Negative charge and membrane-tethered viral 3B cooperate to recruit viral RNA dependent RNA polymerase 3D(pol)

por Dubankova, Anna, Humpolickova, Jana, Klima, Martin, Boura, Evzen
Publicado 2017

Structural analysis of the putative SARS-CoV-2 primase complex

por Konkolova, Eva, Klima, Martin, Nencka, Radim, Boura, Evzen
Publicado 2020

Phosphatidylinositol 4-kinase IIIβ (PI4KB) forms highly flexible heterocomplexes that include ACBD3, 14-3-3, and Rab11 proteins

por Chalupska, Dominika, Różycki, Bartosz, Humpolickova, Jana, Faltova, Lenka, Klima, Martin, Boura, Evzen
Publicado 2019

Coronaviral RNA-methyltransferases: function, structure and inhibition

por Nencka, Radim, Silhan, Jan, Klima, Martin, Otava, Tomas, Kocek, Hugo, Krafcikova, Petra, Boura, Evzen
Publicado 2022

Crystal Structure of the ORP8 Lipid Transport ORD Domain: Model of Lipid Transport

por Eisenreichova, Andrea, Klima, Martin, Anila, Midhun Mohan, Koukalova, Alena, Humpolickova, Jana, Różycki, Bartosz, Boura, Evzen
Publicado 2023

Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase

por Silhan, Jan, Klima, Martin, Otava, Tomas, Skvara, Petr, Chalupska, Dominika, Chalupsky, Karel, Kozic, Jan, Nencka, Radim, Boura, Evzen
Publicado 2023

The mycobacterial guaB1 gene encodes a guanosine 5′‐monophosphate reductase with a cystathionine‐β‐synthase domain

por Knejzlík, Zdeněk, Doležal, Michal, Herkommerová, Klára, Clarova, Kamila, Klíma, Martin, Dedola, Matteo, Zborníková, Eva, Rejman, Dominik, Pichová, Iva
Publicado 2022

Localization of SARS-CoV-2 Capping Enzymes Revealed by an Antibody against the nsp10 Subunit

por Horova, Vladimira, Landova, Barbora, Hodek, Jan, Chalupsky, Karel, Krafcikova, Petra, Chalupska, Dominika, Duchoslav, Vojtech, Weber, Jan, Boura, Evzen, Klima, Martin
Publicado 2021

Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites

por Horova, Vladimira, Lyoo, Heyrhyoung, Różycki, Bartosz, Chalupska, Dominika, Smola, Miroslav, Humpolickova, Jana, Strating, Jeroen R. P. M., van Kuppeveld, Frank J. M., Boura, Evzen, Klima, Martin
Publicado 2019

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene

por Hall, Arnaldur, Meyle, Kathrine Damm, Lange, Marina Krarup, Klima, Martin, Sanderhoff, May, Dahl, Christina, Abildgaard, Cecilie, Thorup, Katrine, Moghimi, Seyed Moein, Jensen, Per Bo, Bartek, Jiri, Guldberg, Per, Christensen, Claus
Publicado 2013

Crystal structure of SARS‐CoV‐2 nsp10–nsp16 in complex with small molecule inhibitors, SS148 and WZ16

por Klima, Martin, Khalili Yazdi, Aliakbar, Li, Fengling, Chau, Irene, Hajian, Taraneh, Bolotokova, Albina, Kaniskan, H. Ümit, Han, Yulin, Wang, Ke, Li, Deyao, Luo, Minkui, Jin, Jian, Boura, Evzen, Vedadi, Masoud
Publicado 2022

Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein

por Klima, Martin, Tóth, Dániel J., Hexnerova, Rozalie, Baumlova, Adriana, Chalupska, Dominika, Tykvart, Jan, Rezabkova, Lenka, Sengupta, Nivedita, Man, Petr, Dubankova, Anna, Humpolickova, Jana, Nencka, Radim, Veverka, Vaclav, Balla, Tamas, Boura, Evzen
Publicado 2016

SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses

por Li, Fengling, Ghiabi, Pegah, Hajian, Taraneh, Klima, Martin, Li, Alice Shi Ming, Khalili Yazdi, Aliakbar, Chau, Irene, Loppnau, Peter, Kutera, Maria, Seitova, Almagul, Bolotokova, Albina, Hutchinson, Ashley, Perveen, Sumera, Boura, Evzen, Vedadi, Masoud
Publicado 2023

Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes

por Kortus, Stepan, Rehakova, Kristyna, Klima, Martin, Kolcheva, Marharyta, Ladislav, Marek, Langore, Emily, Barackova, Petra, Netolicky, Jakub, Misiachna, Anna, Hemelikova, Katarina, Humpolickova, Jana, Chalupska, Dominika, Silhan, Jan, Kaniakova, Martina, Hrcka Krausova, Barbora, Boura, Evzen, Zapotocky, Martin, Horak, Martin
Publicado 2023

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

por Nigam, AkshatKumar, Hurley, Matthew F. D., Li, Fengling, Konkoǐová, Eva, Klíma, Martin, Trylčová, Jana, Pollice, Robert, Çinaroǧlu, Süleyman Selim, Levin-Konigsberg, Roni, Handjaya, Jasemine, Schapira, Matthieu, Chau, Irene, Perveen, Sumera, Ng, Ho-Leung, Ümit Kaniskan, H., Han, Yulin, Singh, Sukrit, Gorgulla, Christoph, Kundaje, Anshul, Jin, Jian, Voelz, Vincent A., Weber, Jan, Nencka, Radim, Boura, Evzen, Vedadi, Masoud, Aspuru-Guzik, Alán
Publicado 2023