Advances in Understanding Human Genetic Variations That Influence Innate Immunity to Fungi

por Merkhofer, Richard M., Klein, Bruce S.
Publicado 2020

Targeted Gene Disruption Reveals an Adhesin Indispensable for Pathogenicity of Blastomyces dermatitidis

por Tristan Brandhorst, T., Wüthrich, Marcel, Warner, Thomas, Klein, Bruce
Publicado 1999

Blastomyces Virulence Adhesin-1 Protein Binding to Glycosaminoglycans Is Enhanced by Protein Disulfide Isomerase

por Beaussart, Audrey, Brandhorst, Tristan, Dufrêne, Yves F., Klein, Bruce S.
Publicado 2015

Turning on virulence: Mechanisms that underpin the morphologic transition and pathogenicity of Blastomyces

por McBride, Joseph A., Gauthier, Gregory M., Klein, Bruce S.
Publicado 2018

Vaccine Immunity to Pathogenic Fungi Overcomes the Requirement for CD4 Help in Exogenous Antigen Presentation to CD8(+) T Cells: Implications for Vaccine Development in Immune-defi...

por Wüthrich, Marcel, Filutowicz, Hanna I., Warner, Tom, Deepe, George S., Klein, Bruce S.
Publicado 2003

Tc17 Cells Mediate Vaccine Immunity against Lethal Fungal Pneumonia in Immune Deficient Hosts Lacking CD4(+) T Cells

por Nanjappa, Som Gowda, Heninger, Erika, Wüthrich, Marcel, Gasper, David Joseph, Klein, Bruce S.
Publicado 2012

The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure

por Garfoot, Andrew L., Shen, Qian, Wüthrich, Marcel, Klein, Bruce S., Rappleye, Chad A.
Publicado 2016

Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1

por Walsh, Naomi M., Wuthrich, Marcel, Wang, Huafeng, Klein, Bruce, Hull, Christina M.
Publicado 2017

Identification and Characterization of Antifungal Compounds Using a Saccharomyces cerevisiae Reporter Bioassay

por Tebbets, Brad, Stewart, Douglas, Lawry, Stephanie, Nett, Jeniel, Nantel, Andre, Andes, David, Klein, Bruce S.
Publicado 2012

Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia

por Nanjappa, Som Gowda, Hernández-Santos, Nydiaris, Galles, Kevin, Wüthrich, Marcel, Suresh, M., Klein, Bruce S.
Publicado 2015

Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity

por Brandhorst, T. Tristan, Kean, Iain R. L., Lawry, Stephanie M., Wiesner, Darin L., Klein, Bruce S.
Publicado 2019

Fonsecaea pedrosoi‐induced Th17‐cell differentiation in mice is fostered by Dectin‐2 and suppressed by Mincle recognition

por Wüthrich, Marcel, Wang, Huafeng, Li, Mengyi, Lerksuthirat, Tassanee, Hardison, Sarah E., Brown, Gordon D., Klein, Bruce
Publicado 2015

BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens

por Contreras, Amanda, Wiesner, Darin L., Kingstad-Bakke, Brock, Lee, Woojong, Svaren, John P., Klein, Bruce S., Suresh, M.
Publicado 2022

Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis

por Xiong, Ye, Lingrel, Jerry B., Wüthrich, Marcel, Klein, Bruce S., Vasudevan, Neelakantan T., Jain, Mukesh K., George, Mariam, Deepe, George S.
Publicado 2016

Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells

por Nanjappa, Som Gowda, McDermott, Andrew J., Fites, J. Scott, Galles, Kevin, Wüthrich, Marcel, Deepe, George S., Klein, Bruce S.
Publicado 2017

O-Mannosylation of Proteins Enables Histoplasma Yeast Survival at Mammalian Body Temperatures

por Garfoot, Andrew L., Goughenour, Kristie D., Wüthrich, Marcel, Rajaram, Murugesan V. S., Schlesinger, Larry S., Klein, Bruce S., Rappleye, Chad A.
Publicado 2018

Characterization of antifungal C‐type lectin receptor expression on murine epithelial and endothelial cells in mucosal tissues

por Stappers, Mark H.T., Nikolakopoulou, Christina, Wiesner, Darin L., Yuecel, Raif, Klein, Bruce S., Willment, Janet A., Brown, Gordon D.
Publicado 2021

Distinctive populations of CD4(+)T cells associated with vaccine efficacy

por Woodring, Therese, Dewey, Colin N., Santos Dias, Lucas Dos, He, Xin, Dobson, Hannah E., Wüthrich, Marcel, Klein, Bruce
Publicado 2022

Complement Component 3C3 and C3a Receptor Are Required in Chitin-Dependent Allergic Sensitization to Aspergillus fumigatus but Dispensable in Chitin-Induced Innate Allergic Inflamm...

por Roy, René M., Paes, Hugo C., Nanjappa, Som G., Sorkness, Ron, Gasper, David, Sterkel, Alana, Wüthrich, Marcel, Klein, Bruce S.
Publicado 2013

CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis

por Kujoth, Gregory C., Sullivan, Thomas D., Merkhofer, Richard, Lee, Taek-Jin, Wang, Huafeng, Brandhorst, Tristan, Wüthrich, Marcel, Klein, Bruce S.
Publicado 2018