Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system

por Mitchell, Jane A, Kirkby, Nicholas S
Publicado 2018

Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy

por Hoefer, Thomas, Armstrong, Paul C., Finsterbusch, Michaela, Chan, Melissa V., Kirkby, Nicholas S., Warner, Timothy D.
Publicado 2015

Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells

por Ahmetaj-Shala, Blerina, Vaja, Ricky, Atanur, Santosh S., George, Peter M., Kirkby, Nicholas S., Mitchell, Jane A.
Publicado 2020

Thrombosis Is Reduced by Inhibition of COX-1, but Unaffected by Inhibition of COX-2, in an Acute Model of Platelet Activation in the Mouse

por Armstrong, Paul C., Kirkby, Nicholas S., Zain, Zetty N., Emerson, Michael, Mitchell, Jane A., Warner, Timothy D.
Publicado 2011

Quantitative 3-Dimensional Imaging of Murine Neointimal and Atherosclerotic Lesions by Optical Projection Tomography

por Kirkby, Nicholas S., Low, Lucinda, Seckl, Jonathan R., Walker, Brian R., Webb, David J., Hadoke, Patrick W. F.
Publicado 2011

Differential role of pannexin-1/ATP/P2X(7) axis in IL-1β release by human monocytes

por Parzych, Katarzyna, Zetterqvist, Anna V., Wright, William R., Kirkby, Nicholas S., Mitchell, Jane A., Paul-Clark, Mark J.
Publicado 2017

COX-2 Protects against Atherosclerosis Independently of Local Vascular Prostacyclin: Identification of COX-2 Associated Pathways Implicate Rgl1 and Lymphocyte Networks

por Kirkby, Nicholas S., Lundberg, Martina H., Wright, William R., Warner, Timothy D., Paul-Clark, Mark J., Mitchell, Jane A.
Publicado 2014

Role of prostacyclin in pulmonary hypertension

por Mitchell, Jane A., Ahmetaj-Shala, Blerina, Kirkby, Nicholas S., Wright, William R., Mackenzie, Louise S., Reed, Daniel M., Mohamed, Nura
Publicado 2014

Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1

por Rauzi, Francesca, Kirkby, Nicholas S., Edin, Matthew L., Whiteford, James, Zeldin, Darryl C., Mitchell, Jane A., Warner, Timothy D.
Publicado 2016

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography

por Kirkby, Nicholas S., Low, Lucinda, Wu, Junxi, Miller, Eileen, Seckl, Jonathan R., Walker, Brian R., Webb, David J., Hadoke, Patrick W. F.
Publicado 2015

Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies()

por Kirkby, Nicholas S., Zaiss, Anne K., Wright, William R., Jiao, Jing, Chan, Melissa V., Warner, Timothy D., R. Herschman, Harvey, Mitchell, Jane A.
Publicado 2013

Temporal in vivo platelet labeling in mice reveals age-dependent receptor expression and conservation of specific mRNAs

por Armstrong, Paul C., Allan, Harriet E., Kirkby, Nicholas S., Gutmann, Clemens, Joshi, Abhishek, Crescente, Marilena, Mitchell, Jane A., Mayr, Manuel, Warner, Timothy D.
Publicado 2022

Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis

por Kirkby, Nicholas S., Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime H., Sampaio, Walkyria, Etelvino, Gisele, Leão, Nádia Miricéia, Santos, Robson A., Mitchell, Jane A.
Publicado 2016

Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox

por Mitchell, Jane A., Shala, Fisnik, Elghazouli, Youssef, Warner, Timothy D., Gaston-Massuet, Carles, Crescente, Marilena, Armstrong, Paul C., Herschman, Harvey R., Kirkby, Nicholas S.
Publicado 2019

A bioassay system of autologous human endothelial, smooth muscle cells, and leukocytes for use in drug discovery, phenotyping, and tissue engineering

por Ahmetaj‐Shala, Blerina, Kawai, Ryota, Marei, Isra, Nikolakopoulou, Zacharoula, Shih, Chih‐Chin, Konain, Bhatti, Reed, Daniel M., Mongey, Róisín, Kirkby, Nicholas S., Mitchell, Jane A.
Publicado 2019

Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation

por Mitchell, Jane A., Shala, Fisnik, Pires, Maria Elisa Lopes, Loy, Rachel Y., Ravendren, Andrew, Benson, Joshua, Urquhart, Paula, Nicolaou, Anna, Herschman, Harvey R., Kirkby, Nicholas S.
Publicado 2021

P2Y(12) receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation

por Chan, Melissa V., Knowles, Rebecca B. M., Lundberg, Martina H., Tucker, Arthur T., Mohamed, Nura A., Kirkby, Nicholas S., Armstrong, Paul C. J., Mitchell, Jane A., Warner, Timothy D.
Publicado 2016

Aspirin-triggered 15-epi-lipoxin A(4) predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test

por Kirkby, Nicholas S., Chan, Melissa V., Lundberg, Martina H., Massey, Karen A., Edmands, William M. B., MacKenzie, Louise S., Holmes, Elaine, Nicolaou, Anna, Warner, Timothy D., Mitchell, Jane A.
Publicado 2013

Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APC(Min/+) Mouse Model of Intestinal Tumorigenesis

por Paul-Clark, Mark, Elsheikh, Wagdi, Kirkby, Nicholas, Chan, Melissa, Devchand, Pallavi, Agbor, Terence A., Flannigan, Kyle L., Cheadle, Charlotte, Freydin, Maxim, Ianaro, Angela, Mitchell, Jane A., Wallace, John L.
Publicado 2016

Activation and Contraction of Human “Vascular” Smooth Muscle Cells Grown From Circulating Blood Progenitors

por Ahmetaj-Shala, Blerina, Marei, Isra, Kawai, Ryota, Rothery, Stephen, Pericleous, Charis, Mohamed, Nura A., Gashaw, Hime, Bokea, Kalliopi, Samuel, Jake, Vandenheste, Annabelle, Shala, Fisnik, Kirkby, Nicholas S., Mitchell, Jane A.
Publicado 2021