Nucleoside Sensing

por Fokkens, Michael, Klärner, Frank-Gerrit, Schrader, Thomas
Publicado 2006

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation

por Hadrovic, Inesa, Rebmann, Philipp, Klärner, Frank-Gerrit, Bitan, Gal, Schrader, Thomas
Publicado 2019

Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins’ toxicity

por Attar, Aida, Chan, Wai-Ting Coco, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Publicado 2014

Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03

por Zheng, Xueyun, Liu, Deyu, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal, Bowers, Michael T.
Publicado 2015

Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer

por Xu, Na, Bitan, Gal, Schrader, Thomas, Klärner, Frank‐Gerrit, Osinska, Hanna, Robbins, Jeffrey
Publicado 2017

Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes

por Li, Zizheng, Siddique, Ibrar, Hadrović, Inesa, Kirupakaran, Abbna, Li, Jiwen, Zhang, Ye, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Publicado 2021

Molecular Tweezers Targeting Transthyretin Amyloidosis

por Ferreira, Nelson, Pereira-Henriques, Alda, Attar, Aida, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal, Gales, Luís, Saraiva, Maria João, Almeida, Maria Rosário
Publicado 2014

Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos

por Lulla, Aaron, Barnhill, Lisa, Bitan, Gal, Ivanova, Magdalena I., Nguyen, Binh, O’Donnell, Kelley, Stahl, Mark C., Yamashiro, Chase, Klärner, Frank-Gerrit, Schrader, Thomas, Sagasti, Alvaro, Bronstein, Jeff M.
Publicado 2016

The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

por Di, Jing, Siddique, Ibrar, Li, Zizheng, Malki, Ghattas, Hornung, Simon, Dutta, Suman, Hurst, Ian, Ishaaya, Ella, Wang, Austin, Tu, Sally, Boghos, Ani, Ericsson, Ida, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Publicado 2021

Correction to: The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

por Di, Jing, Siddique, Ibrar, Li, Zizheng, Malki, Ghattas, Hornung, Simon, Dutta, Suman, Hurst, Ian, Ishaaya, Ella, Wang, Austin, Tu, Sally, Boghos, Ani, Ericsson, Ida, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Publicado 2021

The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease

por Monaco, Antonio, Maffia, Veronica, Sorrentino, Nicolina Cristina, Sambri, Irene, Ezhova, Yulia, Giuliano, Teresa, Cacace, Vincenzo, Nusco, Edoardo, De Risi, Maria, De Leonibus, Elvira, Schrader, Thomas, Klärner, Frank-Gerrit, Bitan, Gal, Fraldi, Alessandro
Publicado 2020

The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease

por Monaco, Antonio, Maffia, Veronica, Sorrentino, Nicolina Cristina, Sambri, Irene, Ezhova, Yulia, Giuliano, Teresa, Cacace, Vincenzo, Nusco, Edoardo, De Risi, Maria, De Leonibus, Elvira, Schrader, Thomas, Klärner, Frank-Gerrit, Bitan, Gal, Fraldi, Alessandro
Publicado 2022

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors

por Despres, Clément, Di, Jing, Cantrelle, François-Xavier, Li, Zizheng, Huvent, Isabelle, Chambraud, Béatrice, Zhao, Jing, Chen, Jianle, Chen, Shiguo, Lippens, Guy, Zhang, Fuming, Linhardt, Robert, Wang, Chunyu, Klärner, Frank-Gerrit, Schrader, Thomas, Landrieu, Isabelle, Bitan, Gal, Smet-Nocca, Caroline
Publicado 2019

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease

por Bengoa-Vergniory, Nora, Faggiani, Emilie, Ramos-Gonzalez, Paula, Kirkiz, Ecem, Connor-Robson, Natalie, Brown, Liam V., Siddique, Ibrar, Li, Zizheng, Vingill, Siv, Cioroch, Milena, Cavaliere, Fabio, Threlfell, Sarah, Roberts, Bradley, Schrader, Thomas, Klärner, Frank-Gerrit, Cragg, Stephanie, Dehay, Benjamin, Bitan, Gal, Matute, Carlos, Bezard, Erwan, Wade-Martins, Richard
Publicado 2020

A molecular tweezer antagonizes seminal amyloids and HIV infection

por Lump, Edina, Castellano, Laura M, Meier, Christoph, Seeliger, Janine, Erwin, Nelli, Sperlich, Benjamin, Stürzel, Christina M, Usmani, Shariq, Hammond, Rebecca M, von Einem, Jens, Gerold, Gisa, Kreppel, Florian, Bravo-Rodriguez, Kenny, Pietschmann, Thomas, Holmes, Veronica M, Palesch, David, Zirafi, Onofrio, Weissman, Drew, Sowislok, Andrea, Wettig, Burkhard, Heid, Christian, Kirchhoff, Frank, Weil, Tanja, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal, Sanchez-Garcia, Elsa, Winter, Roland, Shorter, James, Münch, Jan
Publicado 2015

Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses

por Weil, Tatjana, Kirupakaran, Abbna, Le, My-Hue, Rebmann, Philipp, Mieres-Perez, Joel, Issmail, Leila, Conzelmann, Carina, Müller, Janis A., Rauch, Lena, Gilg, Andrea, Wettstein, Lukas, Groß, Rüdiger, Read, Clarissa, Bergner, Tim, Pålsson, Sandra Axberg, Uhlig, Nadja, Eberlein, Valentina, Wöll, Heike, Klärner, Frank-Gerrit, Stenger, Steffen, Kümmerer, Beate M., Streeck, Hendrik, Fois, Giorgio, Frick, Manfred, Braubach, Peter, Spetz, Anna-Lena, Grunwald, Thomas, Shorter, James, Sanchez-Garcia, Elsa, Schrader, Thomas, Münch, Jan
Publicado 2022

Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers

por Weil, Tatjana, Groß, Rüdiger, Röcker, Annika, Bravo-Rodriguez, Kenny, Heid, Christian, Sowislok, Andrea, Le, My-Hue, Erwin, Nelli, Dwivedi, Mridula, Bart, Stephen M., Bates, Paul, Wettstein, Lukas, Müller, Janis A., Harms, Mirja, Sparrer, Konstantin, Ruiz-Blanco, Yasser B., Stürzel, Christina M., von Einem, Jens, Lippold, Sina, Read, Clarissa, Walther, Paul, Hebel, Marco, Kreppel, Florian, Klärner, Frank-Gerrit, Bitan, Gal, Ehrmann, Michael, Weil, Tanja, Winter, Roland, Schrader, Thomas, Shorter, James, Sanchez-Garcia, Elsa, Münch, Jan
Publicado 2020