Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease

por Sanchez-Guajardo, Vanesa, Febbraro, Fabia, Kirik, Deniz, Romero-Ramos, Marina
Publicado 2010

Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue

por Soylu-Kucharz, Rana, Adlesic, Natalie, Baldo, Barbara, Kirik, Deniz, Petersén, Åsa
Publicado 2015

Preserved Function of Afferent Parvalbumin-Positive Perisomatic Inhibitory Synapses of Dentate Granule Cells in Rapidly Kindled Mice

por Hansen, Marita G., Ledri, Litsa N., Kirik, Deniz, Kokaia, Merab, Ledri, Marco
Publicado 2018

Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): a new animal model of relevance to schizophrenia

por Petty, Alice, Cui, Xiaoying, Tesiram, Yasvir, Kirik, Deniz, Howes, Oliver, Eyles, Darryl
Publicado 2019

Effects of mutant huntingtin inactivation on Huntington disease‐related behaviours in the BACHD mouse model

por Cheong, Rachel Y., Baldo, Barbara, Sajjad, Muhammad U., Kirik, Deniz, Petersén, Åsa
Publicado 2021

The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson’s disease

por Grealish, Shane, Jönsson, Marie E., Li, Meng, Kirik, Deniz, Björklund, Anders, Thompson, Lachlan H.
Publicado 2010

Characterization of Cognitive Deficits in Rats Overexpressing Human Alpha-Synuclein in the Ventral Tegmental Area and Medial Septum Using Recombinant Adeno-Associated Viral Vectors

por Hall, Hélène, Jewett, Michael, Landeck, Natalie, Nilsson, Nathalie, Schagerlöf, Ulrika, Leanza, Giampiero, Kirik, Deniz
Publicado 2013

Generation of human-induced pluripotent-stem-cell-derived cortical neurons for high-throughput imaging of neurite morphology and neuron maturation

por Wali, Gautam, Li, Yan, Abu-Bonsrah, Dad, Kirik, Deniz, Parish, Clare L., Sue, Carolyn M.
Publicado 2023

Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease

por Cederfjäll, Erik, Nilsson, Nathalie, Sahin, Gurdal, Chu, Yaping, Nikitidou, Elisabeth, Björklund, Tomas, Kordower, Jeffrey H., Kirik, Deniz
Publicado 2013

Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease

por Sahin, Gurdal, Thompson, Lachlan H., Lavisse, Sonia, Ozgur, Merve, Rbah-Vidal, Latifa, Dollé, Frédéric, Hantraye, Philippe, Kirik, Deniz
Publicado 2014

Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity

por Kuzdas-Wood, Daniela, Fellner, Lisa, Premstaller, Melanie, Borm, Carlijn, Bloem, Bastiaan, Kirik, Deniz, Wenning, Gregor K., Stefanova, Nadia
Publicado 2015

A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein

por Landeck, Natalie, Hall, Hélène, Ardah, Mustafa T., Majbour, Nour K., El-Agnaf, Omar M. A., Halliday, Glenda, Kirik, Deniz
Publicado 2016

Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome

por Petty, Alice, Cui, Xiaoying, Ali, Asad, Du, Zilong, Srivastav, Sunil, Kesby, James P., Kirik, Deniz, Howes, Oliver, Eyles, Darryl
Publicado 2021

Nuclease-dead S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson’s disease

por Sastre, Danuta, Zafar, Faria, Torres, C. Alejandra Morato, Piper, Desiree, Kirik, Deniz, Sanders, Laurie H., Qi, Stanley, Schüle, Birgitt
Publicado 2023

Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease

por Sastre, Danuta, Zafar, Faria, Torres, C. Alejandra Morato, Piper, Desiree, Kirik, Deniz, Sanders, Laurie H., Qi, L. Stanley, Schüle, Birgitt
Publicado 2023

Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks

por Marciano, Sabina, Ionescu, Tudor M., Saw, Ran Sing, Cheong, Rachel Y., Kirik, Deniz, Maurer, Andreas, Pichler, Bernd J., Herfert, Kristina
Publicado 2022

Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

por Mandel, Ronald J., Marmion, David J., Kirik, Deniz, Chu, Yaping, Heindel, Clifford, McCown, Thomas, Gray, Steven J., Kordower, Jeffrey H.
Publicado 2017

Volumetric Analysis of the Hypothalamus in Huntington Disease Using 3T MRI: The IMAGE-HD Study

por Gabery, Sanaz, Georgiou-Karistianis, Nellie, Lundh, Sofia Hult, Cheong, Rachel Y., Churchyard, Andrew, Chua, Phyllis, Stout, Julie C., Egan, Gary F., Kirik, Deniz, Petersén, Åsa
Publicado 2015

Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay

por Baldo, Barbara, Sajjad, Muhammad Umar, Cheong, Rachel Y., Bigarreau, Julie, Vijayvargia, Ravi, McLean, Catriona, Perrier, Anselme L., Seong, Ihn Sik, Halliday, Glenda, Petersén, Åsa, Kirik, Deniz
Publicado 2018

Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation

por Reimer, Lasse, Gram, Hjalte, Jensen, Nanna Møller, Betzer, Cristine, Yang, Li, Jin, Lorrain, Shi, Min, Boudeffa, Driss, Fusco, Giuliana, De Simone, Alfonso, Kirik, Deniz, Lashuel, Hilal A, Zhang, Jing, Jensen, Poul Henning
Publicado 2022