A crossover study evaluating the sex‐dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects

por Hijma, Hemme, Koopmans, Ingrid, Klaassen, Erica, Doll, Robert Jan, Zuiker, Rob, Groeneveld, Geert Jan
Publicado 2022

The ultraviolet B inflammation model: Postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects

por Siebenga, Pieter S., van Amerongen, Guido, Klaassen, Erica S., de Kam, Marieke L., Rissmann, Robert, Groeneveld, Geert Jan
Publicado 2019

Impact of oral administration of single strain Lactococcus lactis spp. cremoris on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized place...

por Saghari, Mahdi, Gal, Pim, Grievink, Hendrika W., Klaassen, Erica S., Itano, Andrea, McHale, Duncan, Moerland, Matthijs
Publicado 2022

First in human study with a prodrug of galantamine: Improved benefit-risk ratio?

por Baakman, Anne C., 't Hart, Ellen, Kay, Denis G., Stevens, Jasper, Klaassen, Erica S., Maelicke, Alfred, Groeneveld, Geert J.
Publicado 2016

The Effect of a 13-Valent Conjugate Pneumococcal Vaccine on Circulating Antibodies Against Oxidized LDL and Phosphorylcholine in Man, A Randomized Placebo-Controlled Clinical Trial

por Grievink, Hendrika W., Gal, Pim, Ozsvar Kozma, Maria, Klaassen, Erica S., Kuiper, Johan, Burggraaf, Jacobus, Binder, Christoph J., Moerland, Matthijs
Publicado 2020

Central nervous system effects of TAK-653, an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole receptor (AMPAR) positive allosteric modulator in healthy volunteers

por Dijkstra, Francis, O’Donnell, Patricio, Klaassen, Erica, Buhl, Derek, Asgharnejad, Mahnaz, Rosen, Laura, Zuiker, Rob, van Gerven, Joop, Jacobs, Gabriël
Publicado 2022

Safety and Pharmacokinetics of HTL0018318, a Novel M(1) Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects

por Bakker, Charlotte, van der Aart, Jasper, Labots, Geert, Liptrot, Jan, Cross, David M., Klaassen, Erica S., Dickinson, Steve, Tasker, Tim, Groeneveld, Geert Jan
Publicado 2021

First‐in‐human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS‐penetrant soluble guanylyl cyclase stimulator

por van Kraaij, Sebastiaan J. W., Gal, Pim, Borghans, Laura G. J. M., Klaassen, Erica S., Dijkstra, Francis, Winrow, Christopher, Glasser, Chad, Groeneveld, Geert Jan
Publicado 2023

Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

por Bakker, Charlotte, van der Aart, Jasper, Hart, Ellen P., Klaassen, Erica S., Bergmann, Kirsten R., van Esdonk, Michiel J., Kay, Denis G., Groeneveld, Geert Jan
Publicado 2020

Symptomatic Treatment of Vascular Cognitive Impairment (STREAM-VCI): Protocol for a Cross-Over Trial

por Leijenaar, Jolien Fleur, Groeneveld, Geert Jan, van der Flier, Wiesje Maria, Scheltens, Philip, Klaassen, Erica Surya, Weinstein, Henry Chanoch, Biessels, Geert Jan, Barkhof, Frederik, Prins, Niels Daniël
Publicado 2018

Comprehensive, Multimodal Characterization of an Imiquimod‐Induced Human Skin Inflammation Model for Drug Development

por van der Kolk, Tessa, Assil, Salma, Rijneveld, Rianne, Klaassen, Erica S., Feiss, Gary, Florencia, Edwin, Prens, Errol P., Burggraaf, Jacobus, Moerland, Matthijs, Rissmann, Robert, van Doorn, Martijn B.A.
Publicado 2018

First Clinical Study with AP30663 ‐ a K(Ca)2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation

por Gal, Pim, Klaassen, Erica S., Bergmann, Kirsten R., Saghari, Mahdi, Burggraaf, Jacobus, Kemme, Michiel J. B., Sylvest, Christina, Sørensen, Ulrik, Bentzen, Bo H., Grunnet, Morten, Diness, Jonas G., Edvardsson, Nils
Publicado 2020

First‐in‐human trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of STR‐324, a dual enkephalinase inhibitor for pain management

por Moss, Laurence M., Berends, Cecile L., van Brummelen, Emilie M. J., Kamerling, Ingrid M. C., Klaassen, Erica S., Bergmann, Kirsten, Ville, Vanessa, Juarez‐Perez, Victor, Benichou, Annie‐Claude, Groeneveld, Geert Jan
Publicado 2021

Methylphenidate and galantamine in patients with vascular cognitive impairment–the proof-of-principle study STREAM-VCI

por Leijenaar, Jolien F., Groeneveld, Geert Jan, Klaassen, Erica S., Leeuwis, Anna E., Scheltens, Philip, Weinstein, Henry C., van Gerven, Joop M. A., Barkhof, Frederik, van der Flier, Wiesje M., Prins, Niels D.
Publicado 2020

Identification of peripheral vascular function measures and circulating biomarkers of mitochondrial function in patients with mitochondrial disease

por van Kraaij, Sebastiaan J. W., Pereira, Diana R., Smal, Bastiaan, Summo, Luciana, Konkel, Anne, Lossie, Janine, Busjahn, Andreas, Grammatopoulos, Tom N., Klaassen, Erica, Fischer, Robert, Schunck, Wolf‐Hagen, Gal, Pim, Moerland, Matthijs
Publicado 2023

Omiganan Enhances Imiquimod‐Induced Inflammatory Responses in Skin of Healthy Volunteers

por Niemeyer‐van der Kolk, Tessa, Assil, Salma, Buters, Thomas P., Rijsbergen, Melanie, Klaassen, Erica S., Feiss, Gary, Florencia, Edwin, Prens, Errol P., Burggraaf, Jacobus, van Doorn, Martijn B.A., Rissmann, Robert, Moerland, Matthijs
Publicado 2020

Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M(1) receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending...

por Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Doll, Robert Jan, Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Cross, David M., Groeneveld, Geert Jan, Nathan, Pradeep J.
Publicado 2021

Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M(1)‐acetylcholine receptor agonist: A randomized cross‐over trial

por Bakker, Charlotte, Prins, Samantha, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Stevens, Jasper, Cross, David M., Tasker, Tim, Nathan, Pradeep J., Groeneveld, Geert Jan
Publicado 2021

Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double‐blind, placebo‐controlled cross‐over trial

por Kanhai, Kawita M. S., Nij Bijvank, Jenny A., Wagenaar, Yorick L., Klaassen, Erica S., Lim, KyoungSoo, Bergheanu, Sandrin C., Petzold, Axel, Verma, Ajay, Hesterman, Jacob, Wattjes, Mike P., Uitdehaag, Bernard M. J., van Rijn, Laurentius J., Groeneveld, Geert Jan
Publicado 2019

OX40L Inhibition Suppresses KLH‐driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof‐of‐Pharmacology for KY1005

por Saghari, Mahdi, Gal, Pim, Gilbert, Sally, Yateman, Martin, Porter‐Brown, Ben, Brennan, Nuala, Quaratino, Sonia, Wilson, Rosamund, Grievink, Hendrika W., Klaassen, Erica S., Bergmann, Kirsten R., Burggraaf, Jacobus, van Doorn, Martijn B. A., Powell, John, Moerland, Matthijs, Rissmann, Robert
Publicado 2022