A simulation model of heterochromatin formation at submolecular detail

por Williams, Michael R., Xiaokang, Yan, Hathaway, Nathaniel A., Kireev, Dmitri
Publicado 2022

Relationship between lysine methyltransferase levels and heterochromatin gene repression in living cells and in silico

por Yan, Xiaokang, Williams, Michael R, Barboza Castillo, Ameriks D, Kireev, Dmitri, Hathaway, Nathaniel A
Publicado 2023

Machine Learning-driven Fragment-based Discovery of CIB1-directed Anti-Tumor Agents by FRASE-bot

por An, Yi, Glavatskikh, Marta, Lim, Jiwoong, Wang, Xiaowen, Norris-Drouin, Jacqueline, Hardy, P. Brian, Leisner, Tina M., Pearce, Kenneth H., Kireev, Dmitri
Publicado 2023

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

por Hutti, Jessica E., Porter, Melissa A., Cheely, Adam W., Cantley, Lewis C., Wang, Xiaodong, Kireev, Dmitri, Baldwin, Albert S., Janzen, William P.
Publicado 2012

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

por Baughman, Brandi M., Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A., Jessen, Henning J., Pearce, Kenneth H., Frye, Stephen V., Shears, Stephen B.
Publicado 2016

Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

por Baughman, Brandi M., Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A., Jessen, Henning J., Pearce, Kenneth H., Frye, Stephen V., Shears, Stephen B.
Publicado 2017

Discovery of selective activators of PRC2 mutant EED-I363M

por Suh, Junghyun L., Barnash, Kimberly D., Abramyan, Tigran M., Li, Fengling, The, Juliana, Engelberg, Isabelle A., Vedadi, Masoud, Brown, Peter J., Kireev, Dmitri B., Arrowsmith, Cheryl H., James, Lindsey I., Frye, Stephen V.
Publicado 2019

MERTK activation drives osimertinib resistance in EGFR-mutant non–small cell lung cancer

por Yan, Dan, Huelse, Justus M., Kireev, Dmitri, Tan, Zikang, Chen, Luxiao, Goyal, Subir, Wang, Xiaodong, Frye, Stephen V., Behera, Madhusmita, Schneider, Frank, Ramalingam, Suresh S., Owonikoko, Taofeek, Earp, H. Shelton, DeRyckere, Deborah, Graham, Douglas K.
Publicado 2022

Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins

por Rectenwald, Justin M., Guduru, Shiva Krishna Reddy, Dang, Zhao, Collins, Leonard B., Liao, Yi-En, Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Kaufmann, Kyle W., Hammond, Scott M., Kireev, Dmitri B., Frye, Stephen V., Pearce, Kenneth H.
Publicado 2020

Multivalent DNA and nucleosome acidic patch interactions specify VRK1 mitotic localization and activity

por Budziszewski, Gabrielle R, Zhao, Yani, Spangler, Cathy J, Kedziora, Katarzyna M, Williams, Michael R, Azzam, Dalal N, Skrajna, Aleksandra, Koyama, Yuka, Cesmat, Andrew P, Simmons, Holly C, Arteaga, Eyla C, Strauss, Joshua D, Kireev, Dmitri, McGinty, Robert K
Publicado 2022

UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor

por Zhang, Weihe, DeRyckere, Deborah, Hunter, Debra, Liu, Jing, Stashko, Michael A., Minson, Katherine A., Cummings, Christopher T., Lee, Minjung, Glaros, Trevor G., Newton, Dianne L., Sather, Susan, Zhang, Dehui, Kireev, Dmitri, Janzen, William P., Earp, H. Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Publicado 2014

Discovery of a chemical probe for the L3MBTL3 methyl-lysine reader domain

por James, Lindsey I., Barsyte-Lovejoy, Dalia, Zhong, Nan, Krichevsky, Liubov, Korboukh, Victoria K., Herold, Martin J., MacNevin, Christopher J., Norris, Jacqueline L., Sagum, Cari A., Tempel, Wolfram, Marcon, Edyta, Guo, Hongbo, Gao, Cen, Huang, Xi-Ping, Duan, Shili, Emili, Andrew, Greenblatt, Jack F., Kireev, Dmitri B., Jin, Jian, Janzen, William P., Brown, Peter J., Bedford, Mark T., Arrowsmith, Cheryl H., Frye, Stephen V.
Publicado 2013

Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology

por Potjewyd, Frances M., Annor‐Gyamfi, Joel K., Aubé, Jeffrey, Chu, Shaoyou, Conlon, Ivie L., Frankowski, Kevin J., Guduru, Shiva K. R., Hardy, Brian P., Hopkins, Megan D., Kinoshita, Chizuru, Kireev, Dmitri B., Mason, Emily R., Moerk, Charles T., Nwogbo, Felix, Pearce, Kenneth H., Richardson, Timothy I., Rogers, David A., Soni, Disha M., Stashko, Michael, Wang, Xiaodong, Wells, Carrow, Willson, Timothy M., Frye, Stephen V., Young, Jessica E., Axtman, Alison D.
Publicado 2022

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

por Potjewyd, Frances M., Annor‐Gyamfi, Joel K., Aubé, Jeffrey, Chu, Shaoyou, Conlon, Ivie L., Frankowski, Kevin J., Guduru, Shiva K. R., Hardy, Brian P., Hopkins, Megan D., Kinoshita, Chizuru, Kireev, Dmitri B., Mason, Emily R., Moerk, Charles T., Nwogbo, Felix, Pearce, Kenneth H., Richardson, Timothy I., Rogers, David A., Soni, Disha M., Stashko, Michael, Wang, Xiaodong, Wells, Carrow, Willson, Timothy M., Frye, Stephen V., Young, Jessica E., Axtman, Alison D.
Publicado 2022

Reprogramming CBX8-PRC1 function with a positive allosteric modulator

por Suh, Junghyun L., Bsteh, Daniel, Hart, Bryce, Si, Yibo, Weaver, Tyler M., Pribitzer, Carina, Lau, Roy, Soni, Shivani, Ogana, Heather, Rectenwald, Justin M., Norris, Jacqueline L., Cholensky, Stephanie H., Sagum, Cari, Umana, Jessica D., Li, Dongxu, Hardy, Brian, Bedford, Mark T., Mumenthaler, Shannon M., Lenz, Heinz-Josef, Kim, Yong-Mi, Wang, Gang Greg, Pearce, Ken H., James, Lindsey I., Kireev, Dmitri B., Musselman, Catherine A., Frye, Stephen V., Bell, Oliver
Publicado 2022