Resolving the Enigma of the Clonal Expansion of mtDNA Deletions

por Kowald, Axel, Kirkwood, Thomas B.L.
Publicado 2018

Mitochondria in the signaling pathways that control longevity and health span

por Akbari, Mansour, Kirkwood, Thomas B.L., Bohr, Vilhelm A.
Publicado 2019

A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation

por Mc Auley, Mark T, Wilkinson, Darren J, Jones, Janette JL, Kirkwood, Thomas BL
Publicado 2012

Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach

por Proctor, Carole J, Pienaar, Ilse Sanet, Elson, Joanna L, Kirkwood, Thomas BL
Publicado 2012

A modified and automated version of the 'Fluorimetric Detection of Alkaline DNA Unwinding' method to quantify formation and repair of DNA strand breaks

por Moreno-Villanueva, María, Pfeiffer, Ragen, Sindlinger, Thilo, Leake, Alan, Müller, Marcus, Kirkwood, Thomas BL, Bürkle, Alexander
Publicado 2009

The enduring effect of education-socioeconomic differences in disability trajectories from age 85 years in the Newcastle 85+ Study

por Kingston, Andrew, Davies, Karen, Collerton, Joanna, Robinson, Louise, Duncan, Rachel, Kirkwood, Thomas B.L., Jagger, Carol
Publicado 2015

A mathematical model of aging-related and cortisol induced hippocampal dysfunction

por McAuley, Mark T, Kenny, Rose Anne, Kirkwood, Thomas BL, Wilkinson, Darren J, Jones, Janette JL, Miller, Veronica M
Publicado 2009

Ten commandments for the future of ageing research in the UK: a vision for action

por Franco, Oscar H, Kirkwood, Thomas BL, Powell, Jonathan R, Catt, Michael, Goodwin, James, Ordovas, Jose M, van der Ouderaa, Frans
Publicado 2007

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

por Baines, Holly L., Stewart, James B., Stamp, Craig, Zupanic, Anze, Kirkwood, Thomas B.L., Larsson, Nils-Göran, Turnbull, Douglass M., Greaves, Laura C.
Publicado 2014

Utility of NT-proBNP as a rule-out test for left ventricular dysfunction in very old people with limiting dyspnoea: the Newcastle 85+ Study

por Collerton, Joanna, Kingston, Andrew, Yousaf, Fahad, Davies, Karen, Kenny, Antoinette, Neely, Dermot, Martin-Ruiz, Carmen, MacGowan, Guy, Robinson, Louise, Kirkwood, Thomas BL, Keavney, Bernard
Publicado 2014

Longitudinal changes in global and domain specific cognitive function in the very‐old: findings from the Newcastle 85+ Study

por Stephan, Blossom C. M., Muniz‐Terrera, Graciela, Granic, Antoneta, Collerton, Joanna, Davies, Karen, Saxby, Brian K., Wesnes, Keith A., Kirkwood, Thomas B.L., Jagger, Carol
Publicado 2017

Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old()

por Collerton, Joanna, Ashok, Deepthi, Martin-Ruiz, Carmen, Pyle, Angela, Hudson, Gavin, Yadegarfar, Mohammad, Davies, Karen, Jagger, Carol, von Zglinicki, Thomas, Kirkwood, Thomas B.L., Chinnery, Patrick F.
Publicado 2013

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts

por Stamp, Craig, Zupanic, Anze, Sachdeva, Ashwin, Stoll, Elizabeth A., Shanley, Daryl P., Mathers, John C., Kirkwood, Thomas B.L., Heer, Rakesh, Simons, Benjamin D., Turnbull, Doug M., Greaves, Laura C.
Publicado 2018

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

por Deelen, Joris, Beekman, Marian, Uh, Hae-Won, Broer, Linda, Ayers, Kristin L., Tan, Qihua, Kamatani, Yoichiro, Bennet, Anna M., Tamm, Riin, Trompet, Stella, Guðbjartsson, Daníel F., Flachsbart, Friederike, Rose, Giuseppina, Viktorin, Alexander, Fischer, Krista, Nygaard, Marianne, Cordell, Heather J., Crocco, Paolina, van den Akker, Erik B., Böhringer, Stefan, Helmer, Quinta, Nelson, Christopher P., Saunders, Gary I., Alver, Maris, Andersen-Ranberg, Karen, Breen, Marie E., van der Breggen, Ruud, Caliebe, Amke, Capri, Miriam, Cevenini, Elisa, Collerton, Joanna C., Dato, Serena, Davies, Karen, Ford, Ian, Gampe, Jutta, Garagnani, Paolo, de Geus, Eco J.C., Harrow, Jennifer, van Heemst, Diana, Heijmans, Bastiaan T., Heinsen, Femke-Anouska, Hottenga, Jouke-Jan, Hofman, Albert, Jeune, Bernard, Jonsson, Palmi V., Lathrop, Mark, Lechner, Doris, Martin-Ruiz, Carmen, Mcnerlan, Susan E., Mihailov, Evelin, Montesanto, Alberto, Mooijaart, Simon P., Murphy, Anne, Nohr, Ellen A., Paternoster, Lavinia, Postmus, Iris, Rivadeneira, Fernando, Ross, Owen A., Salvioli, Stefano, Sattar, Naveed, Schreiber, Stefan, Stefánsson, Hreinn, Stott, David J., Tiemeier, Henning, Uitterlinden, André G., Westendorp, Rudi G.J., Willemsen, Gonneke, Samani, Nilesh J., Galan, Pilar, Sørensen, Thorkild I.A., Boomsma, Dorret I., Jukema, J. Wouter, Rea, Irene Maeve, Passarino, Giuseppe, de Craen, Anton J.M., Christensen, Kaare, Nebel, Almut, Stefánsson, Kári, Metspalu, Andres, Magnusson, Patrik, Blanché, Hélène, Christiansen, Lene, Kirkwood, Thomas B.L., van Duijn, Cornelia M., Franceschi, Claudio, Houwing-Duistermaat, Jeanine J., Slagboom, P. Eline
Publicado 2014