Disruptive Technology: CRISPR/Cas-Based Tools and Approaches

por Patsali, Petros, Kleanthous, Marina, Lederer, Carsten W.
Publicado 2019

Rare Opportunities: CRISPR/Cas-Based Therapy Development for Rare Genetic Diseases

por Papasavva, Panayiota, Kleanthous, Marina, Lederer, Carsten W.
Publicado 2019

Therapy Development by Genome Editing of Hematopoietic Stem Cells

por Koniali, Lola, Lederer, Carsten W., Kleanthous, Marina
Publicado 2021

Genotyping of BCL11A and HBS1L-MYB SNPs associated with fetal haemoglobin levels: a SNaPshot minisequencing approach

por Fanis, Pavlos, Kousiappa, Ioanna, Phylactides, Marios, Kleanthous, Marina
Publicado 2014

Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content

por Kyriakou, Kalia, W. Lederer, Carsten, Kleanthous, Marina, Drousiotou, Anthi, Malekkou, Anna
Publicado 2020

IthaPhen: An Interactive Database of Genotype-Phenotype Data for Hemoglobinopathies

por Xenophontos, Maria, Minaidou, Anna, Stephanou, Coralea, Tamana, Stella, Kleanthous, Marina, Kountouris, Petros
Publicado 2023

Genetic Modifiers at the Crossroads of Personalised Medicine for Haemoglobinopathies

por Stephanou, Coralea, Tamana, Stella, Minaidou, Anna, Papasavva, Panayiota, Kleanthous, Marina, Kountouris, Petros
Publicado 2019

IthaGenes: An Interactive Database for Haemoglobin Variations and Epidemiology

por Kountouris, Petros, Lederer, Carsten W., Fanis, Pavlos, Feleki, Xenia, Old, John, Kleanthous, Marina
Publicado 2014

Fast Temperature-Gradient COLD PCR for the enrichment of the paternally inherited SNPs in cell free fetal DNA; an application to non-invasive prenatal diagnosis of β-thalassaemia

por Byrou, Stefania, Makrigiorgos, G. Mike, Christofides, Agathoklis, Kallikas, Ioannis, Papasavva, Thessalia, Kleanthous, Marina
Publicado 2018

Selection and Identification of Skeletal-Muscle-Targeted RNA Aptamers

por Philippou, Styliana, Mastroyiannopoulos, Nikolaos P., Makrides, Neoklis, Lederer, Carsten W., Kleanthous, Marina, Phylactou, Leonidas A.
Publicado 2018

A novel mutation in the erythroid transcription factor KLF1 is likely responsible for ameliorating β‐thalassemia major

por Fanis, Pavlos, Kousiappa, Ioanna, Phylactides, Marios, Kyrri, Andreani, Hadjigavriel, Michael, Christou, Soteroula, Sitarou, Maria, Kleanthous, Marina
Publicado 2019

Relative and Absolute Quantification of Aberrant and Normal Splice Variants in HBB(IVSI−110 (G > A)) β-Thalassemia

por Patsali, Petros, Papasavva, Panayiota, Christou, Soteroulla, Sitarou, Maria, Antoniou, Michael N., Lederer, Carsten W., Kleanthous, Marina
Publicado 2020

Effect of HBB genotype on survival in a cohort of transfusion-dependent thalassemia patients in Cyprus

por Kountouris, Petros, Michailidou, Kyriaki, Christou, Soteroula, Hadjigavriel, Michael, Sitarou, Maria, Kolnagou, Anita, Kleanthous, Marina, Telfer, Paul
Publicado 2020

Recent trends in the gene therapy of β-thalassemia

por Finotti, Alessia, Breda, Laura, Lederer, Carsten W, Bianchi, Nicoletta, Zuccato, Cristina, Kleanthous, Marina, Rivella, Stefano, Gambari, Roberto
Publicado 2015

CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation

por Papasavva, Panayiota L., Patsali, Petros, Loucari, Constantinos C., Kurita, Ryo, Nakamura, Yukio, Kleanthous, Marina, Lederer, Carsten W.
Publicado 2022

A Novel Tool for the Analysis and Detection of Copy Number Variants Associated with Haemoglobinopathies

por Minaidou, Anna, Tamana, Stella, Stephanou, Coralea, Xenophontos, Maria, Harteveld, Cornelis L., Bento, Celeste, Kleanthous, Marina, Kountouris, Petros
Publicado 2022

The first family with Tay-Sachs disease in Cyprus: Genetic analysis reveals a nonsense (c.78G>A) and a silent (c.1305C>T) mutation and allows preimplantation genetic diagnosis

por Georgiou, Theodoros, Christopoulos, George, Anastasiadou, Violetta, Hadjiloizou, Stavros, Cregeen, David, Jackson, Marie, Mavrikiou, Gavriella, Kleanthous, Marina, Drousiotou, Anthi
Publicado 2014

Proteomic Studies for the Investigation of γ-Globin Induction by Decitabine in Human Primary Erythroid Progenitor Cultures

por Theodorou, Andria, Phylactides, Marios, Katsantoni, Eleni, Vougas, Kostas, Garbis, Spyros D., Fanis, Pavlos, Sitarou, Maria, Thein, Swee Lay, Kleanthous, Marina
Publicado 2020

The Optimized γ-Globin Lentiviral Vector GGHI-mB-3D Leads to Nearly Therapeutic HbF Levels In Vitro in CD34(+) Cells from Sickle Cell Disease Patients

por Drakopoulou, Ekati, Georgomanoli, Maria, Lederer, Carsten W., Panetsos, Fottes, Kleanthous, Marina, Voskaridou, Ersi, Valakos, Dimitrios, Papanikolaou, Eleni, Anagnou, Nicholas P.
Publicado 2022

Distinct miRNA Signatures and Networks Discern Fetal from Adult Erythroid Differentiation and Primary from Immortalized Erythroid Cells

por Papasavva, Panayiota L., Papaioannou, Nikoletta Y., Patsali, Petros, Kurita, Ryo, Nakamura, Yukio, Sitarou, Maria, Christou, Soteroulla, Kleanthous, Marina, Lederer, Carsten W.
Publicado 2021