C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells

por Klempnauer, Karl-Heinz
Publicado 2023

Natural Products with Antitumor Potential Targeting the MYB-C/EBPβ-p300 Transcription Module

por Schmidt, Thomas J., Klempnauer, Karl-Heinz
Publicado 2022

The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication

por Gundelach, Holger, Braas, Daniel, Klempnauer, Karl-Heinz
Publicado 2007

Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene

por Ivanova, Olga, Braas, Daniel, Klempnauer, Karl-Heinz
Publicado 2007

Translation, Pdcd4 and eIF4A

por Biyanee, Abhiruchi, Singh, Priyanka, Klempnauer, Karl-Heinz
Publicado 2015

A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity

por Yusenko, Maria, Jakobs, Anke, Klempnauer, Karl-Heinz
Publicado 2018

Src-Family Protein Kinase Inhibitors Suppress MYB Activity in a p300-Dependent Manner

por Biyanee, Abhiruchi, Yusenko, Maria V., Klempnauer, Karl-Heinz
Publicado 2022

Activation of the oncogenic transcription factor B-Myb via multisite phosphorylation and prolyl cis/trans isomerization

por Werwein, Eugen, Cibis, Hannah, Hess, Daniel, Klempnauer, Karl-Heinz
Publicado 2019

PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs

por Haas, Astrid, Nilges, Benedikt S., Leidel, Sebastian A., Klempnauer, Karl-Heinz
Publicado 2020

Characterization of the zinc finger proteins ZMYM2 and ZMYM4 as novel B-MYB binding proteins

por Cibis, Hannah, Biyanee, Abhiruchi, Dörner, Wolfgang, Mootz, Henning D., Klempnauer, Karl-Heinz
Publicado 2020

The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression

por Coulibaly, Anna, Haas, Astrid, Steinmann, Simone, Jakobs, Anke, Schmidt, Thomas J., Klempnauer, Karl-Heinz
Publicado 2018

An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4

por Fehler, Olesja, Singh, Priyanka, Haas, Astrid, Ulrich, Diana, Müller, Jan P., Ohnheiser, Johanna, Klempnauer, Karl-Heinz
Publicado 2014

Multimodal 4-arylchromene derivatives with microtubule-destabilizing, anti-angiogenic, and MYB-inhibitory activities

por Köhler, Leonhard H. F., Reich, Sebastian, Yusenko, Maria, Klempnauer, Karl-Heinz, Begemann, Gerrit, Schobert, Rainer, Biersack, Bernhard
Publicado 2023

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling

por Henrich, Sarah Marie, Usadel, Clemens, Werwein, Eugen, Burdova, Kamila, Janscak, Pavel, Ferrari, Stefano, Hess, Daniel, Klempnauer, Karl-Heinz
Publicado 2017

Resonance assignment and secondary structure of the middle MA-3 domain and complete tandem MA-3 region of the tumour suppressor protein Pdcd4

por Waters, Lorna C., Oka, Ojore, Muskett, Frederick W., Strong, Sarah L., Schmedt, Thore, Klempnauer, Karl-Heinz, Carr, Mark D.
Publicado 2009

PRMT4 Is a Novel Coactivator of c-Myb-Dependent Transcription in Haematopoietic Cell Lines

por Streubel, Gundula, Bouchard, Caroline, Berberich, Hannah, Zeller, Marc S., Teichmann, Sophia, Adamkiewicz, Jürgen, Müller, Rolf, Klempnauer, Karl-Heinz, Bauer, Uta-Maria
Publicado 2013

Interaction of the Transactivation Domain of B-Myb with the TAZ2 Domain of the Coactivator p300: Molecular Features and Properties of the Complex

por Oka, Ojore, Waters, Lorna C., Strong, Sarah L., Dosanjh, Nuvjeevan S., Veverka, Vaclav, Muskett, Frederick W., Renshaw, Philip S., Klempnauer, Karl-Heinz, Carr, Mark D.
Publicado 2012

Bcr-TMP, a Novel Nanomolar-Active Compound That Exhibits Both MYB- and Microtubule-Inhibitory Activity

por Yusenko, Maria V., Biyanee, Abhiruchi, Frank, Daria, Köhler, Leonhard H. F., Andersson, Mattias K., Khandanpour, Cyrus, Schobert, Rainer, Stenman, Göran, Biersack, Bernhard, Klempnauer, Karl-Heinz
Publicado 2021

Structure of the Tandem MA-3 Region of Pdcd4 Protein and Characterization of Its Interactions with eIF4A and eIF4G: MOLECULAR MECHANISMS OF A TUMOR SUPPRESSOR

por Waters, Lorna C., Strong, Sarah L., Ferlemann, Eva, Oka, Ojore, Muskett, Frederick W., Veverka, Vaclav, Banerjee, Sreemoti, Schmedt, Thore, Henry, Alistair J., Klempnauer, Karl-Heinz, Carr, Mark D.
Publicado 2011

C/EBPβ is a MYB- and p300-cooperating pro-leukemogenic factor and promising drug target in acute myeloid leukemia

por Yusenko, Maria V., Trentmann, Amke, Casolari, Debora A., Abdel Ghani, Luca, Lenz, Mairin, Horn, Melanie, Dörner, Wolfgang, Klempnauer, Stefan, Mootz, Henning D., Arteaga, Maria Francisca, Mikesch, Jan-Henrik, D’Andrea, Richard J., Gonda, Thomas J., Müller-Tidow, Carsten, Schmidt, Thomas J., Klempnauer, Karl-Heinz
Publicado 2021