Structural insight and stability of TNFR-Fc fusion protein (Etanercept) produced by using transgenic silkworms

por Kiyoshi, Masato, Tatematsu, Ken-Ichiro, Tada, Minoru, Sezutsu, Hideki, Shibata, Hiroko, Ishii-Watabe, Akiko
Publicado 2020

Biophysical Characterization of the Contribution of the Fab Region to the IgG-FcγRIIIa Interaction

por Kosuge, Hirofumi, Nagatoishi, Satoru, Kiyoshi, Masato, Ishii-Watabe, Akiko, Terao, Yosuke, Ide, Teruhiko, Tsumoto, Kouhei
Publicado 2022

Exploring designability of electrostatic complementarity at an antigen-antibody interface directed by mutagenesis, biophysical analysis, and molecular dynamics simulations

por Yoshida, Kouhei, Kuroda, Daisuke, Kiyoshi, Masato, Nakakido, Makoto, Nagatoishi, Satoru, Soga, Shinji, Shirai, Hiroki, Tsumoto, Kouhei
Publicado 2019

Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody

por Akiba, Hiroki, Tamura, Hiroko, Kiyoshi, Masato, Yanaka, Saeko, Sugase, Kenji, Caaveiro, Jose M. M., Tsumoto, Kouhei
Publicado 2019

Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI

por Kiyoshi, Masato, Caaveiro, Jose M.M., Kawai, Takeaki, Tashiro, Shinya, Ide, Teruhiko, Asaoka, Yoshiharu, Hatayama, Kouta, Tsumoto, Kouhei
Publicado 2015

Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies

por Aoyama, Michihiko, Hashii, Noritaka, Tsukimura, Wataru, Osumi, Kenji, Harazono, Akira, Tada, Minoru, Kiyoshi, Masato, Matsuda, Akio, Ishii-Watabe, Akiko
Publicado 2019

Highly sensitive HPLC analysis and biophysical characterization of N‐glycans of IgG‐Fc domain in comparison between CHO and 293 cells using FcγRIIIa ligand

por Kosuge, Hirofumi, Nagatoishi, Satoru, Kiyoshi, Masato, Ishii‐Watabe, Akiko, Tanaka, Toru, Terao, Yosuke, Oe, Seigo, Ide, Teruhiko, Tsumoto, Kouhei
Publicado 2020

Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Ant...

por Kiyoshi, Masato, Caaveiro, Jose M. M., Miura, Eri, Nagatoishi, Satoru, Nakakido, Makoto, Soga, Shinji, Shirai, Hiroki, Kawabata, Shigeki, Tsumoto, Kouhei
Publicado 2014

Specific peptide conjugation to a therapeutic antibody leads to enhanced therapeutic potency and thermal stability by reduced Fc dynamics

por Kiyoshi, Masato, Nakakido, Makoto, Rafique, Abdur, Tada, Minoru, Aoyama, Michihiko, Terao, Yosuke, Nagatoishi, Satoru, Shibata, Hiroko, Ide, Teruhiko, Tsumoto, Kouhei, Ito, Yuji, Ishii-Watabe, Akiko
Publicado 2023

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column

por Kiyoshi, Masato, Caaveiro, Jose M. M., Tada, Minoru, Tamura, Hiroko, Tanaka, Toru, Terao, Yosuke, Morante, Koldo, Harazono, Akira, Hashii, Noritaka, Shibata, Hiroko, Kuroda, Daisuke, Nagatoishi, Satoru, Oe, Seigo, Ide, Teruhiko, Tsumoto, Kouhei, Ishii-Watabe, Akiko
Publicado 2018