Unmasking the U2AF homology motif family: a bona fide protein–protein interaction motif in disguise

por Loerch, Sarah, Kielkopf, Clara L.
Publicado 2016

Staufen1 dimerizes via a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay

por Gleghorn, Michael L., Gong, Chenguang, Kielkopf, Clara L., Maquat, Lynne E.
Publicado 2013

U2AF(65) adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs

por Jenkins, Jermaine L., Agrawal, Anant A., Gupta, Ankit, Green, Michael R., Kielkopf, Clara L.
Publicado 2013

A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation

por Warnasooriya, Chandani, Feeney, Callen F, Laird, Kholiswa M, Ermolenko, Dmitri N, Kielkopf, Clara L
Publicado 2020

An extended U2AF(65)–RNA-binding domain recognizes the 3′ splice site signal

por Agrawal, Anant A., Salsi, Enea, Chatrikhi, Rakesh, Henderson, Steven, Jenkins, Jermaine L., Green, Michael R., Ermolenko, Dmitri N., Kielkopf, Clara L.
Publicado 2016

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival

por Fei, Dennis Liang, Motowski, Hayley, Chatrikhi, Rakesh, Prasad, Sameer, Yu, Jovian, Gao, Shaojian, Kielkopf, Clara L., Bradley, Robert K., Varmus, Harold
Publicado 2016

Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM–ULM interaction

por Talkish, Jason, Igel, Haller, Hunter, Oarteze, Horner, Steven W., Jeffery, Nazish N., Leach, Justin R., Jenkins, Jermaine L., Kielkopf, Clara L., Ares, Manuel
Publicado 2019

Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal

por Glasser, Eliezra, Maji, Debanjana, Biancon, Giulia, Puthenpeedikakkal, Anees Mohammed Keedakkatt, Cavender, Chapin E, Tebaldi, Toma, Jenkins, Jermaine L, Mathews, David H, Halene, Stephanie, Kielkopf, Clara L
Publicado 2022

A UHM–ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

por Galardi, Justin W., Bela, Victoria N., Jeffery, Nazish, He, Xueyang, Glasser, Eliezra, Loerch, Sarah, Jenkins, Jermaine L., Pulvino, Mary J., Boutz, Paul L., Kielkopf, Clara L.
Publicado 2022

U2AF1 Mutations Alter Sequence Specificity of pre-mRNA Binding and Splicing

por Okeyo-Owuor, Theresa, White, Brian S., Chatrikhi, Rakesh, Mohan, Dipika R., Kim, Sanghyun, Griffith, Malachi, Ding, Li, Ketkar-Kulkarni, Shamika, Hundal, Jasreet, Laird, Kholiswa M., Kielkopf, Clara L., Ley, Timothy J., Walter, Matthew J., Graubert, Timothy A.
Publicado 2014