection of 51 predictors from 13,782 candidate multimodal features using machine learning improves coronary artery disease prediction

por Agrawal, Saaket, Klarqvist, Marcus D.R., Emdin, Connor, Patel, Aniruddh P., Paranjpe, Manish D., Ellinor, Patrick T., Philippakis, Anthony, Ng, Kenney, Batra, Puneet, Khera, Amit V.
Publicado 2021

Estimated Yield of Screening for Heterozygous Familial Hypercholesterolemia With and Without Genetic Testing in US Adults

por Bellows, Brandon K., Khera, Amit V., Zhang, Yiyi, Ruiz‐Negrón, Natalia, Stoddard, Henry M., Wong, John B., Kazi, Dhruv S., de Ferranti, Sarah D., Moran, Andrew E.
Publicado 2022

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

por Khera, Amit V., Chaffin, Mark, Aragam, Krishna G., Haas, Mary E., Roselli, Carolina, Choi, Seung Hoan, Natarajan, Pradeep, Lander, Eric S., Lubitz, Steven A., Ellinor, Patrick T., Kathiresan, Sekar
Publicado 2018

Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI

por Georgi, Benjamin, Mielke, Johanna, Chaffin, Mark, Khera, Amit V., Gelis, Lian, Mundl, Hardi, van Giezen, J.J.J., Ellinor, Patrick, Kathiresan, Sekar, Ziegelbauer, Karl, Freitag, Daniel F.
Publicado 2019

Association of the Interaction Between Familial Hypercholesterolemia Variants and Adherence to a Healthy Lifestyle With Risk of Coronary Artery Disease

por Fahed, Akl C., Wang, Minxian, Patel, Aniruddh P., Ajufo, Ezimamaka, Maamari, Dimitri J., Aragam, Krishna G., Brockman, Deanna G., Vosburg, Trish, Ellinor, Patrick T., Ng, Kenney, Khera, Amit V.
Publicado 2022