A comprehensive assessment of RNA-seq protocols for degraded and low-quantity samples

por Schuierer, Sven, Carbone, Walter, Knehr, Judith, Petitjean, Virginie, Fernandez, Anita, Sultan, Marc, Roma, Guglielmo
Publicado 2017

A single cell atlas of the tracheal epithelium reveals the CFTR-rich pulmonary ionocyte

por Plasschaert, Lindsey W., Žilionis, Rapolas, Choo-Wing, Rayman, Savova, Virginia, Knehr, Judith, Roma, Guglielmo, Klein, Allon M., Jaffe, Aron B.
Publicado 2018

MiR-210 promotes sensory hair cell formation in the organ of corti

por Riccardi, Sabrina, Bergling, Sebastian, Sigoillot, Frederic, Beibel, Martin, Werner, Annick, Leighton-Davies, Juliet, Knehr, Judith, Bouwmeester, Tewis, Parker, Christian N., Roma, Guglielmo, Kinzel, Bernd
Publicado 2016

A Simple and Efficient CRISPR Technique for Protein Tagging

por Zeng, Fanning, Beck, Valerie, Schuierer, Sven, Garnier, Isabelle, Manneville, Carole, Agarinis, Claudia, Morelli, Lapo, Quinn, Lisa, Knehr, Judith, Roma, Guglielmo, Bassilana, Frederic, Nash, Mark
Publicado 2020

Identification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screening

por Kiessling, Michael K., Schuierer, Sven, Stertz, Silke, Beibel, Martin, Bergling, Sebastian, Knehr, Judith, Carbone, Walter, de Vallière, Cheryl, Tchinda, Joelle, Bouwmeester, Tewis, Seuwen, Klaus, Rogler, Gerhard, Roma, Guglielmo
Publicado 2016

Farnesoid X Receptor Agonism, Acetyl‐Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model

por Gapp, Berangere, Jourdain, Marie, Bringer, Pauline, Kueng, Benjamin, Weber, Delphine, Osmont, Arnaud, Zurbruegg, Stefan, Knehr, Judith, Falchetto, Rocco, Roma, Guglielmo, Dietrich, William, Valdez, Reginald, Beckmann, Nicolau, Nigsch, Florian, Sanyal, Arun J., Ksiazek, Iwona
Publicado 2019

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

por Wang, Zhong-Yi, Keogh, Adrian, Waldt, Annick, Cuttat, Rachel, Neri, Marilisa, Zhu, Shanshan, Schuierer, Sven, Ruchti, Alexandra, Crochemore, Christophe, Knehr, Judith, Bastien, Julie, Ksiazek, Iwona, Sánchez-Taltavull, Daniel, Ge, Hui, Wu, Jing, Roma, Guglielmo, Helliwell, Stephen B., Stroka, Deborah, Nigsch, Florian
Publicado 2021

PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

por Bleu, Melusine, Gaulis, Swann, Lopes, Rui, Sprouffske, Kathleen, Apfel, Verena, Holwerda, Sjoerd, Pregnolato, Marco, Yildiz, Umut, Cordoʹ, Valentina, Dost, Antonella F. M., Knehr, Judith, Carbone, Walter, Lohmann, Felix, Lin, Charles Y., Bradner, James E., Kauffmann, Audrey, Tordella, Luca, Roma, Guglielmo, Galli, Giorgio G.
Publicado 2019

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy

por Potting, Christoph, Crochemore, Christophe, Moretti, Francesca, Nigsch, Florian, Schmidt, Isabel, Manneville, Carole, Carbone, Walter, Knehr, Judith, DeJesus, Rowena, Lindeman, Alicia, Maher, Rob, Russ, Carsten, McAllister, Gregory, Reece-Hoyes, John S., Hoffman, Gregory R., Roma, Guglielmo, Müller, Matthias, Sailer, Andreas W., Helliwell, Stephen B.
Publicado 2018

Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens

por Barbosa, Inês A. M., Gopalakrishnan, Rajaraman, Mercan, Samuele, Mourikis, Thanos P., Martin, Typhaine, Wengert, Simon, Sheng, Caibin, Ji, Fei, Lopes, Rui, Knehr, Judith, Altorfer, Marc, Lindeman, Alicia, Russ, Carsten, Naumann, Ulrike, Golji, Javad, Sprouffske, Kathleen, Barys, Louise, Tordella, Luca, Schübeler, Dirk, Schmelzle, Tobias, Galli, Giorgio G.
Publicado 2023

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion

por Keller, Caroline Gubser, Shin, Youngah, Monteys, Alex Mas, Renaud, Nicole, Beibel, Martin, Teider, Natalia, Peters, Thomas, Faller, Thomas, St-Cyr, Sophie, Knehr, Judith, Roma, Guglielmo, Reyes, Alejandro, Hild, Marc, Lukashev, Dmitriy, Theil, Diethilde, Dales, Natalie, Cha, Jang-Ho, Borowsky, Beth, Dolmetsch, Ricardo, Davidson, Beverly L., Sivasankaran, Rajeev
Publicado 2022

