Delivering two new treatments for malaria: a story of inventive partnerships

por Diap, Graciela, Olliaro, Piero, Kiechel, Jean-René
Publicado 2012

The story of artesunate–mefloquine (ASMQ), innovative partnerships in drug development: case study

por Wells, Susan, Diap, Graciela, Kiechel, Jean-René
Publicado 2013

Innovative public-private partnerships to maximize the delivery of anti-malarial medicines: lessons learned from the ASAQ Winthrop experience

por Bompart, François, Kiechel, Jean-René, Sebbag, Robert, Pecoul, Bernard
Publicado 2011

Population pharmacokinetics of mefloquine, administered as a fixed-dose combination of artesunate-mefloquine in Indian patients for the treatment of acute uncomplicated Plasmodium...

por Jullien, Vincent, Valecha, Neena, Srivastava, Bina, Sharma, Bhawna, Kiechel, Jean-René
Publicado 2014

Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

por Guidi, Monia, Mercier, Thomas, Aouri, Manel, Decosterd, Laurent A., Csajka, Chantal, Ogutu, Bernhards, Carn, Gwénaëlle, Kiechel, Jean-René
Publicado 2019

Fixed dose artesunate amodiaquine – a phase IIb, randomized comparative trial with non-fixed artesunate amodiaquine

por Ogutu, Bernhards, Juma, Elizabeth, Obonyo, Charles, Jullien, Vincent, Carn, Gwenaelle, Vaillant, Michel, Taylor, Walter Robert John, Kiechel, Jean-René
Publicado 2014

Therapeutic efficacy of fixed dose artesunate-mefloquine for the treatment of acute, uncomplicated Plasmodium falciparum malaria in Kampong Speu, Cambodia

por Leang, Rithea, Ros, Sakun, Duong, Socheat, Navaratnam, Visweswaran, Lim, Pharath, Ariey, Frédéric, Kiechel, Jean-René, Ménard, Didier, Taylor, Walter RJ
Publicado 2013

Access to Artemisinin-Combination Therapy (ACT) and other Anti-Malarials: National Policy and Markets in Sierra Leone

por Amuasi, John H., Diap, Graciela, Nguah, Samuel Blay, Karikari, Patrick, Boakye, Isaac, Jambai, Amara, Lahai, Wani Kumba, Louie, Karly S., Kiechel, Jean-Rene
Publicado 2012

Access to artesunate-amodiaquine, quinine and other anti-malarials: policy and markets in Burundi

por Amuasi, John H, Diap, Graciela, Blay-Nguah, Samuel, Boakye, Isaac, Karikari, Patrick E, Dismas, Baza, Karenzo, Jeanne, Nsabiyumva, Lievin, Louie, Karly S, Kiechel, Jean-René
Publicado 2011

Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers

por Navaratnam, Visweswaran, Ramanathan, Surash, Wahab, Mohd Suhaimi Ab., Siew Hua, Gan, Mansor, Sharif Mahsufi, Kiechel, Jean-René, Vaillant, Michel, Taylor, Walter R. J., Olliaro, Piero
Publicado 2009

The efficacy and safety of a new fixed-dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum

por Sirima, Sodiomon B, Tiono, Alfred B, Gansané, Adama, Diarra, Amidou, Ouédraogo, Amidou, Konaté, Amadou T, Kiechel, Jean René, Morgan, Caroline C, Olliaro, Piero L, Taylor, Walter RJ
Publicado 2009

Population pharmacokinetics of artesunate and amodiaquine in African children

por Stepniewska, Kasia, Taylor, Walter, Sirima, Sodiomon B, Ouedraogo, Esperance B, Ouedraogo, Alphonse, Gansané, Adama, Simpson, Julie A, Morgan, Caroline C, White, Nicholas J, Kiechel, Jean-René
Publicado 2009

The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership

por Lacaze, Catherine, Kauss, Tina, Kiechel, Jean-René, Caminiti, Antonella, Fawaz, Fawaz, Terrassin, Laurent, Cuart, Sylvie, Grislain, Luc, Navaratnam, Visweswaran, Ghezzoul, Bellabes, Gaudin, Karen, White, Nick J, Olliaro, Piero L, Millet, Pascal
Publicado 2011

Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate–amodiaquine fixed dose combination or artemether–lumefantrine in Liberia

por Otienoburu, Sabina Dahlström, Maïga-Ascofaré, Oumou, Schramm, Birgit, Jullien, Vincent, Jones, Joel J., Zolia, Yah M., Houzé, Pascal, Ashley, Elizabeth A., Kiechel, Jean-René, Guérin, Philippe J., Le Bras, Jacques, Houzé, Sandrine
Publicado 2016

Tolerability and safety of artesunate-amodiaquine and artemether-lumefantrine fixed dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria: two open-lab...

por Schramm, Birgit, Valeh, Parastou, Baudin, Elisabeth, Mazinda, Charles S, Smith, Richard, Pinoges, Loretxu, Sundaygar, Timothy, Zolia, Yah M, Jones, Joel J, Comte, Eric, Bruneel, Arnaud, Branger, Michel, Jullien, Vincent, Carn, Gwenaelle, Kiechel, Jean-René, Ashley, Elizabeth A, Guérin, Philippe J
Publicado 2013

Cardiovascular Concentration-Effect Relationships of Amodiaquine and its Metabolite Desethylamodiaquine: Clinical and Pre-clinical Studies

por Chan, Xin Hui S, Chotsiri, Palang, Capel, Rebecca A, Pike, James, Hanboonkunupakarn, Borimas, Lee, Sue J, Hanafiah, Maryam, Win, Yan Naung, Cremer, Maegan, Kiechel, Jean-René, Ogutu, Bernhards, Taylor, Walter RJ, Burton, Rebecca-Ann B, Tarning, Joel, White, Nicholas J
Publicado 2023

Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 5...

por Schramm, Birgit, Valeh, Parastou, Baudin, Elisabeth, Mazinda, Charles S, Smith, Richard, Pinoges, Loretxu, Dhorda, Mehul, Boum, Yap, Sundaygar, Timothy, Zolia, Yah M, Jones, Joel J, Comte, Eric, Houzé, Pascal, Jullien, Vincent, Carn, Gwenaelle, Kiechel, Jean-René, Ashley, Elizabeth A, Guérin, Philippe J
Publicado 2013

A Randomized Trial to Compare the Safety, Tolerability, and Effectiveness of 3 Antimalarial Regimens for the Prevention of Malaria in Nigerian Patients With Sickle Cell Disease

por Olaosebikan, Rasaq, Ernest, Kolade, Bojang, Kalifa, Mokuolu, Olugbenga, Rehman, Andrea M., Affara, Muna, Nwakanma, Davis, Kiechel, Jean-René, Ogunkunle, Taofik, Olagunju, Tope, Murtala, Rukayat, Omefe, Peter, Lambe, Tosin, Bello, Surajudeen, Ibrahim, Olayinka, Olorunsola, Benedict, Ojuawo, Ayotade, Greenwood, Brian, Milligan, Paul
Publicado 2015

Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing

por Ali, Ali Mohamed, Penny, Melissa A., Smith, Thomas A., Workman, Lesley, Sasi, Philip, Adjei, George O., Aweeka, Francesca, Kiechel, Jean-René, Jullien, Vincent, Rijken, Marcus J., McGready, Rose, Mwesigwa, Julia, Kristensen, Kim, Stepniewska, Kasia, Tarning, Joel, Barnes, Karen I., Denti, Paolo
Publicado 2018

The cardiovascular effects of amodiaquine and structurally related antimalarials: An individual patient data meta-analysis

por Chan, Xin Hui S., Haeusler, Ilsa L., Win, Yan Naung, Pike, James, Hanboonkunupakarn, Borimas, Hanafiah, Maryam, Lee, Sue J., Djimdé, Abdoulaye, Fanello, Caterina I., Kiechel, Jean-René, Lacerda, Marcus VG, Ogutu, Bernhards, Onyamboko, Marie A., Siqueira, André M., Ashley, Elizabeth A., Taylor, Walter RJ, White, Nicholas J.
Publicado 2021