Stacking up the armory against viruses

por Klebl, Bert M
Publicado 2004

White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy

por Dahl, Edgar, Villwock, Sophia, Habenberger, Peter, Choidas, Axel, Rose, Michael, Klebl, Bert M.
Publicado 2022

Blocking the Farnesyl Pocket of PDEδ Reduces Rheb-Dependent mTORC1 Activation and Survival of Tsc2-Null Cells

por Armijo, Marisol Estrella, Escalona, Emilia, Peña, Daniela, Farias, Alejandro, Morin, Violeta, Baumann, Matthias, Klebl, Bert Matthias, Pincheira, Roxana, Castro, Ariel Fernando
Publicado 2022

Sequence‐Selective Covalent CaaX‐Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling

por Franz, Matthias, Mörchen, Britta, Degenhart, Carsten, Gülden, Daniel, Shkura, Oleksandr, Wolters, Dirk, Koch, Uwe, Klebl, Bert, Stoll, Raphael, Helfrich, Iris, Scherkenbeck, Jürgen
Publicado 2021

Synthesis, Biological Evaluation, and Binding Mode of a New Class of Oncogenic K‐Ras4b Inhibitors

por Jeuken, Stephan, Shkura, Oleksandr, Röger, Marc, Brickau, Victoria, Choidas, Axel, Degenhart, Carsten, Gülden, Daniel, Klebl, Bert, Koch, Uwe, Stoll, Raphael, Scherkenbeck, Jürgen
Publicado 2022

Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target

por Tillmanns, Julia, Häge, Sigrun, Borst, Eva Maria, Wardin, Julia, Eickhoff, Jan, Klebl, Bert, Wagner, Sabrina, Wangen, Christina, Hahn, Friedrich, Socher, Eileen, Marschall, Manfred
Publicado 2023

Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Streptomyces Isolate

por Sagurna, Leonie, Heinrich, Sascha, Kaufmann, Lara-Sophie, Rückert-Reed, Christian, Busche, Tobias, Wolf, Alexander, Eickhoff, Jan, Klebl, Bert, Kalinowski, Jörn, Bandow, Julia E.
Publicado 2023

A Role for Myosin-I in Actin Assembly through Interactions with Vrp1p, Bee1p, and the Arp2/3 Complex

por Evangelista, Marie, Klebl, Bert M., Tong, Amy H.Y., Webb, Bradley A., Leeuw, Thomas, Leberer, Ekkehard, Whiteway, Malcolm, Thomas, David Y., Boone, Charles
Publicado 2000

Anti-leukemic effect of CDK9 inhibition in T-cell prolymphocytic leukemia

por Johansson, Patricia, Dierichs, Laura, Klein-Hitpass, Ludger, Bergmann, Anke K., Möllmann, Michael, Menninger, Sascha, Habenberger, Peter, Klebl, Bert, Siveke, Jens T., Dührsen, Ulrich, Choidas, Axel, Dürig, Jan
Publicado 2020

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

por Schütz, Martin, Wangen, Christina, Sommerer, Mona, Kögler, Melanie, Eickhoff, Jan, Degenhart, Carsten, Klebl, Bert, Naing, Zin, Egilmezer, Ece, Hamilton, Stuart T., Rawlinson, William D., Sticht, Heinrich, Marschall, Manfred
Publicado 2023

Potent anti-leukemic activity of a specific cyclin-dependent kinase 9 inhibitor in mouse models of chronic lymphocytic leukemia

por Göthert, Joachim R., Imsak, Roze, Möllmann, Michael, Kesper, Stefanie, Göbel, Maria, Dührsen, Ulrich, Scholz, Arne, Lücking, Ulrich, Baumann, Matthias, Unger, Anke, Schultz-Fademrecht, Carsten, Klebl, Bert, Eickhoff, Jan, Choidas, Axel, Dürig, Jan
Publicado 2018

Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form

por Aarhus, Thomas Ihle, Bjørnstad, Frithjof, Wolowczyk, Camilla, Larsen, Kristin Uhlving, Rognstad, Line, Leithaug, Trygve, Unger, Anke, Habenberger, Peter, Wolf, Alexander, Bjørkøy, Geir, Pridans, Clare, Eickhoff, Jan, Klebl, Bert, Hoff, Bård H., Sundby, Eirik
Publicado 2023

Structure–Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt

por Meijer, Femke A., Saris, Annet O.W.M., Doveston, Richard G., Oerlemans, Guido J.M., de Vries, Rens M.J.M., Somsen, Bente A., Unger, Anke, Klebl, Bert, Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Publicado 2021

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A

por Cheung, Sin Ying, Henrot, Matthias, Al-Saad, Mohammad, Baumann, Matthias, Muller, Heiko, Unger, Anke, Rubaiy, Hussein N., Mathar, Ilka, Dinkel, Klaus, Nussbaumer, Peter, Klebl, Bert, Freichel, Marc, Rode, Baptiste, Trainor, Sebastian, Clapcote, Steven J., Christmann, Mathias, Waldmann, Herbert, Abbas, Syed Khawar, Beech, David J., Vasudev, Naveen S.
Publicado 2018

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

por Kaufmann, Johanna, Blum, Nina Kathleen, Nagel, Falko, Schuler, Anna, Drube, Julia, Degenhart, Carsten, Engel, Julian, Eickhoff, Jan Eicke, Dasgupta, Pooja, Fritzwanker, Sebastian, Guastadisegni, Maria, Schulte, Clemens, Miess-Tanneberg, Elke, Maric, Hans Michael, Spetea, Mariana, Kliewer, Andrea, Baumann, Matthias, Klebl, Bert, Reinscheid, Rainer K., Hoffmann, Carsten, Schulz, Stefan
Publicado 2022

Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer

por Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Bömer, Ulf, Schäfer, Martina, Eis, Knut, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz‐Fademrecht, Carsten, Rühter, Gerd, Eickhoff, Jan, Brands, Michael
Publicado 2017

Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo

por Reinhardt, Lydia, Kordes, Susanne, Reinhardt, Peter, Glatza, Michael, Baumann, Matthias, Drexler, Hannes C.A., Menninger, Sascha, Zischinsky, Gunther, Eickhoff, Jan, Fröb, Claudia, Bhattarai, Prabesh, Arulmozhivarman, Guruchandar, Marrone, Lara, Janosch, Antje, Adachi, Kenjiro, Stehling, Martin, Anderson, Eric N., Abo-Rady, Masin, Bickle, Marc, Pandey, Udai Bhan, Reimer, Michell M., Kizil, Caghan, Schöler, Hans R., Nussbaumer, Peter, Klebl, Bert, Sterneckert, Jared L.
Publicado 2019

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma

por Brägelmann, Johannes, Dammert, Marcel A., Dietlein, Felix, Heuckmann, Johannes M., Choidas, Axel, Böhm, Stefanie, Richters, André, Basu, Debjit, Tischler, Verena, Lorenz, Carina, Habenberger, Peter, Fang, Zhizhou, Ortiz-Cuaran, Sandra, Leenders, Frauke, Eickhoff, Jan, Koch, Uwe, Getlik, Matthäus, Termathe, Martin, Sallouh, Muhammad, Greff, Zoltán, Varga, Zoltán, Balke-Want, Hyatt, French, Christopher A., Peifer, Martin, Reinhardt, H. Christian, Örfi, László, Kéri, György, Ansén, Sascha, Heukamp, Lukas C., Büttner, Reinhard, Rauh, Daniel, Klebl, Bert M., Thomas, Roman K., Sos, Martin L.
Publicado 2017