Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function

por Ferrer, Pedro Eitz, Frederick, Paul, Gulbis, Jacqueline M., Dewson, Grant, Kluck, Ruth M.
Publicado 2012

Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release

por von Ahsen, Oliver, Renken, Christian, Perkins, Guy, Kluck, Ruth M., Bossy-Wetzel, Ella, Newmeyer, Donald D.
Publicado 2000

Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs

por Diepstraten, Sarah T., Young, Savannah, La Marca, John E., Wang, Zilu, Kluck, Ruth M., Strasser, Andreas, Kelly, Gemma L.
Publicado 2023

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

por Uren, Rachel T., Dewson, Grant, Chen, Lin, Coyne, Stephanie C., Huang, David C.S., Adams, Jerry M., Kluck, Ruth M.
Publicado 2007

NAb-seq: an accurate, rapid, and cost-effective method for antibody long-read sequencing in hybridoma cell lines and single B cells

por Subas Satish, Hema Preethi, Zeglinski, Kathleen, Uren, Rachel T., Nutt, Stephen L., Ritchie, Matthew E., Gouil, Quentin, Kluck, Ruth M.
Publicado 2022

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

por Iyer, Sweta, Uren, Rachel T., Dengler, Michael A., Shi, Melissa X., Uno, Etsuko, Adams, Jerry M., Dewson, Grant, Kluck, Ruth M.
Publicado 2020

MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication

por Fleming, Peter, Kvansakul, Marc, Voigt, Valentina, Kile, Benjamin T., Kluck, Ruth M., Huang, David C. S., Degli-Esposti, Mariapia A., Andoniou, Christopher E.
Publicado 2013

Disordered clusters of Bak dimers rupture mitochondria during apoptosis

por Uren, Rachel T, O’Hely, Martin, Iyer, Sweta, Bartolo, Ray, Shi, Melissa X, Brouwer, Jason M, Alsop, Amber E, Dewson, Grant, Kluck, Ruth M
Publicado 2017

A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity

por Yeo, Janet H. C., Skinner, Jarrod P. J., Bird, Matthew J., Formosa, Luke E., Zhang, Jian-Guo, Kluck, Ruth M., Belz, Gabrielle T., Chong, Mark M. W.
Publicado 2015

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

por Iyer, Sweta, Anwari, Khatira, Alsop, Amber E., Yuen, Wai Shan, Huang, David C. S., Carroll, John, Smith, Nicholas A., Smith, Brian J., Dewson, Grant, Kluck, Ruth M.
Publicado 2016

The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

por Kluck, Ruth M., Esposti, Mauro Degli, Perkins, Guy, Renken, Christian, Kuwana, Tomomi, Bossy-Wetzel, Ella, Goldberg, Martin, Allen, Terry, Barber, Michael J., Green, Douglas R., Newmeyer, Donald D.
Publicado 1999

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

por Slee, Elizabeth A., Harte, Mary T., Kluck, Ruth M., Wolf, Beni B., Casiano, Carlos A., Newmeyer, Donald D., Wang, Hong-Gang, Reed, John C., Nicholson, Donald W., Alnemri, Emad S., Green, Douglas R., Martin, Seamus J.
Publicado 1999

Physiological restraint of Bak by Bcl-x(L) is essential for cell survival

por Lee, Erinna F., Grabow, Stephanie, Chappaz, Stephane, Dewson, Grant, Hockings, Colin, Kluck, Ruth M., Debrincat, Marlyse A., Gray, Daniel H., Witkowski, Matthew T., Evangelista, Marco, Pettikiriarachchi, Anne, Bouillet, Philippe, Lane, Rachael M., Czabotar, Peter E., Colman, Peter M., Smith, Brian J., Kile, Benjamin T., Fairlie, W. Douglas
Publicado 2016

VDAC2 enables BAX to mediate apoptosis and limit tumor development

por Chin, Hui San, Li, Mark X., Tan, Iris K. L., Ninnis, Robert L., Reljic, Boris, Scicluna, Kristen, Dagley, Laura F., Sandow, Jarrod J., Kelly, Gemma L., Samson, Andre L., Chappaz, Stephane, Khaw, Seong L., Chang, Catherine, Morokoff, Andrew, Brinkmann, Kerstin, Webb, Andrew, Hockings, Colin, Hall, Cathrine M., Kueh, Andrew J., Ryan, Michael T., Kluck, Ruth M., Bouillet, Philippe, Herold, Marco J., Gray, Daniel H. D., Huang, David C. S., van Delft, Mark F., Dewson, Grant
Publicado 2018