Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma

por Knatko, Elena V., Higgins, Maureen, Fahey, Jed W., Dinkova-Kostova, Albena T.
Publicado 2016

Functional mapping of the fission yeast DNA polymerase δ B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis

por Sanchez Garcia, Javier, Baranovskiy, Andrey G, Knatko, Elena V, Gray, Fiona C, Tahirov, Tahir H, MacNeill, Stuart A
Publicado 2009

Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma

por Roth, Kevin, Coussement, Louis, Knatko, Elena V., Higgins, Maureen, Steyaert, Sandra, Proby, Charlotte M., de Meyer, Tim, Dinkova-Kostova, Albena T.
Publicado 2021

Pirin, an Nrf2-Regulated Protein, Is Overexpressed in Human Colorectal Tumors

por Zhang, Ying, Knatko, Elena V., Higgins, Maureen, Dayalan Naidu, Sharadha, Smith, Gillian, Honda, Tadashi, de la Vega, Laureano, Dinkova-Kostova, Albena T.
Publicado 2022

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

por Kostov, Rumen V., Knatko, Elena V., McLaughlin, Lesley A., Henderson, Colin J., Zheng, Suqing, Huang, Jeffrey T.-J., Honda, Tadashi, Dinkova-Kostova, Albena T.
Publicado 2015

Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer

por Knatko, Elena V., Castro, Cecilia, Higgins, Maureen, Zhang, Ying, Honda, Tadashi, Henderson, Colin J., Wolf, C. Roland, Griffin, Julian L., Dinkova-Kostova, Albena T.
Publicado 2021

The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2

por Dayalan Naidu, Sharadha, Suzuki, Takafumi, Dikovskaya, Dina, Knatko, Elena V., Higgins, Maureen, Sato, Miu, Novak, Miroslav, Villegas, José A., Moore, Terry W., Yamamoto, Masayuki, Dinkova-Kostova, Albena T.
Publicado 2021

Downregulation of Keap1 Confers Features of a Fasted Metabolic State

por Knatko, Elena V., Tatham, Michael H., Zhang, Ying, Castro, Cecilia, Higgins, Maureen, Dayalan Naidu, Sharadha, Leonardi, Chiara, de la Vega, Laureano, Honda, Tadashi, Griffin, Julian L., Hay, Ronald T., Dinkova-Kostova, Albena T.
Publicado 2020

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

por Dayalan Naidu, Sharadha, Dikovskaya, Dina, Gaurilcikaite, Egle, Knatko, Elena V., Healy, Zachary R., Mohan, Hema, Koh, Glenn, Laurell, Axel, Ball, Graeme, Olagnier, David, de la Vega, Laureano, Ganley, Ian G., Talalay, Paul, Dinkova-Kostova, Albena T.
Publicado 2017

Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

por Olagnier, David, Lababidi, Rassin R., Hadj, Samar Bel, Sze, Alexandre, Liu, Yiliu, Naidu, Sharadha Dayalan, Ferrari, Matteo, Jiang, Yuan, Chiang, Cindy, Beljanski, Vladimir, Goulet, Marie-Line, Knatko, Elena V., Dinkova-Kostova, Albena T., Hiscott, John, Lin, Rongtuan
Publicado 2017

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

por Ryan, Dylan G., Knatko, Elena V., Casey, Alva M., Hukelmann, Jens L., Dayalan Naidu, Sharadha, Brenes, Alejandro J., Ekkunagul, Thanapon, Baker, Christa, Higgins, Maureen, Tronci, Laura, Nikitopolou, Efterpi, Honda, Tadashi, Hartley, Richard C., O’Neill, Luke A.J., Frezza, Christian, Lamond, Angus I., Abramov, Andrey Y., Arthur, J. Simon C., Cantrell, Doreen A., Murphy, Michael P., Dinkova-Kostova, Albena T.
Publicado 2022