Assessment of the allergic potential of food protein extracts and proteins on oral application using the brown Norway rat model.

por Knippels, Léon M J, Penninks, André H
Publicado 2003

The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies

por Wiertsema, Selma P., van Bergenhenegouwen, Jeroen, Garssen, Johan, Knippels, Leon M. J.
Publicado 2021

Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy

por Zhao, Xiaoli, Thijssen, Suzan, Chen, Hongbing, Garssen, Johan, Knippels, Leon M. J., Hogenkamp, Astrid
Publicado 2021

In Vitro Evidence for Immune-Modulatory Properties of Non-Digestible Oligosaccharides: Direct Effect on Human Monocyte Derived Dendritic Cells

por Lehmann, Sarah, Hiller, Julia, van Bergenhenegouwen, Jeroen, Knippels, Leon M. J., Garssen, Johan, Traidl-Hoffmann, Claudia
Publicado 2015

The Consequences of Multiple Simultaneous C-Type Lectin–Ligand Interactions: DCIR Alters the Endo-Lysosomal Routing of DC-SIGN

por García-Vallejo, Juan J., Bloem, Karien, Knippels, Léon M. J., Garssen, Johan, van Vliet, Sandra J., van Kooyk, Yvette
Publicado 2015

Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway

por Zhao, Xiaoli, Gao, Jinyan, Hogenkamp, Astrid, Knippels, Leon M. J., Garssen, Johan, Bai, Jing, Yang, Anshu, Wu, Yong, Chen, Hongbing
Publicado 2021

Assessment of protein allergenicity on the basis of immune reactivity: animal models.

por Kimber, Ian, Dearman, Rebecca J, Penninks, Andre H, Knippels, Leon M J, Buchanan, Robert B, Hammerberg, Bruce, Jackson, Hilary A, Helm, Ricki M
Publicado 2003

Selenomethionine attenuates allergic effector responses in human primary mast cells

por Zhao, Xiaoli, Blokhuis, Bart. R. J., Redegeld, Frank. A., Chang, Iris, Dunham, Diane, Chen, Hongbing, Nadeau, Kari, Garssen, Johan, Knippels, Leon M. J., Hogenkamp, Astrid
Publicado 2022

Development of β-Lactoglobulin-Specific Chimeric Human IgEκ Monoclonal Antibodies for In Vitro Safety Assessment of Whey Hydrolysates

por Knipping, Karen, Simons, Peter J., Buelens-Sleumer, Laura S., Cox, Linda, den Hartog, Marcel, de Jong, Niels, Teshima, Reiko, Garssen, Johan, Boon, Louis, Knippels, Léon M. J.
Publicado 2014

Human Milk Blocks DC-SIGN–Pathogen Interaction via MUC1

por Koning, Nathalie, Kessen, Sabine F. M., Van Der Voorn, J. Patrick, Appelmelk, Ben J., Jeurink, Prescilla V., Knippels, Leon M. J., Garssen, Johan, Van Kooyk, Yvette
Publicado 2015

Dietary Intervention with β-Lactoglobulin-Derived Peptides and a Specific Mixture of Fructo-Oligosaccharides and Bifidobacterium breve M-16V Facilitates the Prevention of Whey-Indu...

por Kostadinova, Atanaska I., Pablos-Tanarro, Alba, Diks, Mara A. P., van Esch, Betty C. A. M., Garssen, Johan, Knippels, Léon M. J., Willemsen, Linette E. M.
Publicado 2017

Ligand Binding and Signaling of Dendritic Cell Immunoreceptor (DCIR) Is Modulated by the Glycosylation of the Carbohydrate Recognition Domain

por Bloem, Karien, Vuist, Ilona M., van der Plas, Arend-Jan, Knippels, Léon M. J., Garssen, Johan, García-Vallejo, Juan J., van Vliet, Sandra J., van Kooyk, Yvette
Publicado 2013

A Specific Mixture of Fructo-Oligosaccharides and Bifidobacterium breve M-16V Facilitates Partial Non-Responsiveness to Whey Protein in Mice Orally Exposed to β-Lactoglobulin-Deriv...

por Kostadinova, Atanaska I., Meulenbroek, Laura A. P. M., van Esch, Betty C. A. M., Hofman, Gerard A., Garssen, Johan, Willemsen, Linette E. M., Knippels, Léon M. J.
Publicado 2017

Combined Exposure of Activated Intestinal Epithelial Cells to Nondigestible Oligosaccharides and CpG-ODN Suppresses Th2-Associated CCL22 Release While Enhancing Galectin-9, TGFβ, a...

por Overbeek, Saskia A., Kostadinova, Atanaska I., Boks, Martine A., Hayen, Simone M., de Jager, Wilco, van't land, Belinda, Knippels, Leon M., Garssen, Johan, Willemsen, Linette E. M.
Publicado 2019

Limited Lactosylation of Beta-Lactoglobulin from Cow’s Milk Exerts Strong Influence on Antigenicity and Degranulation of Mast Cells

por Bosman, Gerlof P., Oliveira, Sergio, Simons, Peter J., Sastre Torano, Javier, Somsen, Govert W., Knippels, Leon M. J., Haselberg, Rob, Pieters, Roland J., Garssen, Johan, Knipping, Karen
Publicado 2021

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow’s milk- and peanut allergy models

por Vonk, Marlotte M., Wagenaar, Laura, Pieters, Raymond H. H., Knippels, Leon M. J., Willemsen, Linette E. M., Smit, Joost J., van Esch, Betty C. A. M., Garssen, Johan
Publicado 2017

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow’s Milk Allergy Model: A Potential Role for Foxp3+ Regulatory T Cells

por Vonk, Marlotte M., Diks, Mara A. P., Wagenaar, Laura, Smit, Joost J., Pieters, Raymond H. H., Garssen, Johan, van Esch, Betty C. A. M., Knippels, Léon M. J.
Publicado 2017

Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

por Wagenaar, Laura, Bol‐Schoenmakers, Marianne, Giustarini, Giulio, Vonk, Marlotte M., van Esch, Betty C.A.M., Knippels, Leon M.J., Garssen, Johan, Smit, Joost J., Pieters, Raymond H.H.
Publicado 2018

Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow's Milk Allergic Mice

por Vonk, Marlotte M., Blokhuis, Bart R. J., Diks, Mara A. P., Wagenaar, Laura, Smit, Joost J., Pieters, Raymond H. H., Garssen, Johan, Knippels, Léon M. J., van Esch, Betty C. A. M.
Publicado 2019

IL-10 Receptor or TGF-β Neutralization Abrogates the Protective Effect of a Specific Nondigestible Oligosaccharide Mixture in Cow-Milk-Allergic Mice

por Kerperien, JoAnn, Veening-Griffioen, Désirée, Wehkamp, Tjalling, van Esch, Betty C A M, Hofman, Gerard A, Cornelissen, Paquita, Boon, Louis, Jeurink, Prescilla V, Garssen, Johan, Knippels, Leon M J, Willemsen, Linette E M
Publicado 2018