Dose and Time Dependencies in Stress Pathway Responses during Chemical Exposure: Novel Insights from Gene Regulatory Networks

por Souza, Terezinha M., Kleinjans, Jos C. S., Jennen, Danyel G. J.
Publicado 2017

Moving Forward in Human Cancer Risk Assessment

por Paules, Richard S., Aubrecht, Jiri, Corvi, Raffaella, Garthoff, Bernward, Kleinjans, Jos C.
Publicado 2011

Workshop report: Identifying opportunities for global integration of toxicogenomics databases, 26–27 June 2013, Research Triangle Park, NC, USA

por Hendrickx, Diana M., Boyles, Rebecca R., Kleinjans, Jos C. S., Dearry, Allen
Publicado 2014

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds

por Hendrickx, Diana M., Souza, Terezinha, Jennen, Danyel G. J., Kleinjans, Jos C. S.
Publicado 2016

Rationale for Environmental Hygiene towards global protection of fetuses and young children from adverse lifestyle factors

por Bourguignon, Jean-Pierre, Parent, Anne-Simone, Kleinjans, Jos C. S., Nawrot, Tim S., Schoeters, Greet, Van Larebeke, Nicolas
Publicado 2018

Nitrate Intake Does Not Influence Bladder Cancer Risk: The Netherlands Cohort Study

por Zeegers, Maurice P., Selen, Roel F.M., Kleinjans, Jos C.S., Goldbohm, R. Alexandra, van den Brandt, Piet A.
Publicado 2006

Comparison of statistical methods and the use of quality control samples for batch effect correction in human transcriptome data

por Espín-Pérez, Almudena, Portier, Chris, Chadeau-Hyam, Marc, van Veldhoven, Karin, Kleinjans, Jos C. S., de Kok, Theo M. C. M.
Publicado 2018

Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease

por Bohler, Sacha, Liu, Xiaosong, Krauskopf, Julian, Caiment, Florian, Aubrecht, Jiri, Nicolaes, Gerry A. F., Kleinjans, Jos C. S., Briedé, Jacco J.
Publicado 2019

Blood Transcriptome Response to Environmental Metal Exposure Reveals Potential Biological Processes Related to Alzheimer's Disease

por Krauskopf, Julian, Bergdahl, Ingvar A., Johansson, Anders, Palli, Domenico, Lundh, Thomas, Kyrtopoulos, Soterios A., de Kok, Theo M., Kleinjans, Jos C.
Publicado 2020

Small RNA Sequencing of Aqueous Humor and Plasma in Patients With Primary Open-Angle Glaucoma

por Hubens, Wouter H. G., Krauskopf, Julian, Beckers, Henny J. M., Kleinjans, Jos C. S., Webers, Carroll A. B., Gorgels, Theo G. M. F.
Publicado 2021

Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes

por Wolters, Jarno E. J., van Breda, Simone G. J., Caiment, Florian, Claessen, Sandra M., de Kok, Theo M. C. M., Kleinjans, Jos C. S.
Publicado 2017

Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response

por Jennen, Danyel G. J., van Herwijnen, Marcel, Jetten, Marlon, Vandebriel, Rob J., Keizers, Peter, Geertsma, Robert E., de Jong, Wim H., Kleinjans, Jos C. S.
Publicado 2022

MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery

por Krauskopf, Julian, de Kok, Theo M., Hebels, Dennie G., Bergdahl, Ingvar A., Johansson, Anders, Spaeth, Florentin, Kiviranta, Hannu, Rantakokko, Panu, Kyrtopoulos, Soterios A., Kleinjans, Jos C.
Publicado 2017

Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids

por Rodrigues, Daniela, Coyle, Luke, Füzi, Barbara, Ferreira, Sofia, Jo, Heeseung, Herpers, Bram, Chung, Seung-Wook, Fisher, Ciarán, Kleinjans, Jos C. S., Jennen, Danyel, de Kok, Theo M.
Publicado 2022

A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids

por Rodrigues, Daniela, Herpers, Bram, Ferreira, Sofia, Jo, Heeseung, Fisher, Ciarán, Coyle, Luke, Chung, Seung-Wook, Kleinjans, Jos C. S., Jennen, Danyel G. J., de Kok, Theo M.
Publicado 2022

Transcriptome Analysis in Peripheral Blood of Humans Exposed to Environmental Carcinogens: A Promising New Biomarker in Environmental Health Studies

por van Leeuwen, Danitsja M., Gottschalk, Ralph W.H., Schoeters, Greet, van Larebeke, Nicolas A., Nelen, Vera, Baeyens, Willy F., Kleinjans, Jos C.S., van Delft, Joost H.M.
Publicado 2008

Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

por Hettne, Kristina M, Boorsma, André, van Dartel, Dorien A M, Goeman, Jelle J, de Jong, Esther, Piersma, Aldert H, Stierum, Rob H, Kleinjans, Jos C, Kors, Jan A
Publicado 2013

Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human

por Krauskopf, Julian, de Kok, Theo M., Schomaker, Shelli J., Gosink, Mark, Burt, Deborah A., Chandler, Patricia, Warner, Roscoe L., Johnson, Kent J., Caiment, Florian, Kleinjans, Jos C., Aubrecht, Jiri
Publicado 2017

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes

por Jetten, Marlon J. A., Ruiz-Aracama, Ainhoa, Coonen, Maarten L. J., Claessen, Sandra M., van Herwijnen, Marcel H. M., Lommen, Arjen, van Delft, Joost H. M., Peijnenburg, Ad A. C. M., Kleinjans, Jos C. S.
Publicado 2015

Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability

por Chandrasekaran, Vidya, Carta, Giada, da Costa Pereira, Daniel, Gupta, Rajinder, Murphy, Cormac, Feifel, Elisabeth, Kern, Georg, Lechner, Judith, Cavallo, Anna Lina, Gupta, Shailesh, Caiment, Florian, Kleinjans, Jos C. S., Gstraunthaler, Gerhard, Jennings, Paul, Wilmes, Anja
Publicado 2021