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

por Voorberg-van der Wel, Annemarie, Roma, Guglielmo, Gupta, Devendra Kumar, Schuierer, Sven, Nigsch, Florian, Carbone, Walter, Zeeman, Anne-Marie, Lee, Boon Heng, Hofman, Sam O, Faber, Bart W, Knehr, Judith, Pasini, Erica, Kinzel, Bernd, Bifani, Pablo, Bonamy, Ghislain M C, Bouwmeester, Tewis, Kocken, Clemens H M, Diagana, Thierry Tidiane
Publicado 2017

STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia

por Morozzi, Giulio, Rothen, Julian, Toussaint, Gauthier, De Lange, Katrina, Westritschnig, Katrin, Doelemeyer, Arno, Ueberschlag, Vanessa Pitiot, Kahle, Peter, Lambert, Christian, Obrecht, Michael, Beckmann, Nicolau, Ritter, Veronique, Panesar, Moh, Stauffer, Daniela, Garnier, Isabelle, Mueller, Matthias, Guerini, Danilo, Keller, Caroline Gubser, Knehr, Judith, Roma, Guglielmo, Bidinosti, Michael, Brachat, Sophie, Morvan, Frederic, Fornaro, Mara
Publicado 2021

An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells

por Kobylarz, Marek J., Goodwin, Jonathan M., Kang, Zhao B., Annand, John W., Hevi, Sarah, O’Mahony, Ellen, McAllister, Gregory, Reece-Hoyes, John, Wang, Qiong, Alford, John, Russ, Carsten, Lindeman, Alicia, Beibel, Martin, Roma, Guglielmo, Carbone, Walter, Knehr, Judith, Loureiro, Joseph, Antczak, Christophe, Wiederschain, Dmitri, Murphy, Leon O., Menon, Suchithra, Nyfeler, Beat
Publicado 2020

The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice

por Tuominen, Iina, Fuqua, Brie K., Pan, Calvin, Renaud, Nicole, Wroblewski, Kevin, Civelek, Mete, Clerkin, Kara, Asaryan, Ashot, Haroutunian, Sara G., Loureiro, Joseph, Borawski, Jason, Roma, Guglielmo, Knehr, Judith, Carbone, Walter, French, Samuel, Parks, Brian W., Hui, Simon T., Mehrabian, Margarete, Magyar, Clara, Cantor, Rita M., Ukomadu, Chinweike, Lusis, Aldons J., Beaven, Simon W.
Publicado 2020

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62

por DeJesus, Rowena, Moretti, Francesca, McAllister, Gregory, Wang, Zuncai, Bergman, Phil, Liu, Shanming, Frias, Elizabeth, Alford, John, Reece-Hoyes, John S, Lindeman, Alicia, Kelliher, Jennifer, Russ, Carsten, Knehr, Judith, Carbone, Walter, Beibel, Martin, Roma, Guglielmo, Ng, Aylwin, Tallarico, John A, Porter, Jeffery A, Xavier, Ramnik J, Mickanin, Craig, Murphy, Leon O, Hoffman, Gregory R, Nyfeler, Beat
Publicado 2016

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells

por Estoppey, David, Hewett, Jeffrey W., Guy, Chantale T., Harrington, Edmund, Thomas, Jason R., Schirle, Markus, Cuttat, Rachel, Waldt, Annick, Gerrits, Bertran, Yang, Zinger, Schuierer, Sven, Pan, Xuewen, Xie, Kevin, Carbone, Walter, Knehr, Judith, Lindeman, Alicia, Russ, Carsten, Frias, Elizabeth, Hoffman, Gregory R., Varadarajan, Malini, Ramadan, Nadire, Reece-Hoyes, John S., Wang, Qiong, Chen, Xin, McAllister, Gregory, Roma, Guglielmo, Bouwmeester, Tewis, Hoepfner, Dominic
Publicado 2017

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

por Bertschi, Nicole L, Voorberg-van der Wel, Annemarie, Zeeman, Anne-Marie, Schuierer, Sven, Nigsch, Florian, Carbone, Walter, Knehr, Judith, Gupta, Devendra K, Hofman, Sam O, van der Werff, Nicole, Nieuwenhuis, Ivonne, Klooster, Els, Faber, Bart W, Flannery, Erika L, Mikolajczak, Sebastian A, Chuenchob, Vorada, Shrestha, Binesh, Beibel, Martin, Bouwmeester, Tewis, Kangwanrangsan, Niwat, Sattabongkot, Jetsumon, Diagana, Thierry T, Kocken, Clemens HM, Roma, Guglielmo
Publicado 2018

IRF2 is a master regulator of human keratinocyte stem cell fate

por Mercado, Nicolas, Schutzius, Gabi, Kolter, Christian, Estoppey, David, Bergling, Sebastian, Roma, Guglielmo, Gubser Keller, Caroline, Nigsch, Florian, Salathe, Adrian, Terranova, Remi, Reece-Hoyes, John, Alford, John, Russ, Carsten, Knehr, Judith, Hoepfner, Dominic, Aebi, Alexandra, Ruffner, Heinz, Beck, Tanner C., Jagannathan, Sajjeev, Olson, Calla M., Sheppard, Hadley E., Elsarrag, Selma Z., Bouwmeester, Tewis, Frederiksen, Mathias, Lohmann, Felix, Lin, Charles Y., Kirkland, Susan
Publicado 2019