Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway

por Lee, Jae Seong, Kallehauge, Thomas Beuchert, Pedersen, Lasse Ebdrup, Kildegaard, Helene Faustrup
Publicado 2015

Risk of adverse events after covid-19 in Danish children and adolescents and effectiveness of BNT162b2 in adolescents: cohort study

por Kildegaard, Helene, Lund, Lars Christian, Højlund, Mikkel, Stensballe, Lone Graff, Pottegård, Anton
Publicado 2022

A novel low-parameter computational model to aid in-silico glycoengineering

por Spahn, Philipp N, Hansen, Anders H, Hansen, Henning G, Arnsdorf, Johnny, Kildegaard, Helene F, Lewis, Nathan E
Publicado 2015

Multi‐omic profiling ­of EPO‐producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

por Ley, Daniel, Seresht, Ali Kazemi, Engmark, Mikael, Magdenoska, Olivera, Nielsen, Kristian Fog, Kildegaard, Helene Faustrup, Andersen, Mikael Rørdam
Publicado 2015

Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data

por Lund, Anne Mathilde, Kaas, Christian Schrøder, Brandl, Julian, Pedersen, Lasse Ebdrup, Kildegaard, Helene Faustrup, Kristensen, Claus, Andersen, Mikael Rørdam
Publicado 2017

PR interval prolongation and 1-year mortality among emergency department patients: a multicentre transnational cohort study

por Vad, Rune, Larsen, Tobias Malte, Kildegaard, Helene, Brabrand, Mikkel, Lundager Forberg, Jakob, Ekelund, Ulf, Pottegard, Anton, Lassen, Annmarie Touborg
Publicado 2021

Accelerating Genome Editing in CHO Cells Using CRISPR Cas9 and CRISPy, a Web-Based Target Finding Tool

por Ronda, Carlotta, Pedersen, Lasse Ebdrup, Hansen, Henning Gram, Kallehauge, Thomas Beuchert, Betenbaugh, Michael J, Nielsen, Alex Toftgaard, Kildegaard, Helene Faustrup
Publicado 2014

A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

por Schmieder, Valerie, Novak, Neža, Dhiman, Heena, Nguyen, Ly Ngoc, Serafimova, Evgenija, Klanert, Gerald, Baumann, Martina, Kildegaard, Helene Faustrup, Borth, Nicole
Publicado 2021

A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

por Lund, Anne Mathilde, Kildegaard, Helene Faustrup, Petersen, Maja Borup Kjær, Rank, Julie, Hansen, Bjarne Gram, Andersen, Mikael Rørdam, Mortensen, Uffe Hasbro
Publicado 2014

Modular 5′-UTR hexamers for context-independent tuning of protein expression in eukaryotes

por Petersen, Søren D, Zhang, Jie, Lee, Jae S, Jakočiūnas, Tadas, Grav, Lise M, Kildegaard, Helene F, Keasling, Jay D, Jensen, Michael K
Publicado 2018

Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion

por Kallehauge, Thomas Beuchert, Li, Shangzhong, Pedersen, Lasse Ebdrup, Ha, Tae Kwang, Ley, Daniel, Andersen, Mikael Rørdam, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E.
Publicado 2017

Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

por Hansen, Henning Gram, Nilsson, Claes Nymand, Lund, Anne Mathilde, Kol, Stefan, Grav, Lise Marie, Lundqvist, Magnus, Rockberg, Johan, Lee, Gyun Min, Andersen, Mikael Rørdam, Kildegaard, Helene Faustrup
Publicado 2015

An optimized genome-wide, virus-free CRISPR screen for mammalian cells

por Xiong, Kai, la Cour Karottki, Karen Julie, Hefzi, Hooman, Li, Songyuan, Grav, Lise Marie, Li, Shangzhong, Spahn, Philipp, Lee, Jae Seong, Ventina, Ildze, Lee, Gyun Min, Lewis, Nathan E., Kildegaard, Helene Faustrup, Pedersen, Lasse Ebdrup
Publicado 2021

An optimized genome-wide, virus-free CRISPR screen for mammalian cells

por Xiong, Kai, Karottki, Karen Julie la Cour, Hefzi, Hooman, Li, Songyuan, Grav, Lise Marie, Li, Shangzhong, Spahn, Philipp, Lee, Jae Seong, Ventina, Ildze, Lee, Gyun Min, Lewis, Nathan E., Kildegaard, Helene Faustrup, Pedersen, Lasse Ebdrup
Publicado 2021

Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

por Gutierrez, Jahir M., Feizi, Amir, Li, Shangzhong, Kallehauge, Thomas B., Hefzi, Hooman, Grav, Lise M., Ley, Daniel, Baycin Hizal, Deniz, Betenbaugh, Michael J., Voldborg, Bjorn, Faustrup Kildegaard, Helene, Min Lee, Gyun, Palsson, Bernhard O., Nielsen, Jens, Lewis, Nathan E.
Publicado 2020

A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells

por Shamie, Isaac, Duttke, Sascha H, Karottki, Karen J la Cour, Han, Claudia Z, Hansen, Anders H, Hefzi, Hooman, Xiong, Kai, Li, Shangzhong, Roth, Samuel J, Tao, Jenhan, Lee, Gyun Min, Glass, Christopher K, Kildegaard, Helene Faustrup, Benner, Christopher, Lewis, Nathan E
Publicado 2021

Multiplex secretome engineering enhances recombinant protein production and purity

por Kol, Stefan, Ley, Daniel, Wulff, Tune, Decker, Marianne, Arnsdorf, Johnny, Schoffelen, Sanne, Hansen, Anders Holmgaard, Jensen, Tanja Lyholm, Gutierrez, Jahir M., Chiang, Austin W. T., Masson, Helen O., Palsson, Bernhard O., Voldborg, Bjørn G., Pedersen, Lasse Ebdrup, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E.
Publicado 2020