The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

por Cline, Erika N., Bicca, Maíra Assunção, Viola, Kirsten L., Klein, William L.
Publicado 2018

Antibody Fragments as Tools for Elucidating Structure-Toxicity Relationships and for Diagnostic/Therapeutic Targeting of Neurotoxic Amyloid Oligomers

por Bitencourt, André L. B., Campos, Raquel M., Cline, Erika N., Klein, William L., Sebollela, Adriano
Publicado 2020

CCL2 Accelerates Microglia-Mediated Aβ Oligomer Formation and Progression of Neurocognitive Dysfunction

por Kiyota, Tomomi, Yamamoto, Masaru, Xiong, Huangui, Lambert, Mary P., Klein, William L., Gendelman, Howard E., Ransohoff, Richard M., Ikezu, Tsuneya
Publicado 2009

Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria

por Saraiva, Leonardo M., Seixas da Silva, Gisele S., Galina, Antonio, da-Silva, Wagner S., Klein, William L., Ferreira, Sérgio T., De Felice, Fernanda G.
Publicado 2010

Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain

por Welikovitch, Lindsay A., Do Carmo, Sonia, Maglóczky, Zsófia, Malcolm, Janice C., Lőke, János, Klein, William L., Freund, Tamás, Cuello, A. Claudio
Publicado 2020

Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease

por Ding, Yu, Zhao, Jiahui, Zhang, Xunle, Wang, Shanshan, Viola, Kirsten L., Chow, Frances E., Zhang, Yang, Lippa, Carol, Klein, William L., Gong, Yuesong
Publicado 2019

Diet‐induced Alzheimer's‐like syndrome in the rabbit

por Weiss, Craig, Bertolino, Nicola, Procissi, Daniele, Aleppo, Grazia, Smith, Quinn C., Viola, Kirsten L., Bartley, Samuel C., Klein, William L., Disterhoft, John F.
Publicado 2022

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study

por Iulita, M Florencia, Allard, Simon, Richter, Luise, Munter, Lisa-Marie, Ducatenzeiler, Adriana, Weise, Christoph, Do Carmo, Sonia, Klein, William L, Multhaup, Gerhard, Cuello, A Claudio
Publicado 2014

Elucidating Molecular Mass and Shape of a Neurotoxic Aβ Oligomer

por Sebollela, Adriano, Mustata, Gina-Mirela, Luo, Kevin, Velasco, Pauline T., Viola, Kirsten L., Cline, Erika N., Shekhawat, Gajendra S., Wilcox, Kyle C., Dravid, Vinayak P., Klein, William L.
Publicado 2014

Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer’s-Associated Aβ Oligomers

por Wilcox, Kyle C., Marunde, Matthew R., Das, Aditi, Velasco, Pauline T., Kuhns, Benjamin D., Marty, Michael T., Jiang, Haoming, Luan, Chi-Hao, Sligar, Stephen G., Klein, William L.
Publicado 2015

Aβ oligomer induced cognitive impairment and evaluation of ACU193‐MNS‐based MRI in rabbit

por Rozema, Nicholas B., Procissi, Daniele, Bertolino, Nicola, Viola, Kirsten L., Nandwana, Vikas, Abdul, Nafay, Pribus, Sophia, Dravid, Vinayak, Klein, William L., Disterhoft, John F., Weiss, Craig
Publicado 2020

Induction of inverted morphology in brain organoids by vertical-mixing bioreactors

por Suong, Dang Ngoc Anh, Imamura, Keiko, Inoue, Ikuyo, Kabai, Ryotaro, Sakamoto, Satoko, Okumura, Tatsuya, Kato, Yoshikazu, Kondo, Takayuki, Yada, Yuichiro, Klein, William L., Watanabe, Akira, Inoue, Haruhisa
Publicado 2021

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1

por Knight, Elysse M., Ruiz, Henry H., Kim, Soong Ho, Harte, Jessica C., Hsieh, Wilson, Glabe, Charles, Klein, William L., Attie, Alan D., Buettner, Christoph, Ehrlich, Michelle E., Gandy, Sam
Publicado 2016

Alzheimer’s Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station

por DiChiara, Thomas, DiNunno, Nadia, Clark, Jeffrey, Bu, Riana Lo, Cline, Erika N., Rollins, Madeline G., Gong, Yuesong, Brody, David L., Sligar, Stephen G., Velasco, Pauline T., Viola, Kirsten L., Klein, William L.
Publicado 2017

An Essential Role for Alzheimer’s-Linked Amyloid Beta Oligomers in Neurodevelopment: Transient Expression of Multiple Proteoforms during Retina Histogenesis

por Bartley, Samuel C., Proctor, Madison T., Xia, Hongjie, Ho, Evelyn, Kang, Dong S., Schuster, Kristen, Bicca, Maíra A., Seckler, Henrique S., Viola, Kirsten L., Patrie, Steven M., Kelleher, Neil L., De Mello, Fernando G., Klein, William L.
Publicado 2022

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology

por Haure-Mirande, Jean-Vianney, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Klein, William L., Glabe, Charles, Readhead, Ben, Dudley, Joel T., Blitzer, Robert D., Wang, Minghui, Zhang, Bin, Schadt, Eric E., Gandy, Sam, Ehrlich, Michelle E.
Publicado 2017

Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes

por Knight, Elysse M., Kim, Soong Ho, Kottwitz, Jessica C., Hatami, Asa, Albay, Ricardo, Suzuki, Akinobu, Lublin, Alex, Alberini, Cristina M., Klein, William L., Szabo, Paul, Relkin, Norman R., Ehrlich, Michelle, Glabe, Charles G., Gandy, Sam, Steele, John W.
Publicado 2016

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers

por Pitt, Jason, Wilcox, Kyle C., Tortelli, Vanessa, Diniz, Luan Pereira, Oliveira, Maira S., Dobbins, Cassandra, Yu, Xiao-Wen, Nandamuri, Sathwik, Gomes, Flávia C. A., DiNunno, Nadia, Viola, Kirsten L., De Felice, Fernanda G., Ferreira, Sergio T., Klein, William L.
Publicado 2017

The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer’s Disease

por Viola, Kirsten L., Bicca, Maira A., Bebenek, Adrian M., Kranz, Daniel L., Nandwana, Vikas, Waters, Emily A., Haney, Chad R., Lee, Maxwell, Gupta, Abhay, Brahmbhatt, Zachary, Huang, Weijian, Chang, Ting-Tung, Peck, Anderson, Valdez, Clarissa, Dravid, Vinayak P., Klein, William L.
Publicado 2022

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease

por Yang, Yun, Tapias, Victor, Acosta, Diana, Xu, Hui, Chen, Huanlian, Bhawal, Ruchika, Anderson, Elizabeth T., Ivanova, Elena, Lin, Hening, Sagdullaev, Botir T., Chen, Jianer, Klein, William L., Viola, Kirsten L., Gandy, Sam, Haroutunian, Vahram, Beal, M. Flint, Eliezer, David, Zhang, Sheng, Gibson, Gary E.
Publicado 2022