A Multi-Compartment Hybrid Computational Model Predicts Key Roles for Dendritic Cells in Tuberculosis Infection

por Marino, Simeone, Kirschner, Denise E.
Publicado 2016

Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas

por Pienaar, Elsje, Linderman, Jennifer J., Kirschner, Denise E.
Publicado 2018

NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis

por Fallahi-Sichani, Mohammad, Kirschner, Denise E., Linderman, Jennifer J.
Publicado 2012

In silico evaluation and exploration of antibiotic tuberculosis treatment regimens

por Pienaar, Elsje, Dartois, Véronique, Linderman, Jennifer J., Kirschner, Denise E.
Publicado 2015

Strategic Priming with Multiple Antigens can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: A Computational Study

por Ziraldo, Cordelia, Gong, Chang, Kirschner, Denise E., Linderman, Jennifer J.
Publicado 2016

Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation

por Evans, Stephanie, Butler, J. Russell, Mattila, Joshua T., Kirschner, Denise E.
Publicado 2020

Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas

por Cicchese, Joseph M., Dartois, Véronique, Kirschner, Denise E., Linderman, Jennifer J.
Publicado 2020

Multi-Scale Modeling Predicts a Balance of Tumor Necrosis Factor-α and Interleukin-10 Controls the Granuloma Environment during Mycobacterium tuberculosis Infection

por Cilfone, Nicholas A., Perry, Cory R., Kirschner, Denise E., Linderman, Jennifer J.
Publicado 2013

The Role of Dimensionality in Understanding Granuloma Formation

por Marino, Simeone, Hult, Caitlin, Wolberg, Paul, Linderman, Jennifer J., Kirschner, Denise E.
Publicado 2018

Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model

por Warsinske, Hayley C., Pienaar, Elsje, Linderman, Jennifer J., Mattila, Joshua T., Kirschner, Denise E.
Publicado 2017

Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination

por Hult, Caitlin, Mattila, Joshua T., Gideon, Hannah P., Linderman, Jennifer J., Kirschner, Denise E.
Publicado 2021

Concomitant immunity to M. tuberculosis infection

por Joslyn, Louis R., Flynn, JoAnne L., Kirschner, Denise E., Linderman, Jennifer J.
Publicado 2022

Tuneable resolution as a systems biology approach for multi-scale, multi-compartment computational models

por Kirschner, Denise E, Hunt, C Anthony, Marino, Simeone, Fallahi-Sichani, Mohammad, Linderman, Jennifer J
Publicado 2014

Identification of Key Processes that Control Tumor Necrosis Factor Availability in a Tuberculosis Granuloma

por Fallahi-Sichani, Mohammad, Schaller, Matthew A., Kirschner, Denise E., Kunkel, Steven L., Linderman, Jennifer J.
Publicado 2010

Dose finding for new vaccines: The role for immunostimulation/immunodynamic modelling

por Rhodes, Sophie J., Knight, Gwenan M., Kirschner, Denise E., White, Richard G., Evans, Thomas G.
Publicado 2019

Disease phenotypic and geospatial features vary across genetic lineages for Tuberculosis within Arkansas, 2010–2020

por Renardy, Marissa E., Gillen, Craig, Yang, Zhenhua, Mukasa, Leonard, Bates, Joseph, Butler, Russ, Kirschner, Denise E.
Publicado 2023

Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach

por Pienaar, Elsje, Sarathy, Jansy, Prideaux, Brendan, Dietzold, Jillian, Dartois, Véronique, Kirschner, Denise E., Linderman, Jennifer J.
Publicado 2017

Differences in Reactivation of Tuberculosis Induced from Anti-TNF Treatments Are Based on Bioavailability in Granulomatous Tissue

por Marino, Simeone, Sud, Dhruv, Plessner, Hillarie, Lin, Philana Ling, Chan, John, Flynn, JoAnne L, Kirschner, Denise E
Publicado 2007

Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis

por Warsinske, Hayley C., Wheaton, Amanda K., Kim, Kevin K., Linderman, Jennifer J., Moore, Bethany B., Kirschner, Denise E.
Publicado 2016

Semi-automated colony-forming unit counting for biosafety level 3 laboratories

por Janakiraman, Soorya, Engels, Sophie, Nanda, Pariksheet, Budak, Maral, Greenstein, Talia, Moraes, Mariana Pereira, Aldridge, Bree B., Kirschner, Denise E.
Publicado 2023