Quantitative proteomics and terminomics to elucidate the role of ubiquitination and proteolysis in adaptive immunity

por Klein, Theo, Viner, Rosa I., Overall, Christopher M.
Publicado 2016

N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection

por Jagdeo, Julienne M., Dufour, Antoine, Klein, Theo, Solis, Nestor, Kleifeld, Oded, Kizhakkedathu, Jayachandran, Luo, Honglin, Overall, Christopher M., Jan, Eric
Publicado 2018

Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death

por Marshall, Natalie C., Thejoe, Maichael, Klein, Theo, Serapio-Palacios, Antonio, Santos, Andrew S., von Krosigk, Niklas, Kizhakkedathu, Jayachandran N., Stoynov, Nikolay, Foster, Leonard J., Overall, Christopher M., Finlay, B. Brett
Publicado 2020

C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease

por Dufour, Antoine, Bellac, Caroline L., Eckhard, Ulrich, Solis, Nestor, Klein, Theo, Kappelhoff, Reinhild, Fortelny, Nikolaus, Jobin, Parker, Rozmus, Jacob, Mark, Jennifer, Pavlidis, Paul, Dive, Vincent, Barbour, Sean J., Overall, Christopher M.
Publicado 2018

DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

por Tam, Vivian, Chen, Peikai, Yee, Anita, Solis, Nestor, Klein, Theo, Kudelko, Mateusz, Sharma, Rakesh, Chan, Wilson CW, Overall, Christopher M, Haglund, Lisbet, Sham, Pak C, Cheah, Kathryn Song Eng, Chan, Danny
Publicado 2020

MALT1-Dependent Cleavage of HOIL1 Modulates Canonical NF-κB Signaling and Inflammatory Responsiveness

por Fung, Shan-Yu, Lu, Henry Y., Sharma, Mehul, Sharma, Ashish A., Saferali, Aabida, Jia, Alicia, Abraham, Libin, Klein, Theo, Gold, Michael R., Noterangelo, Luigi D., Overall, Christopher M., Turvey, Stuart E.
Publicado 2021

Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension

por Cai, Zongye, Klein, Theo, Geenen, Laurie W., Tu, Ly, Tian, Siyu, van den Bosch, Annemien E., de Rijke, Yolanda B., Reiss, Irwin K. M., Boersma, Eric, Duncker, Dirk J., Boomars, Karin A., Guignabert, Christophe, Merkus, Daphne
Publicado 2020

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling

por Klein, Theo, Fung, Shan-Yu, Renner, Florian, Blank, Michael A., Dufour, Antoine, Kang, Sohyeong, Bolger-Munro, Madison, Scurll, Joshua M., Priatel, John J., Schweigler, Patrick, Melkko, Samu, Gold, Michael R., Viner, Rosa I., Régnier, Catherine H., Turvey, Stuart E., Overall, Christopher M.
Publicado 2015

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14

por Eckhard, Ulrich, Huesgen, Pitter F., Schilling, Oliver, Bellac, Caroline L., Butler, Georgina S., Cox, Jennifer H., Dufour, Antoine, Goebeler, Verena, Kappelhoff, Reinhild, auf dem Keller, Ulrich, Klein, Theo, Lange, Philipp F., Marino, Giada, Morrison, Charlotte J., Prudova, Anna, Rodriguez, David, Starr, Amanda E., Wang, Yili, Overall, Christopher M.
Publicado 2016

Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction

por Russo, Valerio, Klein, Theo, Lim, Darielle J., Solis, Nestor, Machado, Yoan, Hiroyasu, Sho, Nabai, Layla, Shen, Yue, Zeglinski, Matthew R., Zhao, Hongyan, Oram, Cameron P., Lennox, Peter A., Van Laeken, Nancy, Carr, Nick J., Crawford, Richard I., Franzke, Claus-Werner, Overall, Christopher M., Granville, David J.
Publicado 2018

Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging

por Moerman, Astrid M., Visscher, Mirjam, Slijkhuis, Nuria, Van Gaalen, Kim, Heijs, Bram, Klein, Theo, Burgers, Peter C., De Rijke, Yolanda B., Van Beusekom, Heleen M.M., Luider, Theo M., Verhagen, Hence J.M., Van der Steen, Antonius F.W., Gijsen, Frank J.H., Van der Heiden, Kim, Van Soest, Gijs
Publicado 2021

Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα

por Cai, Zongye, Tian, Siyu, Klein, Theo, Tu, Ly, Geenen, Laurie W., Koudstaal, Thomas, van den Bosch, Annemien E., de Rijke, Yolanda B., Reiss, Irwin K. M., Boersma, Eric, van der Ley, Claude, Van Faassen, Martijn, Kema, Ido, Duncker, Dirk J., Boomars, Karin A., Tran-Lundmark, Karin, Guignabert, Christophe, Merkus, Daphne
Publicado 2022

Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring

por Ghorasaini, Mohan, Mohammed, Yassene, Adamski, Jerzy, Bettcher, Lisa, Bowden, John A., Cabruja, Matias, Contrepois, Kévin, Ellenberger, Mathew, Gajera, Bharat, Haid, Mark, Hornburg, Daniel, Hunter, Christie, Jones, Christina M., Klein, Theo, Mayboroda, Oleg, Mirzaian, Mina, Moaddel, Ruin, Ferrucci, Luigi, Lovett, Jacqueline, Nazir, Kenneth, Pearson, Mackenzie, Ubhi, Baljit K., Raftery, Daniel, Riols, Fabien, Sayers, Rebekah, Sijbrands, Eric J. G., Snyder, Michael P., Su, Baolong, Velagapudi, Vidya, Williams, Kevin J., de Rijke, Yolanda B., Giera, Martin
Publicado 2021