Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia

por Sive, J I, Basilico, S, Hannah, R, Kinston, S J, Calero-Nieto, F J, Göttgens, B
Publicado 2016

Constrained transcription factor spacing is prevalent and important for transcriptional control of mouse blood cells

por Ng, Felicia SL, Schütte, Judith, Ruau, David, Diamanti, Evangelia, Hannah, Rebecca, Kinston, Sarah J., Göttgens, Berthold
Publicado 2014

Interactions between lineage‐associated transcription factors govern haematopoietic progenitor states

por Kucinski, Iwo, Wilson, Nicola K, Hannah, Rebecca, Kinston, Sarah J, Cauchy, Pierre, Lenaerts, Aurelie, Grosschedl, Rudolf, Göttgens, Berthold
Publicado 2020

ConBind: motif-aware cross-species alignment for the identification of functional transcription factor binding sites

por Lelieveld, Stefan H., Schütte, Judith, Dijkstra, Maurits J.J., Bawono, Punto, Kinston, Sarah J., Göttgens, Berthold, Heringa, Jaap, Bonzanni, Nicola
Publicado 2016

Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia

por Oram, S H, Thoms, J, Sive, J I, Calero-Nieto, F J, Kinston, S J, Schütte, J, Knezevic, K, Lock, R B, Pimanda, J E, Göttgens, B
Publicado 2013

Mapping and Functional Characterisation of a CTCF-Dependent Insulator Element at the 3′ Border of the Murine Scl Transcriptional Domain

por Follows, George A., Ferreira, Rita, Janes, Mary E., Spensberger, Dominik, Cambuli, Francesco, Chaney, Amy F., Kinston, Sarah J., Landry, Josette R., Green, Anthony R., Göttgens, Berthold
Publicado 2012

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

por Basilico, Silvia, Wang, Xiaonan, Kennedy, Alison, Tzelepis, Konstantinos, Giotopoulos, George, Kinston, Sarah J., Quiros, Pedro M., Wong, Kim, Adams, David J., Carnevalli, Larissa S., Huntly, Brian J. P., Vassiliou, George S., Calero-Nieto, Fernando J., Göttgens, Berthold
Publicado 2020

An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

por Schütte, Judith, Wang, Huange, Antoniou, Stella, Jarratt, Andrew, Wilson, Nicola K, Riepsaame, Joey, Calero-Nieto, Fernando J, Moignard, Victoria, Basilico, Silvia, Kinston, Sarah J, Hannah, Rebecca L, Chan, Mun Chiang, Nürnberg, Sylvia T, Ouwehand, Willem H, Bonzanni, Nicola, de Bruijn, Marella FTR, Göttgens, Berthold
Publicado 2016

Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner

por Wang, Meng, Brandt, Laura T.L., Wang, Xiaonan, Russell, Holly, Mitchell, Emily, Kamimae-Lanning, Ashley N., Brown, Jill M., Dingler, Felix A., Garaycoechea, Juan I., Isobe, Tomoya, Kinston, Sarah J., Gu, Muxin, Vassiliou, George S., Wilson, Nicola K., Göttgens, Berthold, Patel, Ketan J.
Publicado 2023

Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice

por Lewis, Jo E., Woodward, Orla RM., Nuzzaci, Danaé, Smith, Christopher A., Adriaenssens, Alice E., Billing, Lawrence, Brighton, Cheryl, Phillips, Benjamin U., Tadross, John A., Kinston, Sarah J., Ciabatti, Ernesto, Göttgens, Berthold, Tripodi, Marco, Hornigold, David, Baker, David, Gribble, Fiona M., Reimann, Frank
Publicado 2022

STAT1 is essential for HSC function and maintains MHCII(hi) stem cells that resist myeloablation and neoplastic expansion

por Li, Juan, Williams, Matthew J., Park, Hyun Jung, Bastos, Hugo P., Wang, Xiaonan, Prins, Daniel, Wilson, Nicola K., Johnson, Carys, Sham, Kendig, Wantoch, Michelle, Watcham, Sam, Kinston, Sarah J., Pask, Dean C., Hamilton, Tina L., Sneade, Rachel, Waller, Amie K., Ghevaert, Cedric, Vassiliou, George S., Laurenti, Elisa, Kent, David G., Göttgens, Berthold, Green, Anthony R.
Publicado 2022

Yolk sac cell atlas reveals multiorgan functions during human early development

por Goh, Issac, Botting, Rachel A., Rose, Antony, Webb, Simone, Engelbert, Justin, Gitton, Yorick, Stephenson, Emily, Londoño, Mariana Quiroga, Mather, Michael, Mende, Nicole, Imaz-Rosshandler, Ivan, Yang, Lu, Horsfall, Dave, Basurto-Lozada, Daniela, Chipampe, Nana-Jane, Rook, Victoria, Lee, Jimmy Tsz Hang, Ton, Mai-Linh, Keitley, Daniel, Mazin, Pavel, Vijayabaskar, M.S., Hannah, Rebecca, Gambardella, Laure, Green, Kile, Ballereau, Stephane, Inoue, Megumi, Tuck, Elizabeth, Lorenzi, Valentina, Kwakwa, Kwasi, Alsinet, Clara, Olabi, Bayanne, Miah, Mohi, Admane, Chloe, Popescu, Dorin-Mirel, Acres, Meghan, Dixon, David, Ness, Thomas, Coulthard, Rowen, Lisgo, Steven, Henderson, Deborah J, Dann, Emma, Suo, Chenqu, Kinston, Sarah J., Park, Jong-eun, Polanski, Krzysztof, Marioni, John, van Dongen, Stijn, Meyer, Kerstin B., de Bruijn, Marella, Palis, James, Behjati, Sam, Laurenti, Elisa, Wilson, Nicola K., Vento-Tormo, Roser, Chédotal, Alain, Bayraktar, Omer, Roberts, Irene, Jardine, Laura, Göttgens, Berthold, Teichmann, Sarah A., Haniffa, Muzlifah
Publicado 2023