Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells

por Mehta, Ishita S, Eskiw, Christopher H, Arican, Halime D, Kill, Ian R, Bridger, Joanna M
Publicado 2011

Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson–Gilford progeria syndrome fibroblasts

por Bikkul, Mehmet U., Clements, Craig S., Godwin, Lauren S., Goldberg, Martin W., Kill, Ian R., Bridger, Joanna M.
Publicado 2018

Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways

por Clements, Craig S., Bikkul, Mehmet U., Ofosu, Wendy, Eskiw, Christopher, Tree, David, Makarov, Evgeny, Kill, Ian R., Bridger, Joanna M.
Publicado 2019

Interphase Chromosomes in Replicative Senescence: Chromosome Positioning as a Senescence Biomarker and the Lack of Nuclear Motor-Driven Chromosome Repositioning in Senescent Cells

por Mehta, Ishita S., Riyahi, Kumars, Pereira, Rita Torres, Meaburn, Karen J., Figgitt, Martin, Kill, Ian R., Eskiw, Christopher H., Bridger, Joanna M.
Publicado 2021

Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson‐Gilford progeria syndrome fibroblasts, ex...

por Bikkul, Mehmet U., Faragher, Richard G. A., Worthington, Gemma, Meinke, Peter, Kerr, Alastair R. W., Sammy, Aakila, Riyahi, Kumars, Horton, Daniel, Schirmer, Eric C., Hubank, Michael, Kill, Ian R., Anderson, Rhona M., Slijepcevic, Predrag, Makarov, Evgeny, Bridger, Joanna M.
Publicado 2019