DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors

por Laranjeira, Angelo B. A., Hollingshead, Melinda G., Nguyen, Dat, Kinders, Robert J., Doroshow, James H., Yang, Sherry X.
Publicado 2023

Advances in using PARP inhibitors to treat cancer

por Kummar, Shivaani, Chen, Alice, Parchment, Ralph E, Kinders, Robert J, Ji, Jay, Tomaszewski, Joseph E, Doroshow, James H
Publicado 2012

Modeling Pharmacodynamic Response to the Poly(ADP-Ribose) Polymerase Inhibitor ABT-888 in Human Peripheral Blood Mononuclear Cells

por Ji, Jiuping, Kinders, Robert J., Zhang, Yiping, Rubinstein, Larry, Kummar, Shivaani, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Publicado 2011

TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models

por Yang, Sherry X., Hollingshead, Melinda, Rubinstein, Larry, Nguyen, Dat, Larenjeira, Angelo B. A., Kinders, Robert J., Difilippantonio, Michael, Doroshow, James H.
Publicado 2021

Development of a quantitative pharmacodynamic assay for apoptosis in fixed tumor tissue and its application in distinguishing cytotoxic drug—induced DNA double strand breaks from D...

por Dull, Angie B., Wilsker, Deborah, Hollingshead, Melinda, Mazcko, Christina, Annunziata, Christina M., LeBlanc, Amy K., Doroshow, James H., Kinders, Robert J., Parchment, Ralph E.
Publicado 2018

Antibody-independent capture of circulating tumor cells of non-epithelial origin with the ApoStream(®) system

por Balasubramanian, Priya, Kinders, Robert J., Kummar, Shivaani, Gupta, Vishal, Hasegawa, David, Menachery, Anoop, Lawrence, Scott M., Wang, Lihua, Ferry-Galow, Katherine, Davis, Darren, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Publicado 2017

Development and Validation of an Immunoassay for Quantification of Topoisomerase I in Solid Tumor Tissues

por Pfister, Thomas D., Hollingshead, Melinda, Kinders, Robert J., Zhang, Yiping, Evrard, Yvonne A., Ji, Jiuping, Khin, Sonny A., Borgel, Suzanne, Stotler, Howard, Carter, John, Divelbiss, Raymond, Kummar, Shivaani, Pommier, Yves, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Publicado 2012

Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells

por Navas, Tony, Pfister, Thomas D., Colantonio, Simona, Aziz, Amina, Dieckman, Lynda, Saul, Richard G., Kaczmarczyk, Jan, Borgel, Suzanne, Alcoser, Sergio Y., Hollingshead, Melinda G., Lee, Young H., Bottaro, Donald P., Hiltke, Tara, Whiteley, Gordon, Takebe, Naoko, Kinders, Robert J., Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Publicado 2018

Intravenous 5-fluoro-2′-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced solid tumors...

por Coyne, Geraldine O.’Sullivan, Wang, Lihua, Zlott, Jennifer, Juwara, Lamin, Covey, Joseph M., Beumer, Jan H., Cristea, Mihaela C., Newman, Edward M., Koehler, Stephen, Nieva, Jorge J., Garcia, Agustin A., Gandara, David R., Miller, Brandon, Khin, Sonny, Miller, Sarah B., Steinberg, Seth M., Rubinstein, Larry, Parchment, Ralph E., Kinders, Robert J., Piekarz, Richard L., Kummar, Shivaani, Chen, Alice P., Doroshow, James H.
Publicado 2020

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas

por Coyne, Geraldine O'Sullivan, Kummar, Shivaani, Meehan, Robert S., Do, Khanh, Collins, Jerry M., Anderson, Larry, Ishii, Kazusa, Takebe, Naoko, Zlott, Jennifer, Juwara, Lamin, Piekarz, Richard, Streicher, Howard, Sharon, Elad, Rubinstein, Larry, Voth, Andrea Regier, Lozier, Jay, Dull, Angie B., Wilsker, Deborah, Hinoue, Toshinori, Laird, Peter W., Ferry-Galow, Katherine V., Kinders, Robert J., Parchment, Ralph E., Doroshow, James H., Chen, Alice P.
Publicado 2020

Interferon-gamma is quintessential for NOS2 and COX2 expression in ER(-) breast tumors that lead to poor outcome

por Cheng, Robert Y. S., Ridnour, Lisa A., Wink, Adelaide L., Gonzalez, Ana L., Femino, Elise L., Rittscher, Helene, Somasundaram, Veena, Heinz, William F., Coutinho, Leandro, Rangel, M. Cristina, Edmondson, Elijah F., Butcher, Donna, Kinders, Robert J., Li, Xiaoxian, Wong, Stephen T. C., McVicar, Daniel W., Anderson, Stephen K., Pore, Milind, Hewitt, Stephen M., Billiar, Timothy R., Glynn, Sharon A., Chang, Jenny C., Lockett, Stephen J., Ambs, Stefan, Wink, David A.
Publicado 2023

Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density

por Somasundaram, Veena, Ridnour, Lisa A., Cheng, Robert YS., Walke, Abigail J., Kedei, Noemi, Bhattacharyya, Dibyangana D., Wink, Adelaide L., Edmondson, Elijah F., Butcher, Donna, Warner, Andrew C., Dorsey, Tiffany H., Scheiblin, David A., Heinz, William, Bryant, Richard J., Kinders, Robert J., Lipkowitz, Stanley, Wong, Stephen TC., Pore, Milind, Hewitt, Stephen M., McVicar, Daniel W., Anderson, Stephen K., Chang, Jenny, Glynn, Sharon A., Ambs, Stefan, Lockett, Stephen J., Wink, David A.
Publicado 2022