Functional characteristics of novel pancreatic Pax6 regulatory elements

por Buckle, Adam, Nozawa, Ryu-suke, Kleinjan, Dirk A, Gilbert, Nick
Publicado 2018

Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors

por Kleinjan, Dirk A., Wardrope, Caroline, Nga Sou, Si, Rosser, Susan J.
Publicado 2017

DNaseI Hypersensitivity and Ultraconservation Reveal Novel, Interdependent Long-Range Enhancers at the Complex Pax6 Cis-Regulatory Region

por McBride, David J., Buckle, Adam, van Heyningen, Veronica, Kleinjan, Dirk A.
Publicado 2011

The Developmental Regulator Pax6 Is Essential for Maintenance of Islet Cell Function in the Adult Mouse Pancreas

por Hart, Alan W., Mella, Sebastien, Mendrychowski, Jacek, van Heyningen, Veronica, Kleinjan, Dirk A.
Publicado 2013

Mosaic analysis of stem cell function and wound healing in the mouse corneal epithelium

por Mort, Richard L, Ramaesh, Thaya, Kleinjan, Dirk A, Morley, Steven D, West, John D
Publicado 2009

Identification of Genomic Regions Regulating Pax6 Expression in Embryonic Forebrain Using YAC Reporter Transgenic Mouse Lines

por Mi, Da, Huang, Yu-Ting, Kleinjan, Dirk A., Mason, John O., Price, David J.
Publicado 2013

Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver

por Ghiraldini, Flávia G, Silveira, André B, Kleinjan, Dirk A, Gilbert, Nick, Mello, Maria Luiza S
Publicado 2014

Lampreys, the jawless vertebrates, contain three Pax6 genes with distinct expression in eye, brain and pancreas

por Ravi, Vydianathan, Bhatia, Shipra, Shingate, Prashant, Tay, Boon-Hui, Venkatesh, Byrappa, Kleinjan, Dirk A.
Publicado 2019

Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse

por Tyas, David A, Simpson, T Ian, Carr, Catherine B, Kleinjan, Dirk A, van Heyningen, Veronica, Mason, John O, Price, David J
Publicado 2006

Long-range downstream enhancers are essential for Pax6 expression

por Kleinjan, Dirk A., Seawright, Anne, Mella, Sebastien, Carr, Catherine B., Tyas, David A., Simpson, T. Ian, Mason, John O., Price, David J., van Heyningen, Veronica
Publicado 2006

Functional Assessment of Disease-Associated Regulatory Variants In Vivo Using a Versatile Dual Colour Transgenesis Strategy in Zebrafish

por Bhatia, Shipra, Gordon, Christopher T., Foster, Robert G., Melin, Lucie, Abadie, Véronique, Baujat, Geneviève, Vazquez, Marie-Paule, Amiel, Jeanne, Lyonnet, Stanislas, van Heyningen, Veronica, Kleinjan, Dirk A.
Publicado 2015

Sequencing of Pax6 Loci from the Elephant Shark Reveals a Family of Pax6 Genes in Vertebrate Genomes, Forged by Ancient Duplications and Divergences

por Ravi, Vydianathan, Bhatia, Shipra, Gautier, Philippe, Loosli, Felix, Tay, Boon-Hui, Tay, Alice, Murdoch, Emma, Coutinho, Pedro, van Heyningen, Veronica, Brenner, Sydney, Venkatesh, Byrappa, Kleinjan, Dirk A.
Publicado 2013

Subfunctionalization of Duplicated Zebrafish pax6 Genes by cis-Regulatory Divergence

por Kleinjan, Dirk A, Bancewicz, Ruth M, Gautier, Philippe, Dahm, Ralf, Schonthaler, Helia B, Damante, Giuseppe, Seawright, Anne, Hever, Ann M, Yeyati, Patricia L, van Heyningen, Veronica, Coutinho, Pedro
Publicado 2008

Remotely acting SMCHD1 gene regulatory elements: in silico prediction and identification of potential regulatory variants in patients with FSHD

por Mayes, Mary B., Morgan, Taniesha, Winston, Jincy, Buxton, Daniel S., Kamat, Mihir Anant, Smith, Debbie, Williams, Maggie, Martin, Rebecca L., Kleinjan, Dirk A., Cooper, David N., Upadhyaya, Meena, Chuzhanova, Nadia
Publicado 2015

Disruption of SATB2 or its long-range cis-regulation by SOX9 causes a syndromic form of Pierre Robin sequence

por Rainger, Jacqueline K., Bhatia, Shipra, Bengani, Hemant, Gautier, Philippe, Rainger, Joe, Pearson, Matt, Ansari, Morad, Crow, Jayne, Mehendale, Felicity, Palinkasova, Bozena, Dixon, Michael J., Thompson, Pamela J., Matarin, Mar, Sisodiya, Sanjay M., Kleinjan, Dirk A., FitzPatrick, David R.
Publicado 2014