P458: HIPSC DISEASE MODELING TO STUDY LEUKEMIA DEVELOPMENT IN HAX1 VS ELANE ASSOCIATED CONGENITAL NEUTROPENIA

por Dannenmann, Benjamin, Klimiankou, Maksim, Zeidler, Cornelia, Welte, Karl, Skokowa, Julia
Publicado 2023

Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche

por Borbaran-Bravo, Natalia, Arreba-Tutusaus, Patricia, Ritter, Malte U., Nasri, Masoud, Klimiankou, Maksim, Skokowa, Julia
Publicado 2022

Ultra-Sensitive CSF3R Deep Sequencing in Patients With Severe Congenital Neutropenia

por Klimiankou, Maksim, Uenalan, Murat, Kandabarau, Siarhei, Nustede, Rainer, Steiert, Ingeborg, Mellor-Heineke, Sabine, Zeidler, Cornelia, Skokowa, Julia, Welte, Karl
Publicado 2019

Cooperating, congenital neutropenia–associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs

por Ritter, Malte, Klimiankou, Maksim, Klimenkova, Olga, Schambach, Axel, Hoffmann, Dirk, Schmidt, Amy, Kanz, Lothar, Link, Daniel C., Welte, Karl, Skokowa, Julia
Publicado 2020

P751: UNRAVELING THE DIFFERENT PATHOMECHANISMS OF CONGENITAL AND CYCLIC NEUTROPENIAS: CYCLIC EXPRESSION OF HEMATOPOIETIC STEM-CELL-SPECIFIC TRANSCRIPTION FACTORS IN CYCLIC NEUTROPE...

por Alexander Zeidler, Karl, Borbaran-Bravo, Natalia, Ritter, Malte, Nasri, Masoud, Klimiankou, Maksim, Kandabarau, Sergey, König, Josef, Zeidler, Cornelia, Skokowa, Julia, Welte, Karl
Publicado 2023

S178: A NEW HEREDITARY SYNDROME WITH SEVERE NEUTROPENIA AND NEUROLOGICAL INVOLVEMENT CAUSED BY THE AUTOSOMAL RECESSIVE COPZ1 MUTATION

por Borbaran Bravo, Natalia, Doll, Larissa, Deordieva, Ekaterina, Bräuning, Sandro, Dannenmann, Benjamin, Elgamacy, Mohammad, Zakharova, Viktoria, Lengerke, Claudia, Zeidler, Cornelia, Welte, Karl, Shcherbina, Anna, Skokowa, Julia, Klimiankou, Maksim
Publicado 2023

P1357: MILESTONE (MODIFYING ELANE GOLDBERG–HOGNES BOX TO INHIBIT EXPRESSION), A UNIVERSAL, SAFE AND EFFECTIVE CRISPR/CAS9N-MEDIATED GENOME EDITING STRATEGY FOR ELANE RELATED SEVERE...

por Nasri, Masoud, Ulrich Ritter, Malte, Mir, Perihan, Dannenmann, Benjamin, Monika Kaufmann, Masako, Xu, Yun, Borbaran-Bravo, Natalia, Klimiankou, Maksim, Lengerke, Claudia, Zeidler, Cornelia, Cathomen, Toni, Welte, Karl, Skokowa, Julia
Publicado 2023

P779: LONG-TERM COURSE OF HAX1-RELATED CONGENITAL NEUTROPENIA: AN ANALYSIS OF THE EUROPEAN SEVERE CHRONIC NEUTROPENIA INTERNATIONAL REGISTRY (SCNIR)

por Pogozhykh, Denys, Yilmaz Karapinar, Deniz, Klimiankou, Maksim, Gerschmann, Natali, Ebetsberger-Dachs, Georg, Palmblad, Jan, Carlsson, Göran, Masmas, Tania, Kinsey, Sally, Bartels, Marije, Mellor-Heineke, Sabine, Welte, Karl, Skokowa, Julia, Zeidler, Cornelia
Publicado 2023

CRISPR/Cas9-mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutr...

por Nasri, Masoud, Ritter, Malte, Mir, Perihan, Dannenmann, Benjamin, Aghaallaei, Narges, Amend, Diana, Makaryan, Vahagn, Xu, Yun, Fletcher, Breanna, Bernhard, Regine, Steiert, Ingeborg, Hahnel, Karin, Berger, Jürgen, Koch, Iris, Sailer, Brigitte, Hipp, Katharina, Zeidler, Cornelia, Klimiankou, Maksim, Bajoghli, Baubak, Dale, David C., Welte, Karl, Skokowa, Julia
Publicado 2020