Utility of AlphaMissense predictions in Asparagine Synthetase deficiency variant classification

por Staklinski, Stephen J., Scheben, Armin, Siepel, Adam, Kilberg, Michael S.
Publicado 2023

A method for measurement of human asparagine synthetase (ASNS) activity and application to ASNS protein variants associated with ASNS deficiency

por Chang, Mario C, Staklinski, Stephen J, Merritt, Matthew E, Kilberg, Michael S
Publicado 2023

Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia

por Chiu, Martina, Taurino, Giuseppe, Bianchi, Massimiliano G., Kilberg, Michael S., Bussolati, Ovidio
Publicado 2020

The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes...

por Shan, Jixiu, Zhang, Fan, Sharkey, Jason, Tang, Tiffany A., Örd, Tönis, Kilberg, Michael S.
Publicado 2016

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex

por Thiaville, Michelle M., Dudenhausen, Elizabeth E., Awad, Keytam S., Gjymishka, Altin, Zhong, Can, Kilberg, Michael S.
Publicado 2008

Analysis of Enzyme Activity and Cellular Function for the N80S and S480F Asparagine Synthetase Variants Expressed in a Child with Asparagine Synthetase Deficiency

por Staklinski, Stephen J., Snanoudj, Sarah, Guerrot, Anne-Marie, Vanhulle, Catherine, Lecoquierre, François, Bekri, Soumeya, Kilberg, Michael S.
Publicado 2022

Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells

por Chang, Mario C., Staklinski, Stephen J., Malut, Vinay R., Pierre, Geraldine L., Kilberg, Michael S., Merritt, Matthew E.
Publicado 2023

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

por Teske, Brian F., Fusakio, Michael E., Zhou, Donghui, Shan, Jixiu, McClintick, Jeanette N., Kilberg, Michael S., Wek, Ronald C.
Publicado 2013

Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling

por Mukherjee, Amitava, Ahmed, Nayyar, Rose, Fateema T., Ahmad, Abraheem N., Javed, Tanveer A., Wen, Li, Bottino, Rita, Xiao, Xiangwei, Kilberg, Michael S., Husain, Sohail Z.
Publicado 2019

Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines

por Staklinski, Stephen J., Chang, Mario C., Ahrens‐Nicklas, Rebecca C., Kaur, Shagun, Stefanatos, Arianna K., Dudenhausen, Elizabeth E., Merritt, Matthew E., Kilberg, Michael S.
Publicado 2023

Genomic and proteomic analysis of transcription factor TFII-I reveals insight into the response to cellular stress

por Fan, Alex Xiucheng, Papadopoulos, Giorgio L., Hossain, Mir A., Lin, I.-Ju, Hu, Jianhong, Tang, Tommy Ming, Kilberg, Michael S., Renne, Rolf, Strouboulis, John, Bungert, Jörg
Publicado 2014

Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency

por Staklinski, Stephen J., Chang, Mario C., Yu, Fang, Collins Ruff, Kathleen, Franz, David N., Qian, Zhijian, Bloom, Linda B., Merritt, Matthew E., McKenna, Robert, Kilberg, Michael S.
Publicado 2022

Sequencing of Argonaute-bound microRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a

por Fields, Christopher J., Li, Lu, Hiers, Nicholas M., Li, Tianqi, Sheng, Peike, Huda, Taha, Shan, Jixiu, Gay, Lauren, Gu, Tongjun, Bian, Jiang, Kilberg, Michael S., Renne, Rolf, Xie, Mingyi
Publicado 2021

Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells

por Ferreira, Renan B., Wang, Mengxiong, Law, Mary E., Davis, Bradley J., Bartley, Ashton N., Higgins, Paul J., Kilberg, Michael S., Santostefano, Katherine E., Terada, Naohiro, Heldermon, Coy D., Castellano, Ronald K., Law, Brian K.
Publicado 2017

Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress

por Yuniati, Laurensia, van der Meer, Laurens T., Tijchon, Esther, van Ingen Schenau, Dorette, van Emst, Liesbeth, Levers, Marloes, Palit, Sander A.L., Rodenbach, Caroline, Poelmans, Geert, Hoogerbrugge, Peter M., Shan, Jixiu, Kilberg, Michael S., Scheijen, Blanca, van Leeuwen, Frank N.
Publicado 2015

PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

por Farabaugh, Kenneth T, Krokowski, Dawid, Guan, Bo-Jhih, Gao, Zhaofeng, Gao, Xing-Huang, Wu, Jing, Jobava, Raul, Ray, Greeshma, de Jesus, Tristan J, Bianchi, Massimiliano G, Chukwurah, Evelyn, Bussolati, Ovidio, Kilberg, Michael, Buchner, David A, Sen, Ganes C, Cotton, Calvin, McDonald, Christine, Longworth, Michelle, Ramakrishnan, Parameswaran, Hatzoglou, Maria
Publicado 2020

Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability

por Chiu, Martina, Toscani, Denise, Marchica, Valentina, Taurino, Giuseppe, Costa, Federica, Bianchi, Massimiliano G., Andreoli, Roberta, Franceschi, Valentina, Storti, Paola, Burroughs-Garcia, Jessica, Eufemiese, Rosa Alba, Dalla Palma, Benedetta, Campanini, Nicoletta, Martella, Eugenia, Mancini, Cristina, Shan, Jixiu, Kilberg, Michael S., D’Amico, Giovanna, Dander, Erica, Agnelli, Luca, Pruneri, Giancarlo, Donofrio, Gaetano, Bussolati, Ovidio, Giuliani, Nicola
Publicado 2020