Modulating biomolecular condensates: a novel approach to drug discovery

por Mitrea, Diana M., Mittasch, Matthäus, Gomes, Beatriz Ferreira, Klein, Isaac A., Murcko, Mark A.
Publicado 2022

Principles and functions of condensate modifying drugs

por Patel, Avinash, Mitrea, Diana, Namasivayam, Vigneshwaran, Murcko, Mark A., Wagner, Michael, Klein, Isaac A.
Publicado 2022

Parallel Automated Flow Synthesis of Covalent Protein Complexes That Can Inhibit MYC-Driven Transcription

por Pomplun, Sebastian, Jbara, Muhammad, Schissel, Carly K., Wilson Hawken, Susana, Boija, Ann, Li, Charles, Klein, Isaac, Pentelute, Bradley L.
Publicado 2021

CD-CODE: crowdsourcing condensate database and encyclopedia

por Rostam, Nadia, Ghosh, Soumyadeep, Chow, Chi Fung Willis, Hadarovich, Anna, Landerer, Cedric, Ghosh, Rajat, Moon, HongKee, Hersemann, Lena, Mitrea, Diana M., Klein, Isaac A., Hyman, Anthony A., Toth-Petroczy, Agnes
Publicado 2023

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

por Santos, Margarida Almeida, Huen, Michael S.Y., Jankovic, Mila, Chen, Hua-Tang, López-Contreras, Andrés J., Klein, Isaac A., Wong, Nancy, Barbancho, Juan L.R., Fernandez-Capetillo, Oscar, Nussenzweig, Michel C., Chen, Junjie, Nussenzweig, André
Publicado 2010

Impact of Cancer History on Outcomes Among Hospitalized Patients with COVID‐19

por Klein, Isaac A., Rosenberg, Shoshana M., Reynolds, Kerry L., Zubiri, Leyre, Rosovsky, Rachel, Piper‐Vallillo, Andrew J., Gao, Xin, Boland, Genevieve, Bardia, Aditya, Gaither, Rachel, Freeman, Hannah, Kirkner, Gregory J., Rhee, Chanu, Klompas, Michael, Baker, Meghan A., Wadleigh, Martha, Winer, Eric P., Kotton, Camille N., Partridge, Ann H.
Publicado 2021

Predicting master transcription factors from pan-cancer expression data

por Reddy, Jessica, Fonseca, Marcos A. S., Corona, Rosario I., Nameki, Robbin, Segato Dezem, Felipe, Klein, Isaac A., Chang, Heidi, Chaves-Moreira, Daniele, Afeyan, Lena K., Malta, Tathiane M., Lin, Xianzhi, Abbasi, Forough, Font-Tello, Alba, Sabedot, Thais, Cejas, Paloma, Rodríguez-Malavé, Norma, Seo, Ji-Heui, Lin, De-Chen, Matulonis, Ursula, Karlan, Beth Y., Gayther, Simon A., Pasaniuc, Bogdan, Gusev, Alexander, Noushmehr, Houtan, Long, Henry, Freedman, Matthew L., Drapkin, Ronny, Young, Richard A., Abraham, Brian J., Lawrenson, Kate
Publicado 2021